2012 Fiscal Year Final Research Report
Role of ABCA1/G1 proteon degradation on HDL-mediated anti-atherogenesis
| Project/Area Number |
22591003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | National Defense Medical College |
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Principal Investigator |
AYAORI Makoto 防衛医科大学校, 病院, 助教 (70532464)
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| Co-Investigator(Kenkyū-buntansha) |
IKEWAKI Katsunori 防衛医科大学校, 医学教育部医学科専門課程, 教授 (40287199)
HISADA Tetsuya 防衛医科大学校, 医学教育部医学科専門課程, 助教 (70573856)
KONDO Harumi 防衛医科大学校, 医学教育部医学科専門課程, 助教 (80401602)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子生物学 |
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| Research Abstract |
We demonstrated that ABCA1/G1 was degraded via polyubiquitination in the ubiquitin-proteasome system (UPS). Furthermore, inhibition of the UPS using proteasome inhibitors enhanced both apoA-I- and HDL-mediated cholesterol efflux from macrophages by increasing ABCA1/G1 expressions. Finally, bortezomib, a proteasome inhibitor, promoted overall RCT in vivo in mice. These findings may ultimately provide the basis for a novel therapeutic strategy for atherosclerotic diseases.
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[Journal Article] Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport2013
Author(s)
Nakaya N, Ayaori M, Uto-Kondo H, Sotherden GM, Nishida T, Katamoto H, Miura Y, Takiguchi S, Yakushiji E, Iizuka M, Ogura M, Sasaki M, Yogo M, Komatsu T, Adachi, T Maruyama C, Ikewaki K
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Journal Title
URL
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[Journal Article] Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages2012
Author(s)
Ayaori M, Yakushiji E, Ogura M, Nakaya K, Hisada T, Uto-Kondo H, Takiguchi S, Terao Y, Sasaki M, Komatsu T, Iizuka M, Yogo M, Uehara Y, Kagechika H, Nakanishi T, Ikewaki K.
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Journal Title
Biochim Biophys Acta
Volume: 1821(4)
Pages: 561-72
DOI
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[Journal Article] Proteasomal inhibition promotes ATP-binding cassette transporter A1 (ABCA1) and ABCG1 expression and cholesterol efflux from macrophages in vitro and in vivo2011
Author(s)
Ogura M, Ayaori M, Terao Y, Hisada T, Iizuka M, Takiguchi S, Uto-Kondo H, Yakushiji E, Nakaya K, Sasaki M, Komatsu T, Ozasa H, Ohsuzu F, Ikewaki K.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 31
Pages: 1980-1987
DOI
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