2012 Fiscal Year Final Research Report
Mechanisms for crosstalk between kidney and heart on diabeticmicroangiopathy: roles of the kidney as an organ of Na homeostasis
| Project/Area Number |
22590914
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jichi Medical University |
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Principal Investigator |
MUTO Shigeaki 自治医科大学, 医学部, 教授 (40190855)
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| Co-Investigator(Kenkyū-buntansha) |
MASUDA Takahiro 自治医科大学, 医学部, 助教 (10424037)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 糖尿病 / 心臓微小血管障害 / 腎臓微小血管障害 / 組織アンジオテンシンII / 腎臓Na輸送 / 容量負荷 / 心腎連関 |
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| Research Abstract |
In Spontaneously Diabetic Torii rats developing diabeticnephropathy, 1) volume expansion/overload via the stimulatory effect of angiotensin IIoverproduced in proximal tubules on the tubules`Na reabsorption induced angiotensin IIupregulation only in left v
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Research Products
(4 results)
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[Journal Article] Heart angiotensin II-inducedcardiomyocyte hypertrophy suppressescoronary angiogenesis and progressesdiabetic cardiomyopathy2012
Author(s)
Masuda T, Muto S, Fujisawa G,Iwazu Y,Kimura M, Kobayashi T, Nonaka-SarukawaM, Sasaki N, Watanabe Y,Shinohara M,Murakami T,Shimada K,Kobayashi E,KusanoE
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Journal Title
Am. J. Physiol.Heart Circ. Physiol
Volume: 302
Pages: H1871-H1883
Peer Reviewed
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