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2012 Fiscal Year Final Research Report

Analysis of estrogen signaling specific and/or common to brainfunction and cancer, and its clinical relevance

Research Project

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Project/Area Number 22591016
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionSaitama Medical University

Principal Investigator

IKEDA Kazuhiro  埼玉医科大学, 医学部, 講師 (30343461)

Research Collaborator INOUE Satoshi  埼玉医科大学, 医学部, 客員教授 (40251251)
Project Period (FY) 2010 – 2012
Keywordsエストロゲン / 脳 / がん / 転写 / 遺伝子
Research Abstract

Estrogen plays important roles in brain function and breast cancer. In this study, I aimed to explore the novel estrogen-responsive genes in brain and cancer tissues for identifying specific and/or common estrogen signaling pathway between these tissues. In addition to estrogen-responsive genes that we have previously reported, clinical relevance of these estrogen-responsive genes is also explored. We identified novelestrogen-responsive genes specific in hippocampus, hypothalamus and brain stem. These novel estrogen-responsive genes are known to be associated with breast cancer. We also demonstrated that the expression of transcription factors, FOXA1 and FOXP1 is induced by estrogen in breast cancer cells and immunoreactivities of FOXA1 and FOXP1 are positively correlated with good prognosis of breast cancer patients with tamoxifen treatment. These findings would uncover novel role of estrogen signaling in brain function and cancers.

  • Research Products

    (23 results)

All 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Conditional expression of constitutively active estrogen receptor α in chondrocytes impairs longitudinal bone growth in mice2012

    • Author(s)
      Ikeda K, Tsukui T, Imazawa Y, Horie-Inoue K, Inoue S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 425 Pages: 912-917

    • DOI

      DOI:10.1016/j.bbrc.2012.07.170

    • Peer Reviewed
  • [Journal Article] Forkhead box transcription factor, forkhead box A1, shows negative association with lymph node status in endometrial cancer, and represses cell proliferation and migration of endometrial cancer cells2012

    • Author(s)
      Abe Y, Ijichi N, Ikeda K, Kayano H, Horie-Inoue K, Takeda S, Inoue S
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 806-812

    • DOI

      DOI:10.1111/j.1349-7006.2012.02201.x

    • Peer Reviewed
  • [Journal Article] TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer2012

    • Author(s)
      Takayama K, Horie-Inoue K, Suzuki T, Urano T, Ikeda K, Fujimura T, Takahashi S, Homma Y, Ouchi Y, Inoue S
    • Journal Title

      Mol Endocrinol

      Volume: 26 Pages: 748-761

    • DOI

      DOI:10.1210/me.2011-1242

    • Peer Reviewed
  • [Journal Article] Conditional expression of human bone Gla protein in osteoblasts causes skeletal abnormality in mice2012

    • Author(s)
      Ikeda K, Tsukui T, Tanaka D, Maruyama Y, Horie-Inoue K, Inoue S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 424 Pages: 164-169

    • DOI

      DOI:10.1016/j.bbrc.2012.06.098

    • Peer Reviewed
  • [Journal Article] Association of double-positive FOXA1 and FOXP1 immunoreactivities with favorable prognosis of tamoxifen-treated breast cancer patients2012

    • Author(s)
      Ijichi N, Shigekawa T, Ikeda K,Horie-Inoue K, Shimizu C, Saji S, Aogi K, Tsuda H, Osaki A, Saeki T, Inoue S
    • Journal Title

      Horm Cancer

      Volume: 3 Pages: 147-159

    • DOI

      DOI:10.1007/s12672-012-0111-0

    • Peer Reviewed
  • [Journal Article] Conditional expression of constitutively active estrogen receptor α in osteoblasts increases bone mineral density in mice2011

    • Author(s)
      Ikeda K, Tsukui T, Horie-Inoue K, Inoue S
    • Journal Title

      FEBS Let

      Volume: 585 Pages: 1303-1309

    • DOI

      DOI:10.1016/j.febslet.2011.03.038

    • Peer Reviewed
  • [Journal Article] FOXP1, an estrogen-inducible transcription factor, modulates cell proliferation in breast cancer cells and 5-year recurrence-free survival of patients with tamoxifen-treated breast cancer2011

    • Author(s)
      Shigekawa T, Ijichi N, Ikeda K, Horie-Inoue K, Shimizu C, Saji S, Aogi K, Tsuda H, Osaki A, Saeki T, Inoue S
    • Journal Title

      Horm Cancer

      Volume: 2 Pages: 286-297

    • DOI

      DOI:10.1007/s12672-011-0082-6

    • Peer Reviewed
  • [Journal Article] Estrogen-related receptor γ modulates cell proliferation and estrogen signaling in breast cancer2011

    • Author(s)
      Ijichi N, Shigekawa T, Ikeda K, Horie-Inoue K, Fujimura T, Tsuda H, Osaki A, Saeki T, Inoue S
    • Journal Title

      J Steroid Biochem Mol Biol

      Volume: 123 Pages: 1-7

    • DOI

      DOI:10.1016/j.jsbmb.2010.09.002

    • Peer Reviewed
  • [Journal Article] Integrated Quantitative Analysis of the Phosphoproteome and Transcriptome in Tamoxifen-Resistant Breast Cancer2011

    • Author(s)
      Oyama M, Nagashima T, Suzuki T, Kozuka-Hata H, Yumoto N, Shiraishi Y, Ikeda K, Kuroki Y, Gotoh N, Ishida T, Inoue S, Kitano H, Okada-Hatakeyama M
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 818-829

    • DOI

      DOI:10.1074/jbc.M110.156877

    • Peer Reviewed
  • [Journal Article] Integration of cap analysis of gene expression and chromatin immunoprecipitation analysis on array reveals genome-wide androgen receptor signaling in prostate cancer cells2011

    • Author(s)
      Takayama K, Tsutsumi S, Katayama S, Okayama T, Horie-Inoue K, Ikeda K, Urano T, Kawazu C, Hasegawa A, Ikeo K, Gojyobori T, Ouchi Y, Hayashizaki Y, Aburatani H, Inoue S
    • Journal Title

      Oncogene

      Volume: 30 Pages: 619-630

    • DOI

      DOI:10.1038/onc.2010.436

    • Peer Reviewed
  • [Journal Article] Knock-down of Efp by DNA-modified small interfering RNA inhibits breast cancer cell proliferation and in vivo tumor growth2010

    • Author(s)
      Ueyama K, Ikeda K, Sato W, Nakasato N, Horie-Inoue K, Takeda S, Inoue S
    • Journal Title

      Cancer Gene Ther

      Volume: 17 Pages: 624-632

    • DOI

      DOI:10.1038/cgt.2010.19

    • Peer Reviewed
  • [Journal Article] A-sequencing of MCF-7 breast cancer cells identifies novel estrogen-responsive genes with functional estrogen receptor-binding sites in the vicinity of their transcription start sites

    • Author(s)
      Yamaga R, Ikeda K, Horie-Inoue K, Ouchi Y, Suzuki Y, Inoue S
    • Journal Title

      Horm Cancer (in press)

    • DOI

      DOI:10.1007/s12672-013-0140-3

    • Peer Reviewed
  • [Presentation] Cytochrome c oxidase subunit 7 related protein はミトコンドリアの呼吸活性を制御し、生体におけるエネルギー代謝に関与する2012

    • Author(s)
      池田和博、堀江公仁子、井上聡
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      20121214-16
  • [Presentation] MicroRNA profiling of tamoxifen-sensitive and -resistant breast cancer MCF-7 cells analyzed by deep sequencing2012

    • Author(s)
      Ikeda K, Horie-Inoue K, Mano H, Inoue S
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      Ishikawa, Japan
    • Year and Date
      20121115-17
  • [Presentation] 前立腺がん細胞における内分泌療法耐性獲得に関与するマイクロ RNA の探索2012

    • Author(s)
      池田和博 、宮崎利明、堀江公仁子、岡本康司、井上聡
    • Organizer
      第20回日本ステロイドホルモン学会
    • Place of Presentation
      石川市
    • Year and Date
      2012-11-18
  • [Presentation] Estrogen-dependent transcriptome analysis in breast cancer MCF-7 cells by RNA-sequencing2011

    • Author(s)
      Ikeda K, Yamaga R, Horie-Inoue K, Suzuki Y, Inoue S
    • Organizer
      EMBO Conference, Nuclear Receptors
    • Place of Presentation
      Sitges, Barcelona, Spain
    • Year and Date
      20110916-20
  • [Presentation] 活性型エストロゲン受容体はコンディショナルトランスジェニックマウスの骨芽細胞ならびに軟骨細胞において異なる in vivo 作用を示す2011

    • Author(s)
      池田和博、堀江公仁子、 井上聡
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      20110728-30
  • [Presentation] 乳がん細胞における全ゲノムレベルでのエストロゲン応答性転写開始点の探索と応答因子の機能解析2011

    • Author(s)
      池田和博、山賀亮之介、堀江公仁子、 井上聡
    • Organizer
      第19回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-11-26
  • [Presentation] 乳がんならびに子宮内膜がんにおけるフォークヘッド転写因子 FOXA1 の機能と臨床的意義2011

    • Author(s)
      伊地知暢広、重川崇、阿部弥生、 池田和博、堀江公仁子、茅野秀一、津田均、大崎昭彦、竹田省、佐伯俊昭、井上聡
    • Organizer
      第19回日本ステロイドホルモン学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-11-26
  • [Presentation] 骨芽細胞において活性型エストロゲン受容体を過剰発現するマウスは骨密度の増加を示す2010

    • Author(s)
      池田和博、津久井通、堀江公仁子、 井上聡
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Year and Date
      20101207-10
  • [Presentation] 活性型エストロゲン受容体を軟骨細胞で発現するトランスジェニックマウスの解析2010

    • Author(s)
      池田和博、津久井通、堀江公仁子、 井上聡
    • Organizer
      第18回日本ステロイドホルモン学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-11-27
  • [Presentation] エストロゲン関連受容体 ERRg は乳がんにおける細胞増殖とエストロゲンシグナル経路を調節する2010

    • Author(s)
      伊地知暢広、重川崇、 池田和博、堀江公仁子、津田均、大崎昭彦、佐伯俊昭、井上聡
    • Organizer
      第18回日本ステロイドホルモン学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-11-27
  • [Remarks]

    • URL

      http://www.saitama-med.ac.jp/genome/Div02_GRST/index.html

URL: 

Published: 2014-08-29  

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