Roles of KATP channel/insulin signaling in the hypothalamus on the regulation of glucose homeostasis

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590970
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Chiba University
• Principal Investigator: MIKI Takashi 千葉大学, 大学院・医学研究院, 教授 (50302568)
• Project Period (FY): 2010 – 2012
• Keywords: エネルギー / 糖質代謝異常

Research Abstract

KATP channel is suggested to regulate cellular excitability of various cell types by acting as a metabolic sensor. Especially, the channel in the hypothalamus, the metabolic center in the body, plays an important role in metabolic regulation of insulin targeted tissues. In the present study, we found that insulin signaling in the adipose tissues is modulated exogenously by the brain KATP channel and that KATP channel is involved in the glucose sensing in several nuclei in the brain stem as well as the hypothalamus.

Research Products

• [Journal Article] A case of Type 1 diabetes with nocturnal hypoglycemia after desensitization therapy for insulin allergy (2013)
  • Author(s): Kitamoto, T., Sakurai, K., Tachibana K., Yokoh H., Ishikawa, K., Miki, T., Yokote K
  • Journal Title: Diabetes Care Volume: (in press)
  • Peer Reviewed
• [Journal Article] Refeeding with a standard diet after a 48-h fast elicits an inflammatory response in the mouse liver (2013)
  • Author(s): Oarada M, Miki T, Kohno S, Sakai K, Nikawa T, Yoneyama M, Gonoi T.
  • Journal Title: J Nutr Biochem Volume: (in press)
  • DOI: DOI:10.1016/j.jnutbio.2012.10.006
  • Peer Reviewed
• [Journal Article] A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells (2012)
  • Author(s): Ogata, S., Miki, T., Seino, S., Tamai, S., Kasai, H., Nemoto, T.
  • Journal Title: PLoS ONE12 Volume: 7(5) Pages: e37048
  • DOI: DOI:10.1371/journal.pone.0037048
  • Peer Reviewed
• [Journal Article] Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar versus non-nutritive sweetener (2012)
  • Author(s): Sakurai, K., Lee, EY., Morita, A., Kimura, S., Kawamura, H., Kasamatsu, A.,Shiiba, M., Yabe, D., Yokote,K., Miki, T
  • Journal Title: J Diabetes Invest Volume: 3 Pages: 156-63
  • DOI: DOI:10.1111/j.2040-1124.2011.00163.x
  • Peer Reviewed
• [Journal Article] Beneficial effects of ventromedial hypothalamus (VMH) lesioning on functionand morphology of the liver after hepatectomy in rats (2011)
  • Author(s): Lee, EY., Inoue, S., Senoo, A., Shimizu, H., Suzuki Y., Ishizuka, N., Imazeki, N., Sasaki, K., Kako, M., Osaka, T., Miki, T.
  • Journal Title: Brain Res Volume: 1421 Pages: 82-9
  • DOI: Doi:10.1016/j.brainres.2011.09.012
  • Peer Reviewed
• [Journal Article] Pancreatic β-cells are generated by neogenesis from non-β-cells after birth (2011)
  • Author(s): Nakamura, K., Minami, K., Tamura, K., Iemoto, K., Miki,T., Seino, S.
  • Journal Title: Biomed Res Volume: 3 Pages: 167-74
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21551953
  • Peer Reviewed
• [Journal Article] Inhibition of ATP-Sensitive K(+) Channels and L-Type Ca(2+) Channels by Amiodarone Elicits Contradictory Effect on Insulin Secretion in MIN6 Cells (2011)
  • Author(s): Nishida, A., Takizawa, T., Matsumoto, A., Miki,T., Seino, S., Nakaya, H.
  • Journal Title: J Pharmacol Sci Volume: 116(1) Pages: 73-80
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21512308
  • Peer Reviewed
• [Journal Article] Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenophysis of mice (2011)
  • Author(s): Iwanaga, T., Miki,T., Takahashi- Iwanaga, H.
  • Journal Title: Biomed Res Volume: 32 Pages: 73-81
  • DOI: DOI:10.2220/biomedres.32.73
  • Peer Reviewed
• [Journal Article] Establishment of new clonal pancreatic β-cell lines (MIN6-K) useful for study of incretin/cAMP signaling (2010)
  • Author(s): Iwasaki, M., Minami K., Shibasaki, T., Miki,T., Jun-ichi Miyazaki, J-I., Seino, S.
  • Journal Title: J Diabetes Invest Volume: 4 Pages: 137-142
  • DOI: DOI:10.1111/j.2040-1124.2010.00026.x
  • Peer Reviewed
• [Journal Article] Rim2α determines docking and priming states in insulin granule exocytosis (2010)
  • Author(s): Yasuda, T., Shibasaki, T., Minami, K., Takahashi, H., Mizoguchi, A., Uriu, Y., Mori, Y., Miyazaki, J-I, Miki,T., Seino, S.
  • Journal Title: Cell Metab Volume: 12(2) Pages: 117-129
  • DOI: DOI:10.1016/j.cmet.2010.05.017
  • Peer Reviewed
• [Presentation] 腸管内分泌L細胞 からの糖によるGLP-1 (2013)
  • Author(s): Takashi Miki
  • Organizer: 分泌メカニズム第90回日本生理学会
  • Place of Presentation: 東京
  • Year and Date: 20130327-29
• [Presentation] Enhanced VEGF signaling in islets contributes to β-cell injury and consequential diabetes in SDT rats (2012)
  • Author(s): Mukai, E., Ohta, T., Kawamura, H., Lee, E.Y., Morita, A., Inagaki, N., Iwanaga, T., Miki, T.
  • Organizer: 9th IDF-WPR Congress & 4th AASD Scientific Meeting
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20121124-27
• [Presentation] Increased gluconeogenesis from glycerol plays a critical role in developing diabetes under high fat diet (2012)
  • Author(s): Lee, EY., Sakurai, K., Toda,C., Yokote, K., Minokoshi, Y, Miki, T.
  • Organizer: the 9th IDF-WPR Congress & 4th AASD Scientific Meeting
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20121024-27
• [Presentation] Effect of an alpha-glucosidase inhibitor acarbose on glucagon-like peptide-1 secretion and postprandial lipid profile (2011)
  • Author(s): Sakurai, K., Lee, EY, Morita, A., Yabe, D., Yokote, K., Miki, T.
  • Organizer: AASD2011 3rd Annual Meeting
  • Place of Presentation: Beijing, China
  • Year and Date: 20110722-24
• [Presentation] Cellular mechanism for GLP-1 specific insulinotropic action in pancreatic β-cells (2010)
  • Author(s): Takashi Miki, Susumu Seino
  • Organizer: 第53回日本糖尿病学会年次学術集 会.(糖尿病 53, S37, 2010)
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-28
• [Book] GLP-1分泌に関する最新の知 (2013)
  • Author(s): 三木隆司
  • Total Pages: 95-99,222
  • Publisher: Progress in Medicine 33
• [Book] 各栄養素による膵β細胞におけるインスリン分泌と代謝制御 (2012)
  • Author(s): 三木隆司
  • Total Pages: 290-297,384
  • Publisher: 内分泌糖尿病代謝内科
• [Book] 京都廣川書店 (2011)
  • Author(s): 三木隆司
  • Total Pages: 86-95,471
  • Publisher: 細胞内外のATPセンサーであるATP感受性K+チャネルとATP受容体.トランスポートソームの世界-膜輸送研究の源流から未来へ-
• [Book] 肝臓の輸送機能と代謝機能.ギャノング生理学原書23版,岡田泰伸監訳 (2011)
  • Author(s): 三木隆司
  • Total Pages: 562-572,838
  • Publisher: 丸善
• [Book] 転写因子Dmbx1欠損マウスのやせの病態解析 (2011)
  • Author(s): 李恩瑛,三木隆司
  • Total Pages: 225-231,288
  • Publisher: Adipo science 7
• [Book] GLP-1の血糖降下作用のメカニズムは? (2010)
  • Author(s): 三木隆司
  • Total Pages: 530-532,144
  • Publisher: 肥満と糖尿病9
• [Remarks]
  • URL: http://www.m.chiba-u.ac.jp/class/physiol/index.html