2012 Fiscal Year Final Research Report
Elucidation of the roles of Neuromedin U on development of atherosclerosis and its therapeutic application
| Project/Area Number |
22591004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
SHIBA Mariko 独立行政法人国立循環器病研究センター, 研究所, 部長 (70271575)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ニューロメジンU / 動脈硬化 / モデル動物 |
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| Research Abstract |
In order to study the effect of NMU on cholesterol metabolism and development of atherosclerosis, double knockout mice of NMU and Apolipoprotein E was synthesized. Apo E and NMU double knockout mice showed severe hypercholesterolemia, the development of atherosclerosis and survival curve showed almost the same. NMU was shown to have significant roles in cholesterol metabolism and development of atherosclerosis.
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[Journal Article] Multicenter study to determine the diagnosis criteria of heterozygous familial hypercholesterolemia in Japan2012
Author(s)
Harada-Shiba M, Arai H, Okamura T, Yokote K, Oikawa S, Nohara A, Okada T, Ohta T, Bujo H, Watanabe M, Wakatsuki A, Yamashita S
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Journal Title
J Atheroscler Thromb
Volume: 19(11)
Pages: 1019-1026
Peer Reviewed
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