2012 Fiscal Year Final Research Report
11C-Acetate PET imaging for the evaluation of astrocytes in Multiple Sclerosis
| Project/Area Number |
22590931
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKATA Kazushiro 大阪大学, 医学部付属病院, 医員 (20573223)
KINOSHITA Makoto 大阪大学, 医学部付属病院, 医員 (10573222)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アストロサイト / 酢酸 / PET / 多発性硬化症 / NMO |
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| Research Abstract |
Astroglial activation in patients with multiple sclerosis (MS) and NMO was evaluated by PET using 11C-acetate as an astrocyte specific radio-ligand. Standardized uptake value (SUV) was significantly increased in the brain of patients with MS compared to healthy volunteer (HV). The SUV of NMO patients was similar to that of HV. These results suggest that 11C-acetate PET can be a useful examination for the evaluation of astrocyte metabolism and for the diagnosis of MS/NMO.
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[Presentation] Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells.2010
Author(s)
Kinoshita M, Nakatsuji Y, Kimura T, Moriya M, Takata K, Okuno T, Kumanogoh A, Kajiyama K, Yoshikawa H, Sakoda S
Organizer
The 10th International Congress of Neuroimmunology
Place of Presentation
Barcelona, Spain.
Year and Date
20101000
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[Presentation] Sema4A is a serum diagnostic marker of Multiple Sclerosis, which reflects the Th17 shift of PBMC.2010
Author(s)
Nakatsuji Y, Okuno T, Moriya M, SugimotoT, Kinoshita M, Nakano M, Kikutani H, Sakoda S, Kumanogoh A.
Organizer
The 10th International Congress of Neuroimmunology
Place of Presentation
Barcelona, Spain
Year and Date
20101000
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