Analysis of tissue accumulation and regulation of adiponectin

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590979
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Osaka University
• Principal Investigator: MAEDA Norikazu 大阪大学, 医学系研究科, 助教 (30506308)
• Project Period (FY): 2010 – 2012
• Keywords: 内科 / 糖尿病 / 蛋白質

Research Abstract

Adenovirus-mediated supplement of adiponectin to adiponectin-deficient mice demonstrated that adiponectin was accumulated in the heart tissue and exhibited cardio-protective role. S100A8 was identified as a novel adipocytokine from mice white adipose tissue by cDNA microarray analysis. Glucocorticoid was one of regulators for adiponectin expression and its regulatory mechanism was clarified in present study.

Research Products

• [Journal Article] Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice (2013)
  • Author(s): Shiota A, Shimabukuro M, Fukuda D, Soeki T, Sato H, Uematsu E, Hirata Y, Kurobe H, Maeda N, Sakaue H, Masuzaki H, Shimomura I, Sata M
  • Journal Title: Cardiovasc Diabetol Volume: 11 Pages: 139
  • DOI: DOI:10.1186/1475-2840-11-139.
  • Peer Reviewed
• [Journal Article] Contribution of glucocorticoid-mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction (2012)
  • Author(s): Hirata A, Maeda N, Nakatsuji H, Hiuge-Shimizu A, Okada T, Funahashi T, Shimomura I
  • Journal Title: Biochem Biophys Res Commun Volume: 419 Pages: 182-187
  • DOI: DOI:10.1016/j.bbrc.2012.01.139
  • Peer Reviewed
• [Journal Article] Adiponectin G276T gene polymorphism is associated with cardiovascular disease in Japanese patients with type 2 diabetes. (2012)
  • Author(s): Katakami N, Kaneto H, Matsuoka TA, Takahara M, Maeda N, Shimizu I, Ohno K, Osonoi T, Kawai K, Ishibashi F, Imamura K, Kashiwagi A, Kawamori R, Matsuhisa M, Funahashi T, Yamasaki Y, Shimomura I.
  • Journal Title: Atherosclerosis. Volume: 220 Pages: 437-442
  • DOI: DOI:10.1016/j.atherosclerosis.2011.11.010.
  • Peer Reviewed
• [Journal Article] Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes (2011)
  • Author(s): Inoue K, Maeda N, Kashine S, Fujishima Y, Kozawa J, Hiuge-Shimizu A, Okita K, Imagawa A, Funahashi T, Shimomura I.
  • Journal Title: Cardiovasc Diabetol Volume: 10 Pages: 109
  • DOI: DOI:10.1186/1475-2840-10-109
  • Peer Reviewed
• [Journal Article] Induced adipocyte cell-sheet ameliorates cardiac dysfunction in a mouse myocardial infarction model: a novel drug delivery system for heart failure. (2011)
  • Author(s): Imanishi Y, Miyagawa S, Maeda N, Fukushima S, Kitagawa-Sakakida S, Daimon T, Hirata A, Shimizu T, Okano T, Shimomura I, Sawa Y
  • Journal Title: Circulation. Volume: 124 Pages: S10-17
  • DOI: DOI:10.1161/CIRCULATIONAHA.110.009993.
  • Peer Reviewed