• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

The Role of the Lyn-PI 3-kinase signaling pathways and PKM2 in the myeloma cell proliferation

Research Project

  • PDF
Project/Area Number 22591039
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionSenri Kinran University (2012)
Yamaguchi University (2010-2011)

Principal Investigator

ISHIKAWA Hideaki  千里金蘭大学, 生活科学部, 教授 (40294623)

Project Period (FY) 2010 – 2012
Keywords骨髄腫 / IL-6 / Lyn / PI 3-kinase / Akt / FoxO1 / NF-kB / 解糖系
Research Abstract

In addition to the activation of both signal transducer and activator of transcription (STAT) 3 and extracellular signal-regulated kinase (ERK)1/2, the CD45-Lyn-mediating activation of the phosphoinositide (PI) 3-kinase-Akt signaling pathways appear to be important for the IL-6 induced proliferation of myeloma cells.

  • Research Products

    (9 results)

All 2013 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Book (2 results)

  • [Journal Article] 骨髄腫細胞のシグナル伝達2012

    • Author(s)
      石川秀明
    • Journal Title

      医学のあゆみ

      Volume: Vol. 242, No. 13 Pages: 1027-1032

    • URL

      http://www.ishiyaku.co.jp/

  • [Journal Article] A novel signaling pathway associated with Lyn,PI3-kinase and Akt supports the proliferation of myeloma cells2010

    • Author(s)
      Mohd S. Iqbal, Naohiro Tsuyama , Masanori Obata and Hideaki Ishikawa
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: Vol. 392, No. 3 Pages: 415-420

    • DOI

      DOI:10.1016/j.bbrc.2010.01.038

    • Peer Reviewed
  • [Presentation] IL-6-induced phosphorylation of FoxO1 as a target of the PI-3-kinase-Akt pathway in myeloma cells(骨髄腫細胞における IL-6 刺激後 PI3-kinase-Akt 刺激伝達系標的分子 FoxO1 の リン酸化)2011

    • Author(s)
      石川秀明、小幡雅則
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-16
  • [Presentation] IL-6-induced phosphorylation ofAkt and FoxO1 in human myeloma cell lines(IL-6 刺激後の骨髄腫細胞における Akt と FoxO1 のリン酸化)2011

    • Author(s)
      石川秀明
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
  • [Presentation] Lyn-PI 3-kinase-Akt 刺激伝達系によ る骨髄腫細胞の増殖機構2010

    • Author(s)
      石川秀明 、Mohd S. Iqbal、津山尚宏、小幡雅則
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
  • [Presentation] The Lyn,PI 3-kinase and Akt signaling pathway supports the proliferation of humanmyeloma cells(Lyn-PI3 kinase-Akt 刺激伝達系はヒト骨髄腫細胞の増殖を促進する)2010

    • Author(s)
      石川秀明、Mohd S. Iqbal,、津山尚宏、小幡雅則
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
  • [Presentation] The IL-6-mediated signaling pathway associated with Lyn,PI 3-kinase and Akt supports the proliferation of human myeloma cells2010

    • Author(s)
      Hideaki Ishikawa, Mohd S. Iqbal, Naohiro Tsuyama and Masanori Obata
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-24
  • [Book] 別冊日本臨牀血液症候群III-その他の血液疾患を含めて-第2版2013

    • Author(s)
      石川秀明
    • Total Pages
      519-535
    • Publisher
      日本臨牀社
  • [Book] 多発性骨髄腫治療マニュアル2012

    • Author(s)
      石川秀明
    • Total Pages
      28-35
    • Publisher
      南江堂

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi