2012 Fiscal Year Final Research Report
Functional roles of brain pericytes during brain ischemia
| Project/Area Number |
22590937
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
AGO Tetsuro 九州大学, 大学病院, 助教 (30514202)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳血管 / 神経再生 / 脳梗塞 / ペリサイト / Caシグナル |
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| Research Abstract |
Extracellular acidification caused Ca oscillation via activation of NHE1 in reverse mode and subsequently phosphorylated CaMKII. Phosphorylated CaMKII translocated into nuclei and phosphorylated CREB, leading to initiation of gene transcription. In rat or mouse middle cerebral artery occlusion model, brain pericytes migrated into peri-infarct areas. They expressed CREB and secreted a variety of nerve growth factors, indicating that pericytes may play a neuroprotective role during brain ischemia.
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