2012 Fiscal Year Final Research Report
Mechanism of adiponectin binding proteinson vascularmetabolism.
| Project/Area Number |
22590978
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka University |
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Principal Investigator |
KIHARA Shinji 大阪大学, 大学院・医学系研究科, 教授 (20332736)
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| Co-Investigator(Kenkyū-buntansha) |
FUNAHASHI Tohru 大阪大学, 大学院・医学系研究科, 寄附講座教授 (60243234)
MAEDA Norikazu 大阪大学, 大学院・医学系研究科, 助教 (30506308)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 内科 / 脂質 / 蛋白質 / 細胞・組織 / 生体分子 |
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| Research Abstract |
Cystatin C was identified as an adiponectin binding protein. In macrophage, adiponectin regulated vascular endothelial growth factor-C. In vascular endothelial cell culture, cystatin C abrogated the anti-inflammatory effects of adiponectin. The clearance rate of adiponectin was decreased by cystatin C in mouse model. Although adiponectin has anti-atherogenic properties, hyper-adiponectinemia in renal failure is associated with increased risk of atherosclerosis. The present findings suggest that the high cystatin C level of renal failure impaired vascular metabolism through the direct binding with adiponectin.
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