Elucidation of chemoresistance in hypoxic condition and a developmentof radical treatment in AML cells by hypoxia specific inhibitory drugs

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kagawa University (2011-2012); University of Miyazaki (2010)
• Principal Investigator: MATSUNAGA Takuya 香川大学, 医学部, 教授 (70260768)
• Co-Investigator(Kenkyū-buntansha): SHIMODA Kazuya 宮崎大学, 医学部, 教授 (90311844)
• Project Period (FY): 2010 – 2012
• Keywords: 血液腫瘍学 / 抗癌剤耐性

Research Abstract

It was demonstrated that the chemoresistance in hypoxic condition might be a cause of minimal residual disease in bone marrow after chemotherapy in AML.We developed a radical treatment of AML with (i)combination of anticancer drugs and hypoxia specific inhibitory drug, or (ii)combination of anticancer drugs, hypoxia specific inhibitory drug and CAM-DR inhibitory drugs.

Research Products

• [Journal Article] Elevated HIF-1expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy (2012)
  • Author(s): Matsunaga T, Imataki O, Torii E, Kameda T, Shide K, Shimoda H, Kamiunten A, Sekine M,Taniguchi Y, Yamamoto S, Hidaka T, KatayoseK, Kubuki Y, Dobashi H, Bandoh S, OhnishiH, Fukai F, Shimoda K
  • Journal Title: Leuk Res Volume: 36 Pages: e122-124