2013 Fiscal Year Final Research Report
The Role of Crosstalk between ChREBP and Clock-related genes in the Development of Metabolic syndrome
| Project/Area Number |
22590973
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Gifu University |
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Principal Investigator |
IIZUKA Katsumi 岐阜大学, 医学部附属病院, 講師 (40431712)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Jun 岐阜大学, 大学院医学系研究科, 教授 (40270855)
HORIKAWA Yukio 岐阜大学, 医学部附属病院, 准教授 (10323370)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | メタボリックシンドローム / ChREBP / 概日リズム / 時計遺伝子 / KLF-10 / グルカゴン受容体 / PPARα / LRH-1 |
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| Research Abstract |
We studied the role of crosstalk between carbohydrate-responsive element-binding protein (ChREBP) and clock-related genes (Klf-10 and Ppara) in the development of metabolic syndrome. Use of the feedback loop between ChREBP and clock-related genes is a common method for regulating both metabolic pathways and the circadian rhythm. Considering disorders in both metabolism and circadian rhythm coexist in metabolic syndrome, suppression of ChREBP transactivities will be beneficial in preventing metabolic syndrome.
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