2012 Fiscal Year Final Research Report
Analysis of oncogenic mechanisms incuced by receptor tyrosine kinase receptor, ROR1
| Project/Area Number |
22591031
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
FUKUDA Tetsuya 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (70332624)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | RORI / CLL |
|---|
| Research Abstract |
We analyzed the transcriptional regulation of ROR1 and found that MYB induced the ROR1 expression in malignant cells. In parallel, we did ex vivo expansion of ROR1-specific cytotoxic T lymphocytes by engineered artificial antigen presenting cells expressing CD137 ligand co-stimulatory molecule
|
Research Products
(4 results)
