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2012 Fiscal Year Final Research Report

Analysis of the tumor regulatory molecule, c-Cbl.

Research Project

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Project/Area Number 22591046
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionJichi Medical University

Principal Investigator

SUZUKI Takahiro  自治医科大学, 医学部, 講師 (40345210)

Project Period (FY) 2010 – 2012
Keywords癌 / 細胞骨格 / 未分化造血幹細胞 / Cbl
Research Abstract

c-Cbl is known as a ubiquitin E3 ligase and functions as a negative regulator for signals induced by various activated tyrosine kinases in hematopoietic cells by promoting ubiquitination and proteasomal degradation of these kinases. This negative regulati

  • Research Products

    (32 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) Presentation (10 results) Book (14 results)

  • [Journal Article] Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes.2012

    • Author(s)
      Ueda Y, Mizutani C, Nannya Y, Kurokawa M, Kobayashi S, Takeuchi J, Tamura H, Ogata K, Dan K, Shibayama H, Kanakura Y, Niimi K, Sasaki K, Watanabe M, Emi N, Teramura M, Motoji T, Kida M, Usuki K, Takada S, Sakura T, Ito Y, Ohyashiki K, Ogawa H, Suzuki T, O
    • Journal Title

      Leuk Lymphoma

  • [Journal Article] Flow Cytometric Analysis of Kappa and Lambda Light Chain Expression in Endoscopic Biopsy Specimens before the Diagnosis of B-Cell Lymphoma.2012

    • Author(s)
      Oka S, Muroi K, Sato K, Fujiwara S, Oh I, Matsuyama T, Ohmine K, Suzuki T, Ozaki K, Mori M, Nagai T, Fukushima N, Fukushima N, Tanaka A, Ozawa K.
    • Journal Title

      J Clin Exp Hematop

      Volume: 52(2) Pages: 127-31

  • [Journal Article] Autologous hematopoietic recovery with aberrant antigen expression after allogeneic bone marrow transplantation2012

    • Author(s)
      Kobayashi H, Matsuyama T, Oka S, Fujiwara S, Oh I, Suzuki T, Ozaki K, Mori M, Nagai T, Ozawa K, Muroi K.
    • Journal Title

      J Clin Exp Hematop

      Volume: 52(1) Pages: 81-3

  • [Journal Article] A pilot study of a novel therapy using mesenchymal stromal cells for steroid-resistant graft-versus-host disease2011

    • Author(s)
      Sato K, Muroi K, Oka S, Sasazaki M, Hosonuma R, Ozaki K, Fujiwara S, Oh I, Matsuyama T, Ohmine K, Suzuki T, Mori M, Nagai T, Ozawa K
    • Journal Title

      Jichi Med. Univ.Journal

      Volume: 34 Pages: 149-157

  • [Journal Article] Incidental carcinomas detected by PET/CT scans in patients with malignant lymphoma.2010

    • Author(s)
      Sato K, Ozaki K, Fujiwara S, Oh I, Matsuyama T, Ohmine K, Suzuki T, Mori M, Nagai T, Muroi K, Ozawa K
    • Journal Title

      Int J Hematol

      Volume: 92(4) Pages: 647-50

  • [Journal Article] AA amyloidosis associated with macroglobulinemia.2010

    • Author(s)
      Tatara R, Nagai T, Kobayashi H, Hatano K, Suzuki T, Muroi K, Ozawa K.
    • Journal Title

      Int J Hematol

      Volume: 92(4) Pages: 675-7

  • [Journal Article] Deregulated Intracellular Signaling by Mutated c-CBL in Myeloid Neoplasms2010

    • Author(s)
      Ogawa S, Shih LY, Suzuki T, Otsu M, Naikauch H, Koeffler HP, Sanada M
    • Journal Title

      Clin Cancer Res.

      Volume: 16(15) Pages: 3825-3831

  • [Journal Article]2010

    • Author(s)
      Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP.
    • Journal Title

      Cell Cycle.

      Volume: 9(6) Pages: 1051-1056

  • [Presentation] 鉄過剰症と鉄キレート療法-その病態と診療-2013

    • Author(s)
      鈴木隆浩
    • Organizer
      第60回 日本輸血・細胞治療学会東海支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-02-09
  • [Presentation] 骨髄異形成症候群の現状と将来2012

    • Author(s)
      鈴木隆浩
    • Organizer
      第50回日本癌治療学会学術集会 シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      20121025-27
  • [Presentation] エクリズマブ治療で溶血改善後に患者事情で治療を中止した PNH の一症例2012

    • Author(s)
      鈴木隆浩、上原英輔、岡部 寛、上田真寿、佐藤一也、尾崎勝俊、永井 正、室井一男、小澤敬也
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      20121000
  • [Presentation] The Bone Marrow Hematopoietic Microenvironment is Functionally Impaired in Iron-overloaded Mice2011

    • Author(s)
      Okabe H, Suzuki T, Uehara E, Ueda M, Nagai T, Ozawa K
    • Organizer
      53rdASH Annual Meeting and Exposition
    • Place of Presentation
      SanDiego
    • Year and Date
      20111210-13
  • [Presentation] Impacts of Blood Transfusion and Iron Overload on MDS Patients and Hematopoiesis2011

    • Author(s)
      Suzuki T
    • Organizer
      The 2nd JSH International Symposium 2011 in Nagasaki
    • Place of Presentation
      Nagasaki
    • Year and Date
      20110423-24
  • [Presentation] 骨髄異形成症候群(MDS)の治療選択2010

    • Author(s)
      鈴木隆浩
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20100900
  • [Presentation] Hematopoietic Disturbance in Iron-Overload2010

    • Author(s)
      Okabe H, Suzuki T, Uehara E, Omori T, Ueda M, Nagai T, Sakata Y, Ozawa K
    • Organizer
      The 1st JSH International Symposium 2010 in Akita
    • Place of Presentation
      Akita
    • Year and Date
      20100716-17
  • [Presentation] c-Cbl REGULATES INTERACTION OF IMMATURE HEMATOPOIETIC CELLS WITH THE BONE MARROW MICROENVIRONMENT BY Rac GTPase-MEDIATED CYTOSKELETAL SIGNALS.2010

    • Author(s)
      Uehara E, Suzuki T, Okabe H, Ueda M, Nagai T, Sanada M, Ogawa S, Ozawa K
    • Organizer
      16thAnnual Meeting of JSGT
    • Place of Presentation
      Utsunomiya
    • Year and Date
      20100701-02
  • [Presentation] c-Cbl regulates interaction of hematopoietic cells with the bone marrow microenvironment by Rac-mediated signals

    • Author(s)
      Uehara E, Suzuki T, Sasazaki M, Okabe H, Hatano K, Ueda M, Nagai T, Sanada M, Ogawa S, Ozawa K
    • Organizer
      72th Annual Meeting of JSH
    • Place of Presentation
      Yokohama
    • Year and Date
      00000924-26
  • [Presentation] Hematopoietic Disturbance in Iron-Overload

    • Author(s)
      Okabe H, Suzuki T, Uehara E, Ueda M, Nagai T, Ozawa K
    • Organizer
      72th Annual Meeting of JSH
    • Place of Presentation
      Yokohama
    • Year and Date
      00000924-26
  • [Book] 骨髄形成症候群. 今日の治療と看護(第3版)2013

    • Author(s)
      鈴木隆浩
    • Total Pages
      657-660
    • Publisher
      南江堂
  • [Book] 遺伝性球状赤血球症. 別冊日本臨床 血液症候群 I(第2版)2013

    • Author(s)
      鈴木隆浩
    • Total Pages
      175-178
    • Publisher
      日本臨牀社
  • [Book] 骨髄異形成症候群. 今日の治療指針2013

    • Author(s)
      鈴木隆浩
    • Total Pages
      600-602
    • Publisher
      医学書院
  • [Book] 低リスク MDS の治療方針. EBM血液疾患の治療2012

    • Author(s)
      鈴木隆浩.
    • Total Pages
      15-21
    • Publisher
      中外医学社
  • [Book] 輸血後鉄過剰症に対する鉄キレート療法:予後と造血能の改善効果. Annual Review 2012 血液2012

    • Author(s)
      鈴木隆浩
    • Total Pages
      71-79
    • Publisher
      中外医学社
  • [Book] 自己免疫性溶血性貧血. 今日の治療指針 20122012

    • Author(s)
      鈴木隆浩
    • Total Pages
      571-572
    • Publisher
      医学書院
  • [Book] 鉄過剰症と鉄キレート療法. 最新医学別冊 再生不良性貧血2011

    • Author(s)
      鈴木隆浩
    • Total Pages
      174-183
    • Publisher
      最新医学社
  • [Book] 低リスク MDS の治療. 白血病・リンパ腫・骨髄腫-今日の診断と治療-第4版2011

    • Author(s)
      鈴木隆浩
    • Total Pages
      216-225
    • Publisher
      中外医学社
  • [Book] MDS の化学療法. 骨髄異形成症候群(MDS)診療 up-to-date2011

    • Author(s)
      鈴木隆浩
    • Total Pages
      114-121
    • Publisher
      中外医学社
  • [Book] 自己免疫性溶血性貧血:温式、冷式. 血液専門医テキスト2011

    • Author(s)
      鈴木隆浩
    • Total Pages
      163-166
    • Publisher
      南江堂
  • [Book] 鉄キレート療法. 血液専門医テキスト2011

    • Author(s)
      鈴木隆浩
    • Total Pages
      445-447
    • Publisher
      南江堂
  • [Book] 輸血後鉄過剰症に対する鉄キレート療法. 難治性貧血の診療ガイド(2011

    • Author(s)
      鈴木隆浩
    • Total Pages
      237-245
    • Publisher
      南江堂
  • [Book] 鉄キレート療法. 骨髄異形成症候群(MDS)のマネジメント2011

    • Author(s)
      鈴木隆浩
    • Total Pages
      117-124
    • Publisher
      医薬ジャーナル社
  • [Book] 輸血後鉄過剰症の治療. 血液診療エキスパート「貧血」2010

    • Author(s)
      鈴木隆浩
    • Total Pages
      239-242
    • Publisher
      中外医学社

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Published: 2014-08-29  

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