2012 Fiscal Year Final Research Report
Effect of RAGE on the interaction between osteoblasts and osteoclasts and its epigenetic regulation
| Project/Area Number |
22590999
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TATSUNO Ichiro 東邦大学, 医療センター佐倉病院, 教授 (80282490)
TANAKA Tomoaki 千葉大学, 大学院・医学研究院, 講師 (50447299)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 糖尿病 / シグナル伝達 / エピジェネティクス / 骨リモデリング / 破骨細胞 |
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| Research Abstract |
The receptor for AGEs (RAGE) is implicated in the progression of diabetic complications. We were interested in determining the influence of RAGE on bone metabolism. In the experiments using pre-osteoclastic RAW264.7 cells and pre-osteoblastic MC3T3-E1 cells, ligand-induced activation of RAGE-stimulates osteoclastogenesis through factors secreted from osteoblasts. Each NFATc1-downstream gene has a different timing of its peak expression, suggesting stage-specific regulation of the each NFATc1 target genes.
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