2012 Fiscal Year Final Research Report
The effect of progranulin, a novel ApoA1-binding protein, on the plaque rapture and the mechanism of dementia onset
| Project/Area Number |
22591000
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka University |
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Principal Investigator |
OHAMA Tohru 大阪大学, 保健センター, 助教 (20467583)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Shizuya 大阪大学, 大学院・医学系研究科, 准教授 (60243242)
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| Project Period (FY) |
2010 – 2012
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| Keywords | プログラニュリン / HDL / 動脈硬化 / 急性冠症候群 / 痴呆 |
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| Research Abstract |
PGRN KO mice exhibited lipid abnormality such as higher plasma triglyceride and lower ability of HDL to take up cholesterol. In addition, we crossed PGRN KO mice with ApoE KO mice to generate PGRN-/-ApoE-/- (double KO, DKO) mice. DKO mice showed much more pronounced atherosclerosis compared with ApoE KO mice. Moreover, PGRN concentration in the blood collected from the culprit lesion in the acute phase of ACS was lower than that in the peripheral blood and in chronic phase of ACS, suggesting that PGRN might be associated with the plaque stability.
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