2012 Fiscal Year Final Research Report
Investigation of klotho protein on protective role of peritoneal membrane
| Project/Area Number |
22590920
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
SASAKI Tamaki 川崎医科大学, 医学部, 教授 (30187124)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Minoru 川崎医科大学, 医学部, 講師 (70449891)
FUJIMOTO Sohachi 川崎医科大学, 医学部, 講師 (00319948)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 人工透析学 |
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| Research Abstract |
The one of obstacles to successful long-term PD is peritoneal fibrosis in peritoneal membrane after exposure to non-physiologic dialysis solutions. Studies have demonstrated that peritoneal mesothelial cells undergoepithelial-to-mesenchymal transition (EMT) after expose to injury. EMT is the important role of the initial peritoneal fibrosis. The induction of EMT is associated with activation of Wnt-dependent beta-catenin signaling and the secreted klotho protein can regulate Wnt signaling. Overexpression of Klotho protein protects the peritoneal membranethrough attenuation of Wnt-signaling.
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Research Products
(18 results)
