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2012 Fiscal Year Final Research Report

Association between axonal damage and molecular basis in demyelinating neuropathies: prognosis and response to treatment

Research Project

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Project/Area Number 22590928
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNagoya University

Principal Investigator

KAWAGASHIRA Yuichi  名古屋大学, 医学部附属病院, 医員 (40569779)

Co-Investigator(Kenkyū-buntansha) IIJIMA Masahiro  名古屋大学, 大学院・医学系研究科, COE特任助教 (40437041)
KOIKE Haruki  名古屋大学, 大学院・医学系研究科, 病院助教 (80378174)
SOBUE Gen  名古屋大学, 大学院・医学系研究科, 教授 (20148315)
Project Period (FY) 2010 – 2012
Keywords脱髄性ニューロパチー / 軸索障害 / Axon-myelin interaction / 治療反応性 / イオンチャネル
Research Abstract

The association between axon-myelin interaction and functional several molecules which are distributed from node of Ranvie to juxtaparanode is well recognized. In this study, we analyzed immunohistochemically the distribution and expression of those molecules, including sodium channel, TAG-1, CNTN1, Caspr and Caspr2, using by teased-fiber preparation in patients with demyelinating neuropathies. The expression of sodium channel in demyelinating neuropathies showed markedly decrease compared with normal control although no morphological changes are observed in light microscopic study. In addition, we confirmed that homologous TAG-1 knockout mice resulted in significant ateliosis. These results may suggest that several molecules which is associated with axon-myelin interaction, including TAG-1, express their function in the development phase and play an important role in repair after demyelination.

  • Research Products

    (25 results)

All 2013 2012 2011 2010

All Journal Article (17 results) (of which Peer Reviewed: 16 results) Presentation (8 results)

  • [Journal Article] 各種疾患 末梢神経障害 抗MAG抗体陽性IgM-MGUSニューロパチーのリツキシマブによる新規治療の可能性2013

    • Author(s)
      川頭 祐一(名古屋大学 大学院・医学系研究科神経内科), 飯島 正博, 小池 春樹, 祖父江元
    • Journal Title

      Annual Review神経

      Volume: 2013巻 Pages: 223-229

  • [Journal Article] Impact of aging on the progression of neuropathy after liver transplantation in transthyretin Val30Met amyloidosis.2012

    • Author(s)
      Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Nakamura T, Watanabe H, Kamei H, Kiuchi T, Sobue G
    • Journal Title

      Muscle Nerve

      Volume: 46 Pages: 964-70

    • Peer Reviewed
  • [Journal Article] Differential, size-dependent sensory neuron involvement in the painful and ataxic forms of primary Sogren's syndrome-associated neuropathy.2012

    • Author(s)
      Kawagashira Y, Koike H, Fujioka Y, Hashimoto R, Tomita M, Morozumi S, Iijima M, Katsuno M, Tanaka F, Sobue G
    • Journal Title

      J Neurol Sci.

      Volume: 319 Pages: 319

    • Peer Reviewed
  • [Journal Article] The significance of folate deficiency in alcoholic and nutritional neuropathies: analysis of a case.2012

    • Author(s)
      Koike H, Hama T, Kawagashira Y, Hashimoto R, Tomita M, Iijima M, Sobue G
    • Volume
      28
    • Pages
      821-4
    • Peer Reviewed
  • [Journal Article] The spectrum of clinicopathological features in pure autonomic neuropathy.2012

    • Author(s)
      Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Koyano S, Momoo T, Yuasa H, Mitake S, Higashihara M, Kaida K, Yamamoto D, Hisahara S, Shimohama S, Nakae Y, Johkura K, Vernino S, Sobue G
    • Journal Title

      J Neurol

      Volume: 259 Pages: 2067-75

    • Peer Reviewed
  • [Journal Article] Natural history of transthyretin Val30Met familial amyloid polyneuropathy: analysis of late-onset cases from non-endemic areas2012

    • Author(s)
      Koike H, Tanaka F, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Fujitake J, Kawanami T, Kato T, Yamamoto M, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83(2) Pages: 152-8

    • Peer Reviewed
  • [Journal Article] Crow-Fukase症候群における髄鞘の形態変化の特徴2012

    • Author(s)
      橋本 里奈(名古屋大学 神経内科), 小池 春樹, 冨田 稔, 川頭 祐一, 飯島 正博, 祖父江元
    • Journal Title

      末梢神経(0917-6772)

      Volume: 23巻1号 Pages: 95-101

    • Peer Reviewed
  • [Journal Article] The wide range of clinical manifestations in leprous neuropathy: two case reports2011

    • Author(s)
      Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Nagamatsu M, Sobue G
    • Journal Title

      Intern Med

      Volume: 50(19) Pages: 2223-6

    • Peer Reviewed
  • [Journal Article] Spatial distribution of nerve fiber pathology and vasculitis in microscopic polyangiitis-associated neuropathy.2011

    • Author(s)
      Morozumi S, Koike H, Tomita M, Kawagashira Y, Iijima M, Katsuno M, Hattori N, Tanaka F, Sobue G
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 70(5) Pages: 340-8

    • Peer Reviewed
  • [Journal Article] Diagnosis of sporadic transthyretin Val30Met familial amyloid polyneuropathy: a practical analysis2011

    • Author(s)
      Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Tanaka F, Sobue G
    • Journal Title

      Amyloid

      Volume: 18(2) Pages: 53-62

    • Peer Reviewed
  • [Journal Article] Central nervous system involvement in n-hexane polyneuropathy demonstrated by MRI and proton MR spectroscopy2011

    • Author(s)
      Hashizume A, Koike H, Kawagashira Y, Banno H, Suzuki K, Ito M, Katsuno M, Watanabe H, Tanaka F, Naganawa S, Kaneko R, Ishii A, Sobue G
    • Journal Title

      Clin Neurol Neurosurg

      Volume: 113(6) Pages: 493-5

    • Peer Reviewed
  • [Journal Article] Systemic but asymptomatic transthyretin amyloidosis 8 years after domino liver transplantation2011

    • Author(s)
      Koike H, Kiuchi T, Iijima M, Ueda M, Ando Y, Morozumi S, Tomita M, Kawagashira Y, Watanabe H, Katsuno M, Shimoyama Y, Okazaki Y, Kamei H, Sobue G.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 82(11) Pages: 1287-90

    • Peer Reviewed
  • [Journal Article] Morphological progression of myelin abnormalities in IgM-monoclonal gammopathy of undetermined significance anti-myelin-associated glycoprotein neuropathy2010

    • Author(s)
      Kawagashira Y, Koike H, Tomita M, Morozumi S, Iijima M, Nakamura T, Katsuno M, Tanaka F, Sobue G
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 69(11) Pages: 1143-57

    • Peer Reviewed
  • [Journal Article] IgM MGUS anti-MAG neuropathy with predominant muscle weakness and extensive muscle atrophy2010

    • Author(s)
      Kawagashira Y, Kondo N, Atsuta N, Iijima M, Koike H, Katsuno M, Tanaka F, Kusunoki S, Sobue G
    • Journal Title

      Muscle Nerve

      Volume: 42(3) Pages: 433-5

    • Peer Reviewed
  • [Journal Article] Differential response to intravenous immunoglobulin (IVIg) therapy among multifocal and polyneuropathy types of painful diabetic neuropathy2010

    • Author(s)
      Kawagashira Y, Watanabe H, Morozumi S, Iijima M, Koike H, Hattori N, Sobue G
    • Journal Title

      J Clin Neurosci

      Volume: 17(8) Pages: 1003-8

    • Peer Reviewed
  • [Journal Article] Slowly progressive autonomic neuropathy with antiganglionic acetylcholine receptor antibody2010

    • Author(s)
      Koike H, Koyano S, Morozumi S, Kawagashira Y, Iijima M, Katsuno M, Hattori N, Vernino S, Sobue G
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 81(5) Pages: 586-7

    • Peer Reviewed
  • [Journal Article] Pyramidal tract involvement in Guillain-Barre syndrome associated with anti-GM1 antibody2010

    • Author(s)
      Tomita M, Watanabe H, Morozumi S, Kawagashira Y, Iijima M, Nakamura T, Katsuno M, Koike H, Hattori N, Hirayama M, Kusunoki S, Sobue G
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 81(5) Pages: 583-5

    • Peer Reviewed
  • [Presentation] 抗Myelin-associated-glycoprotein抗体陽性IgM-MGUSニューロパチーにおけるRituximab療法の有用性2012

    • Author(s)
      川頭祐一(名古屋大学 神経内科),大山健,橋本里奈,冨田稔,飯島正博,小池春樹,祖父江元
    • Organizer
      日本神経免疫学会
    • Place of Presentation
      軽井沢
    • Year and Date
      20120920-21
  • [Presentation] 高度の神経肥厚を特徴とする慢性炎症性脱髄性多発根ニューロパチーの臨床病理学的検討2012

    • Author(s)
      飯島 正博(名古屋大学 神経内科), 両角佐織, 小池 春樹, 川頭 祐一, 冨田 稔,橋本 里奈, 大山 健, 祖父江 元
    • Organizer
      日本神経免疫学会
    • Place of Presentation
      軽井沢
    • Year and Date
      20120920-21
  • [Presentation] 抗Myelin-Associated Glycoprotein (MAG)抗体陽性IgM-MGUSニューロパチーにおける重症度と治療効果に影響する因子2012

    • Author(s)
      川頭祐一(名古屋大学 神経内科),橋本里奈,冨田稔,飯島正博,小池春樹,祖父江元
    • Organizer
      日本末梢神経学会
    • Place of Presentation
      福岡
    • Year and Date
      20120831-0901
  • [Presentation] 高度の神経肥厚を特徴とする慢性炎症性脱髄性多発根ニューロパチーの検討2012

    • Author(s)
      飯島 正博(名古屋大学 神経内科), 両角佐織, 小池 春樹, 川頭 祐一, 冨田 稔, 橋本 里奈, 大山 健, 祖父江 元
    • Organizer
      日本末梢神経学会
    • Place of Presentation
      福岡
    • Year and Date
      20120831-0901
  • [Presentation] Characteristics of hypertrophic form in chronic inflammatory demyelinating polyneuropathy. Inflammatory Neuropathy consortium2012

    • Author(s)
      Masahiro Iijima, Ken Ohyama, Rina Hashimoto, Minoru Tomita, Yuichi Kawagashira, Haruki Koike, Gen Sobue
    • Organizer
      Inflammatory Neuropathy Consortium
    • Place of Presentation
      Rotterdam, Netherland.
    • Year and Date
      20120624-27
  • [Presentation] Gene expression analysis of biopsied nerve in Japanese CIDP patients2011

    • Author(s)
      Masahiro Iijima, Haruki Koike, Yuichi Kawagashira, Minoru Tomita, Rina Hashimoto, Gen Sobue
    • Organizer
      Peripheral Nerve Society
    • Place of Presentation
      Washington DC., U.S.A
    • Year and Date
      20110625-29
  • [Presentation] Rituximab療法を施行した抗Myelin-Associated-Glycoprotein (MAG)抗体陽性IgM-MGUSニューロパチーの4例2010

    • Author(s)
      川頭祐一(名古屋大学 神経内科),橋本里奈,冨田稔,飯島正博,小池春樹,祖父江元
    • Organizer
      日本末梢神経学会
    • Place of Presentation
      仙台
    • Year and Date
      20100903-04
  • [Presentation] シェーグレン症候群に伴うニューロパチー: Ataxic form とPainful formの病理学的特徴2010

    • Author(s)
      川頭祐一(名古屋大学 神経内科),藤岡祐介,冨田稔,両角佐織,飯島正博,小池春樹,祖父江元
    • Organizer
      日本神経免疫学会
    • Place of Presentation
      東京
    • Year and Date
      20100317-19

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Published: 2014-08-29  

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