2012 Fiscal Year Final Research Report
The production mechanism and role of progesterone in female mouse adrenal cortex.
| Project/Area Number |
22591015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Nara Medical University |
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Principal Investigator |
HATANO Osamu 奈良県立医科大学, 医学部, 講師 (40164850)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEMORI Hiroshi 独立行政法人医薬基盤研究所, その他部局等, プロジェクトリーダー (90273672)
NISHI Mayumi 奈良県立医科大学, 医学部, 教授 (40295639)
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| Co-Investigator(Renkei-kenkyūsha) |
NONAKA Yasuki 大阪青山大学, 健康科学部, 教授 (80156215)
OHTA Miho 相愛大学, 人間発達学部, 教授 (90132935)
OHNISHI Ken 茨城県立医療大学, 保険医療学部, 教授 (50152195)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 内分泌学 |
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| Research Abstract |
In the adrenal cortex of female mice, we found the zone in which CYP11B1/B2 and CYP21 could not be detected. This zone is contiguous to adrenal medulla. In the zone, steroid hormone producing enzymes which are involved in the production of progesterone were expressed. In aromatase-deficient female mice, the contiguous region to adrenal medulla expressed CYP11B1(/B2), suggesting the role of estrogen in the formation of this zone.
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[Journal Article] Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice2012
Author(s)
Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nishi M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H
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Journal Title
PLoS One
Volume: 7(5)
Pages: e37803
Peer Reviewed
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[Journal Article] SIK2 is a new key regulator for neuronal survival after ischemia via TORC1-CREB2011
Author(s)
Sasaki T, Takemori H, Yagita Y, Terasaki Y, Uebi T, Horike N, Takagi H, Susumu T, Teraoka H, Kusano K, Hatano O, Oyama N, Sugiyama Y, Sakoda S, Kitagawa K.
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Journal Title
Neuron
Volume: 69(1)
Pages: 106-119
Peer Reviewed
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[Journal Article] Downregulation of SIK2 expression promotes the melanogenic program in mice2010
Author(s)
Horike N, Kumagai A, Shimono Y, Onishi T, Itoh Y, Sasaki T, Kitagawa K, Hatano O, Takagi H, Susumu T, Teraoka H, Kusano KI, Nagaoka Y, Kawahara H, Takemori H.
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Journal Title
Cell Melanoma Res
Volume: 23(6)
Pages: 809-819
Peer Reviewed
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