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2012 Fiscal Year Final Research Report

Metabolic regulation by adipose tissue macrophage and interleulin-10

Research Project

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Project/Area Number 22590971
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionUniversity of Toyama

Principal Investigator

USUI Isao  富山大学, 大学病院, 講師 (50377272)

Co-Investigator(Kenkyū-buntansha) TOBE Kazuyuki  富山大学, 大学院・医学薬学研究部(医学), 教授 (30251242)
Co-Investigator(Renkei-kenkyūsha) MINOKOSHI Yasuhiko  生理学研究所, 発達生理学研究系, 教授 (10200099)
Project Period (FY) 2010 – 2012
Keywords内科系臨床医学 / 代謝学
Research Abstract

In this study, we investigated the relationship between adipose tissue M1/M2 macrophages and insulin sensitivity, focusing on the roles of M2 macrophage and interleukin10 (IL-10). Telmisartan, an angiotensin II type I receptor blocker, induced M2 polarity of adipose tissue macrophages with its PPARγ-stimulating activity, while adipose tissue hypoxia induced the M1 polarity. M2 macrophage ablation mice, in which the number of M2 macrophage could be decreased by adding diphtheria toxin, showed smaller adipocyte size and improved insulin sensitivity. The activation of IL-10 signaling in hypothalamus increased the expression of mitochondria-related genes in skeletal muscle and improved inulin sensitivity.

  • Research Products

    (20 results)

All 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results) Book (6 results)

  • [Journal Article] Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.2013

    • Author(s)
      Fujisaka S, Usui I, Ikutani M, Aminuddin A, Takikawa A, Tsuneyama K, Mahmood A, Goda N, Nagai Y, Takatsu K, Tobe K.
    • Journal Title

      Diabetologia

      Volume: 56(6) Pages: 1403-12

    • Peer Reviewed
  • [Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation2012

    • Author(s)
      Watanabe Y., Nakamura T., Ishikawa S., Fujisaka S., Usui I., Tsuneyama K., Ichihara Y., Wada T., Hirata Y., Suganami T., Izaki H., Akira S., Miyake K., Kanayama H., Shimabukuro M., Sata M., Sasaoka T.,Ogawa Y., Tobe K., Takatsu K., and Nagai Y.
    • Journal Title

      Diabetes.

      Volume: 61(5) Pages: 1199-209

    • Peer Reviewed
  • [Journal Article] Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice2011

    • Author(s)
      Fujisaka S., Usui I., Kanatani Y., Ikutani M., Takasaki I., Tsuneyama K., Tabuchi Y., Bukhari A., Yamazaki Y., Suzuki H., Senda S., Aminuddin A., Nagai Y., Takatsu K., Kobayashi M., To be K.
    • Journal Title

      Endocrinology

      Volume: 152(5) Pages: 1789-99

    • Peer Reviewed
  • [Journal Article] Deletion of platelet-derived growth factor receptor-βimproves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase II α (Thr286 Asp) transgenic mice2011

    • Author(s)
      Suzuki H., Usui I., Kato I., Oya T., Kanatani Y., Yamazaki Y., Fujisaka S., Senda S., Ishii Y., Urakaze M., Mahmood A., Takasawa S., Okamoto H., Kobayashi M., To be K., Sasahara M
    • Journal Title

      Diabetologia

      Volume: 54 Pages: 2953-2962

    • Peer Reviewed
  • [Presentation] Depletion of CD206-positive cells is associated with increased WAT proliferation and improved insulin sensitivity2013

    • Author(s)
      Aminuddin A., Fujisaka S., Mori H., Kohno K., Usui I., To be K..
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-17
  • [Presentation] 脂肪組織低酸素とインスリン抵抗性2013

    • Author(s)
      薄井勲、藤坂志帆、瀧川章子、Arshad Mahmood、戸邉一之
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Year and Date
      2013-05-17
  • [Presentation] Impact of Adipose Tissue Hypoxia on Macriphage Polarization in Diet-induced Obese Mice.2012

    • Author(s)
      Fujisaka S., Usui I., Ikutani M., Aminuddin A., Senda S., Takikawa A., Ishiki M., Koshimizu Y., Tsuneyama K., Nagai Y., Takatsu K., To be K.
    • Organizer
      American Diabetes Association 72nd Scientific Sessions
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2012-06-09
  • [Presentation] Myeloid Cell-specific Deletion of SIRT1 Impairs Glucose Metabolism wiht Enhanced Inflammatory Response to Hypoxia2012

    • Author(s)
      Takikawa A., Usui I., Senda S., Fujisaka S., Hattori S., Tsuneyama K., Aminuddin A., Mahmood A., Sasaoka T., Mori H., To be K.
    • Organizer
      American Diabetes Association 72nd Scientific Sessions
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2012-06-09
  • [Presentation] 慢性炎症とインスリン抵抗性 脂肪組織マクロファージとSIRT1(シンポジウム)2012

    • Author(s)
      薄井勲,藤坂志帆,瀧川章子,金谷由紀子,戸邉一之
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-17
  • [Presentation] 肥満脂肪組織の低酸素がマクロファージの極性に与える影響。(シンポジウム)2011

    • Author(s)
      薄井勲、戸邉一之
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      兵庫
    • Year and Date
      2011-09-23
  • [Presentation] Hyperleptinemia induces leptin resistancce and further worsening obesity2011

    • Author(s)
      Senda S., Inoue A., Suzuki R., Kamei N., Watanabe T., Mahmood A., Takikawa A., Aminuddin A., Fujisaka S., Koshimizu Y., Ishiki M., Usui I., Kadowaki T., To be K.
    • Organizer
      American Diabetes Association's 71st Scientific Sessions
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-06-26
  • [Presentation] Obesity-induced hypoxia regulates the polarization of adipose tissue macrophages.2011

    • Author(s)
      FujisakaS., UsuiI., Ikutani M., Kanatani Y., Senda S., TakikawaA., Aminuddin, SuzukiH., IshikiM., IwataM., NagaiY., TakatsuK., To be K
    • Organizer
      American Diabetes Association's 71st Scientific Sessions
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-06-26
  • [Presentation] インスリン抵抗性のメカニズムと新しい治療戦略脂肪組織マクロファージとインスリン抵抗性。(シンポジウム)2011

    • Author(s)
      薄井勲、藤坂志帆、瀧川章子、仙田聡子、小清水由紀子、戸邉一之
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
  • [Presentation] 低酸素環境に対するM1/M2マクロファージの反応性に関する検討2011

    • Author(s)
      藤坂志帆,薄井勲,生谷尚士,仙田聡子,瀧川章子,AminuddinAminuddin,金谷由紀子,長井良憲,石木学,戸邉一之
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-21
  • [Book] 最新臨床糖尿病学 上-糖尿病学の最新動向-】糖尿病研究の進歩 インスリン作用およびインスリン抵抗性発現機序 インスリン抵抗性発現の分子機構 インスリン抵抗性における炎症の役割.日本臨床2012

    • Author(s)
      薄井勲、戸邉一之
    • Total Pages
      70: 191-195
    • Publisher
      日本臨床社
  • [Book] 【自然免疫Update-研究最前線】自然免疫の関わる病態と治療への応用 M2マクロファージと疾患.医学のあゆみ2012

    • Author(s)
      薄井勲、戸邉一之
    • Total Pages
      243: 129-134
    • Publisher
      医歯薬出版
  • [Book] 脂肪組織におけるマクロファージとインスリン抵抗性.Diabetes Journal2011

    • Author(s)
      薄井勲、藤坂志帆,戸邉一之
    • Total Pages
      39(2):50-55
    • Publisher
      協和企画
  • [Book] インスリン作用発現とその制御機構.日本臨床2011

    • Author(s)
      薄井勲、戸邉一之
    • Total Pages
      69:138-144
    • Publisher
      日本臨床社
  • [Book] 2型糖尿病のインスリン抵抗性における炎症の役割.日本臨床2011

    • Author(s)
      薄井勲、戸邉一之
    • Total Pages
      69:555-562
    • Publisher
      日本臨床社
  • [Book] 脂肪組織でのインスリン作用とインスリン抵抗性.ホルモンと臨床2011

    • Author(s)
      薄井勲、戸邉一之
    • Total Pages
      389-393
    • Publisher
      医学の世界社

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Published: 2014-08-29  

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