2012 Fiscal Year Final Research Report
The role of chemerin in the development of diabetes
| Project/Area Number |
22591012
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Yutaka 神戸大学, 医学研究科, 講師 (70301281)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 糖尿病 / アディポカイン / ケマリン |
|---|
| Research Abstract |
We identified chemerin as a novel adipokine (FEBS letters2008 582: 573-578). We further analyzed the physiological function of chemerin using chemeirn-deficient mice. We have shown that chemerin regulates ・-cell function and plays an important role in glucose homeostasis in a tissue-dependent manner （ Scientific Reports2011 1 123 DOI:10.1038/srep00123 . We have also demonstrated that serum chemerin concentrations are associated with the development of diabetes in humans (Endocrine J2012 60 37).
|
-
-
-
-
-
[Journal Article] Nonalcoholic fatty liver disease in adult hypopituitary patients with growth hormone deficiency and the impact of growth hormone replacement therapy2012
Author(s)
Nishizawa H, Iguchi G, Murawaki A, Fukuoka H, Hayashi Y, Kaji H, Yamamoto M, Suda K, Takahashi M, Seo Y, Yano Y, Kitazawa R, Kitazawa S, Koga M, Okimura Y, Chihara K, Takahashi Y
-
Journal Title
Eur J Endocrinol
Volume: 167
Pages: 67-74
Peer Reviewed
-
[Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans2012
Author(s)
Nishizawa H, Handayaningsih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Hakuno F, Yamanouchi K, Nishihara M, Seino S, Takahashi S, Takahashi Y
-
Journal Title
Growth Horm IGF Res
Volume: 22(2)
Pages: 64-8
Peer Reviewed
-
[Journal Article] Chemerin regulates β-cell function in mice.2011
Author(s)
Takahashi M, Okimura Y, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Kitazawa R, Fujimoto W, Takahashi K, Zolotaryov FN, Hong KS, Kiyonari H, Abe T, Kaji H, Kitazawa S, Kasuga M, Chihara K, Takahashi Y.
-
Journal Title
Scientific Reports
Volume: 1
DOI
Peer Reviewed
-
[Journal Article] Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes2011
Author(s)
Handayaningshi AE, Iguchi G, Fukuoka H, Nishizawa H, Takahashi M, Yamamoto M, Herningtyas HE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
-
Journal Title
Endocrinology
Volume: 152
Pages: 912-21
Peer Reviewed
-
[Journal Article] Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody in humans2011
Author(s)
Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano S, Takahashi M, Nishizawa H, Handayaningshi AE, Fukuoka H, Tobita M, Saitoh T, Tojo T, Mokubo A, Morinobu A, Iida K, Kaji H, Seino S, Chihara K, Takahashi Y
-
Journal Title
J Clin Invest
Volume: 121
Pages: 113-9
Peer Reviewed
-
-
[Journal Article] IGF-I stimulates reactive oxygen species (ROS) production and inhibits insulin-dependent glucose uptake via ROS in 3T3-L1 adipocytes2010
Author(s)
Fukuoka H, Iida K, Nishizawa H, Imanaka M, Takeno R, Iguchi G, Takahashi M, Okimura Y, Kaji H, Chihara K, Takahashi Y
-
Journal Title
Growth Horm IGF Res
Volume: 20
Pages: 212-219
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] A case of gigantism associated with a missense mutation in SOCS2gene2011
Author(s)
Suda K, Iguchi G, Yamamoto M, Handayaningsih AE, Nishizawa H, Takahashi M, Okimura Y, Kaji K, Chihara K, Takahashi Y.
Organizer
The 93th Annual Meeting of the Endocrine Society
Place of Presentation
Boston, USA (Abstract award)
Year and Date
20110604-07
-
[Presentation] Novel autoimmune polyendocrine syndrome: Adult combined GH,prolactin and TSH deficiency associated with circulating PIT-1 antibody.2011
Author(s)
Takahashi Y, Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano T, Takahashi M, Nishizawa H, Handayaningsih AE, Tojo K, Mokubo A, Iida K, Kaji K, Chihara K
Organizer
The 93th Annual Meeting of the Endocrine Society
Place of Presentation
Boston, USA
Year and Date
20110604-07
-
[Presentation] Sirt1 negatively regulates IGF-I production by growth hormone in hepatocytes2010
Author(s)
Yamamoto M, IguchiG, Fukuoka H, Takahashi M, Nishizawa H, Handayaningsih AE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
Organizer
The 5thinternational congress of the GRS and the IGF society
Place of Presentation
New York, USA
Year and Date
20101003-07
-
[Presentation] Sirt1 negatively regulates IGF-I production by growth hormone in hepatocytes2010
Author(s)
Yamamoto M, IguchiG, Fukuoka H, Takahashi M, Nishizawa H, Handayaningsih AE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
Organizer
The 14th International Congress of Endocrinology
Place of Presentation
Japan, Kyoto
Year and Date
20100326-30
-
[Presentation] IGF-1 induces cellular senescence via reactive oxygen species in vascular smooth muscle cells.2010
Author(s)
Handayaningsih AE, IguchiG, Fukuoka H, Nishizawa H, Yamamoto M, Herningtyas H, Takahashi M, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y.
Organizer
The 14th International Congress of Endocrinology
Place of Presentation
Japan, Kyoto
Year and Date
20100326-30
-
[Presentation] GH and IGF-Iameliorate inflammation and fibrosis in nonalcoholic steatohepatitis mouse model2010
Author(s)
Nishizawa H, IguchiG, Takahashi M, Yamamoto M, Handayaningsih AE, Kitazawa R, Okimura Y, Kaji H, Kitazawa S, Hayashi Y, Chihara K, Seino S, Takahashi Y.
Organizer
The 14th International Congress of Endocrinology
Place of Presentation
Japan, Kyoto
Year and Date
20100326-30
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
