2012 Fiscal Year Final Research Report
Impairment of excitation-contraction-coupling in myasthenia gravis
| Project/Area Number |
22590960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
IMAI Tomihiro 札幌医科大学, 医学部, 講師 (40231162)
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| Co-Investigator(Kenkyū-buntansha) |
HOZUKI Takayoshi 札幌医科大学, 医学部, 研究員 (80464501)
TSUDA Emiko 札幌医科大学, 医学部, 研究員 (90464495)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床神経生理学 |
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| Research Abstract |
The results of this study were:
The results of this study were: 1) to develop measurement of excitation-contraction coupling time (ECCT) of masseter using an accelerometer;
2) to elucidate the relationship between the impairment of E-C coupling of masseter and the bite force in patients with myasthenia gravis (MG).
Masseteric E-C coupling is impaired in some MG patients, and functional recovery of E-C coupling contributes to the increase in biteforce at least in part after treatment.
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