2012 Fiscal Year Final Research Report
Research on the role of Omi/HtrA2 in the abnormal mitochondria in patients with Parkinson's disease
| Project/Area Number |
22590930
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Hidefumi 京都大学, 医学研究科, 講師 (20250061)
TAKAHASHI Ryosuke 京都大学, 医学研究科, 教授 (90216771)
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| Project Period (FY) |
2010 – 2012
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| Keywords | Omi/HtrA2 / パーキンソン病 / ミトコンドリア / アポトーシス / XIAP |
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| Research Abstract |
We confirmed that Lewy bodies were immunoreactive for XIAP, which is negatively regulated by Omi/HtrA2, and that XIAP and Omi/HtrA2 immunoreactivity were co-localized to Lewy bodies. Our research focused on apoptosome-related proteins demonstrated the immunohistochemical localization of cytochrome c, Apaf-1 and caspase-9 in Lewy bodies. We also found that cleaved caspase-9 immunoreactivity was localized to Lewy bodies, suggesting that caspase-9 may be activated in brains from patients with Parkinson’s disease.
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[Journal Article] An autopsy case of SOD1-related ALS with TDP-43 positive inclusions2011
Author(s)
Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto Y, Takahashi R, Ito H
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Journal Title
Neurology
Volume: 77:1993-1995
DOI
Peer Reviewed
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[Journal Article] Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model2011
Author(s)
Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R
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Journal Title
PLoS One
Volume: 6:e20427
DOI
Peer Reviewed
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