2012 Fiscal Year Final Research Report
Mechanism of browning of white adipocyte and growing of atherosclerotic plaque
| Project/Area Number |
22590998
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI So 北海道大学, 北海道大学病院, 助教 (70507590)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 代謝異常症 / 肥満症 / 動脈硬化 |
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| Research Abstract |
Our findings demonstrate a novel role for PLIN1 expression in adipose tissue metabolism and regulation of obesity and its metabolic complications. Overexpression of PLIN1 in white adipocytes reduces lipid droplet size by decreasing the expression of other lipid droplet proteins like FSP27 and thereby inducing a brown adipose tissue-like phenotype.In the other study, we investigated the relationship between macrophage polarity and the vulnerability of human atherosclerotic plaques and clinical events. Macrophage polarity of atherosclerotic plaques was associated with clinical incidence of ischemic stroke, and unstable plaques defined by ultrasound.
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[Journal Article] Ovarian morphology and prevalence of polycystic ovary syndrome in Japanese women with type1 diabetes mellitus2013
Author(s)
Miyoshi A, Nagai S, Takeda M, Kondo T, Nomoto H, Kameda H, Hirai A, Cho K, Kimachi K, Shimizu C, Atsumi T, Miyoshi H.
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Journal Title
J Diabetes Invest
Volume: (in press)
Peer Reviewed
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[Journal Article] Perilipin overexpression in mice protects against diet-induced obesity2010
Author(s)
Miyoshi H, Souza SC, Endo M, Sawada T , Perfield JW 2nd , Shimizu C , Stancheva Z, Nagai S, Strissel KJ, Yoshioka N , Obin MS , Koike T , Greenberg AS
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Journal Title
J Lipid Res
Volume: 51(5)
Pages: 975-82
Peer Reviewed
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