2012 Fiscal Year Final Research Report
Analysis of the regulatory mechanism for differentiation and functionof macrophages using a novel cytokine IL-34
| Project/Area Number |
22591041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kumamoto University |
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Principal Investigator |
SUZU Shinya 熊本大学, エイズ学研究センター, 准教授 (80363513)
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| Research Collaborator |
CHIHARA Takashi 熊本大学, エイズ学研究センター, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Keywords | マクロファージ / 分化 / サイトカイン |
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| Research Abstract |
Macrophages are important hematopoietic immune cells that regulateinnate immunity, and their differentiation and function are regulated by functionalproteins called cytokines. A major cytokine identified so far is M-CSF, but it has beenrecently found that another cytokine IL-34 also regulates macrophage differentiation andfunction. In this study, we revealed that these two cytokines differentially regulatedmacrophages, suggesting that M-CSF and IL-34 have different in vivo role
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[Journal Article] HIV-1 Nef perturbs the function,structure, and signaling of the Golgithrough the Src kinase Hck2012
Author(s)
Hiyoshi M, Takahashi-Makise N,Yoshidomi Y, Chutiwitoonchai N, ChiharaT, Okada M, Nakamura N, Okada S, Suzu S
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Journal Title
Journal ofCellular Physiology
Volume: 227
Pages: 1090-1097
Peer Reviewed
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[Journal Article] Small moleculeinhibition of HIV-1-induced MHC-Idownregulation identifies a temporallyregulated switch in Nef action2010
Author(s)
Dikeakos JD, Atkins KM, Thomas L,Emert-Sedlak L, Byeon IL, Jung J, Ahn J,Wortmann MD, Kukull B, Saito M, KoizumiH, Williamson DM, Hiyoshi M, Barklis E,Takiguchi M, Suzu S, Gronenborn AM,Smithgall TE, Thomas G
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Journal Title
Molecular Biology of the Cell
Volume: 21
Pages: 3279-3292
Peer Reviewed
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