2012 Fiscal Year Final Research Report
G-protein coupled receptors: functional selectivity and disease
| Project/Area Number |
22591008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MAKITA Noriko 東京大学, 医学部附属病院, 助教 (60353455)
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| Co-Investigator(Kenkyū-buntansha) |
IIRI Tarho 東京大学, 医学部附属病院, 特任講師 (90313022)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 受容体 / G タンパク質 / 機能選択性 / 疾患 / 制御 / G タンパク質共役受容体 |
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| Research Abstract |
We examined functional selectivity of GPCR signalings, focusing on analysis of disease and ligand action against GPCRs: action of autoantibody working selectively against calcium-sensing receptor, unique action of ligands against novel V2 receptor mutants causing partial nephrogenic diabetes insipidus, drugs targeting selective inactivation, and cross-talk of GPCR signalings.
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[Journal Article] Attenuated desensitization of β-adrenergic receptor by water-soluble -nitrosamines that induce S-nitrosylation without NO release.2013
Author(s)
Makita N, Kabasawa Y, Otani Y, Firman, Sato J, Hashimoto M, Nakaya M, Nishihara H, Nangaku M, Kurose H, Ohwada T, Iiri T.
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Journal Title
Circ Res.
Volume: 112
Pages: 327-34
Peer Reviewed
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[Journal Article]2013
Author(s)
Makita N and Tiiri T.
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Journal Title
Tyrosine kinase induced thyroid disorder-review and hypothesis Thyroid
Volume: 23
Pages: 151-9
Peer Reviewed
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[Journal Article] V2 vasopressin receptor (V2R) mutations in partial nephrogenic diabetes insipidus highlight protean agonism of V2R antagonists.2012
Author(s)
Takahashi K, Makita N, Manaka K, Hisano M, Akioka Y, Miura K, Takubo N, Iida A, Ueda N, Hashimoto M, Fujita T, Igarashi T, Sekine T, Iiri T.
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Journal Title
J Biol Chem.
Volume: 287
Pages: 2099-106
Peer Reviewed
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