2012 Fiscal Year Final Research Report
Role of GIP receptor signal in adipose tissue
| Project/Area Number |
22590975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kyoto University |
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Principal Investigator |
HARADA Norio 京都大学, 大学院・医学研究科 糖尿病・栄養内科学, 助教 (50530169)
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| Project Period (FY) |
2010 – 2012
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| Keywords | GIP / インクレチン / 肥満 |
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| Research Abstract |
In this study, we clarified the effect of GIP on adipose tissue in vivo using adipose tissue specific GIP receptor-deficient mice (GIPR^<adipo-/->). We fed high-hat diet (HFD) to aP2-Cre transgenic mice (aP2-Cre), floxed GIP receptor (lox-GIPR), and GIPR^<adipo-/->for 8 weeks. Body weight changes were significantly lower in GIPR^<adipo-/->than those in aP2-Cre and lox-GIPR. Oral glucose tolerance test showed that insulin levels were significantly lower in GIPR^<adipo-/->than those in aP2-Cre and lox-GIPR, although blood glucose levels did not differ among three types of mice. Insulin tolerance test showed that insulin resistance was improved in GIPR^<adipo-/->. Liver mass and fat content in liver were decreasedin GIPR^<adipo-/->than those in aP2-Cre and lox-GIPR. These results suggested that inhibition of GIP receptor signal in adipose tissue might decrease fat content in liver and improve insulin resistance under HFD-fed condition.
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Research Products
(42 results)
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[Journal Article] Enteral supplement enriched with glutamine, fiber, and oligosaccharide attenuates experimental colitis in mice2013
Author(s)
Joo E, Yamane S, Hamasaki A, Harada N, Matsunaga T, Muraoka A, Suzuki K, Nasteska D, Fukushima T, Hayashi T, Tsuji H, Shide K, Tsuda K, Inagaki N
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Journal Title
Nutrition
Volume: 29(3):549-55
DOI
Peer Reviewed
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[Journal Article] Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity2013
Author(s)
Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, Joo E, Shibue K, Harada T, Hamasaki A, Toyoda K, Nagashima K, Inagaki N
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Journal Title
J Biol Chem
Volume: 288(3):1929-38
DOI
Peer Reviewed
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[Journal Article] Self-monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)-treated type 2 diabetes (SMBG-OHA study)2013
Author(s)
Harashima S, Fukushima T, Sasaki M, Nishi Y, Fujimoto S, Ogura M, Yamane S, Tanaka D, Harada N, Hamasaki A, Nagashima K, Nakahigashi Y, Seino Y, Inagaki N
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Journal Title
Diabetes Metab Res Rev
Volume: 29(1):77-84
DOI
Peer Reviewed
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[Journal Article] Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion2012
Author(s)
Sakamoto E, Seino Y, Fukami N, Tsunekawa S, Ishikawa K, Ogata H, Uenishi E, Kamiya H, Hamada Y, Sato H, Harada N, Toyoda Y, Miwa I, Nakamura J, Inagaki N, Oiso Y, Ozaki N
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Journal Title
J Diabetes Invest
Volume: 3(5):432-440
DOI
Peer Reviewed
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[Journal Article] Beneficial Effects of Exendin-4 on Experimental Polyneuropathy in Diabetic Mice2012
Author(s)
Himeno T, Kamiya H, Naruse K, Harada N, Ozaki N, Seino Y, Shibata T, Kondo M, Kato J, Okawa T, Fukami A, Hamada Y, Inagaki N, Seino Y, Drucker DJ, Oiso Y, Nakamura J
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Journal Title
Diabetes
Volume: 60(9): 2397-2406
DOI
Peer Reviewed
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[Journal Article] The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice2012
Author(s)
Ogawa E, Hosokawa M, Harada N, Yamane S, Hamasaki A, Toyoda K, Fujimoto S, Fujita Y, Fukuda K, Tsukiyama K, Yamada Y, Seino Y, Inagaki N
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Journal Title
Biochem Biophys Res Commun
Volume: 404(1):115-20
DOI
Peer Reviewed
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[Journal Article] Exendin-4 Protects Pancreatic Beta Cells from the Cytotoxic Effect of Rapamycin by Inhibiting JNK and p38 Phosphorylation2010
Author(s)
Kawasaki Y, Harashima S, Sasaki M, Mukai E, Nakamura Y, Harada N, Toyoda K, Hamasaki A, Yamane S, Yamada C, Yamada Y, Seino Y, Inagaki N
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Journal Title
Horm Metab Horm Metab Res
Volume: 42(5):311-317
DOI
Peer Reviewed
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