Clarification of RCAN1-mediated deregulation of cellular functionsin leukemia cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591048
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Jichi Medical University
• Principal Investigator: NAGAI Tadashi 自治医科大学, 医学部, 准教授 (40237483)
• Co-Investigator(Renkei-kenkyūsha): OHMINE Ken 自治医科大学, 医学部, 講師 (90316521) ; FUJIWARA Shin-ichiro 自治医科大学, 医学部, 講師 (20438667)
• Project Period (FY): 2010 – 2012
• Keywords: RCAN1 / 急性骨髄性白血病 / HL60 / calcineurin / NFAT

Research Abstract

RCAN1 is involved in the regulation of cell functions including inhibition ofcalcineurin. In this study, we found that RCAN1 is extraordinarily expressed in leukemia cells.Furthermore, we revealed that RCAN1 is important for cell growth, particularly unde

Research Products

• [Journal Article] Rituximab plus 70%cyclophosphamide, doxorubicin, vincristineand prednisone for Japanese patients withdiffuse large B-cell lymphoma aged 70 yearsand older. (2012)
  • Author(s): Meguro, A., Nagai, T., Ozawa, K.
  • Journal Title: Leuk Lymphoma. Volume: 53 Pages: 43-49
  • DOI: DOI:10.3109/10428194.
  • Peer Reviewed
• [Journal Article] Prediction of progression fromrefractory cytopenia with unilineagedysplasia by analysis of bone marrow blastcell composition. (2012)
  • Author(s): Oka, S., Nagai, T., Hanafusa, T.
  • Journal Title: J Clin. Exp. Hematop. Volume: 52 Pages: 63-66
  • DOI: DOI:http://dx.doi.org/10.3960/jslrt.52.6
  • Peer Reviewed
• [Journal Article] Rituximab-induced interstitial pneumonia dueto CD8-positive T-cell infiltration (2012)
  • Author(s): Sato, K., Nagai, T., Izumi, T., Ohmine, K.,Ozaki, K., Muroi, K., and Ozawa, K.
  • Journal Title: ActaHaematologica Volume: 128 Pages: 107-109
  • DOI: DOI:10.1159/000338259.
  • Peer Reviewed
• [Journal Article] Autologous hematopoietic recoverywith aberrant antigen expression afterallogeneic bone marrow transplantation. (2012)
  • Author(s): Kobayashi, H., Nagai, T., Muroi, K.
  • Journal Title: JClin. Exp. Hematop. Volume: 52 Pages: 81-83
  • DOI: DOI:http://dx.doi.org/10.3960/jslrt.52.81
  • Peer Reviewed
• [Journal Article] Alteration of chromosome 13 abnormalitiesafter therapeutic heamatopoiesis recovery inmyelodysplastic syndrome (2012)
  • Author(s): Nagai, T., Suzuki, T., Komatsu, N.,Hosokawa, K., Nakao, S., and Ozawa, K.
  • Journal Title: Open J Hematol. Pages: 3-7
  • DOI: DOI:10.13055/ojhmt_3_1_7.121227
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• [Journal Article] Vincristine potentiates the anti-proliferativeeffect of an aurora kinase inhibitor, VE-465,in myeloid leukemia cells. (2011)
  • Author(s): Yoshida, K., Nagai, T., Ohmine, K., Uesawa,M., Sripayap, P., Ishida, Y., and Ozawa, K.
  • Journal Title: Biochem.Pharmcol. Volume: 82 Pages: 1884-1890
  • DOI: DOI:10.1016/j.bcp.
  • Peer Reviewed
• [Journal Article] Reciprocal upregulationof Notch signaling molecules inhematopoietic progenitor and mesenchymalstromal cells. (2011)
  • Author(s): Kikuchi, Y., Kume, A., Urabe, M.,Mizukami, H., Suzuki, T., Ozaki, K., Nagai,T., and Ozawa, K.
  • Journal Title: J Stem Cells Regenerative Med Volume: 7 Pages: 61-68
  • URL: http://www.pubstemcell.com/monthly/007020300010.htm
  • Peer Reviewed
• [Journal Article] Combination of tipifarnib and rapamycinsynergistically inhibits the growth ofleukemia cells and overcomes resistance totipifarnib via alteration of cellular signalingpathways. (2010)
  • Author(s): Nagai, T., Ohmine, K., Fujiwara, S., Uesawa,M., Sakurai, C., and Ozawa, K.
  • Journal Title: Leukemia Res. Volume: 34 Pages: 1057-1063
  • DOI: DOI:10.1016/j.leukres.
  • Peer Reviewed
• [Journal Article] Imatinib for Newly DiagnosedChronic-Phase Chronic Myeloid Leukemia:Results of a Prospective Study in Japan (2010)
  • Author(s): Nagai, T., Takeuchi, J., Usui, N.
  • Journal Title: Int Jhematol Volume: 92 Pages: 111-117
  • DOI: DOI:10.1007/s12185-010-0621-x.
  • Peer Reviewed
• [Journal Article] AA amyloidosis associated withmacroglobulinemia (2010)
  • Author(s): Tatara, R., Nagai, T., Kobayashi, H., Hatano,K., Suzuki, T., Muroi, K., and Ozawa, K
  • Journal Title: (Letter) Int J Hematol Volume: 92 Pages: 675-677
  • DOI: DOI:10.1007/s12185-010-0700-z
  • Peer Reviewed
• [Journal Article] Incidental carcinomasdetected by PET/CT scans in patients withmalignant lymphoma. (2010)
  • Author(s): Sato, K., Ozaki, K., Matsuyama, T., Ohmine,K., Suzuki, T., Mori, M., Nagai, T., Muroi,K., and Ozawa, K.:
  • Journal Title: Int J Hematol Volume: 92 Pages: 647-650
  • DOI: DOI:10.1007/s12185-010-0702-x.
  • Peer Reviewed
• [Presentation] Histone deacetylase inhibitorromidepsin overcomes AZA-resistance inAZA-resistant cell lines. (2012)
  • Author(s): Sripayap, P.
  • Organizer: The 3rdJSHInternational Symposium
  • Place of Presentation: Kawagoe, Japan
  • Year and Date: 20120000
• [Presentation] Overcoming resistance to5-azacytidine in acute myeloid leukemia (2012)
  • Author(s): Sripayap, P.
  • Organizer: The 54th Annual Meeting of AmericanSociety for Hematology
  • Place of Presentation: Atlanta, USA
  • Year and Date: 20120000
• [Presentation] Analysis of primary smallintestinal lymphoma diagnosed withdouble-balloon endoscopy (2012)
  • Author(s): Kobayashi, H.
  • Organizer: 第74回日本血液学会学術集会
  • Year and Date: 20120000
• [Presentation] Histone deacetylase inhibitorromidepsin overcomes 5-azacytidine (AZA)resistance. (2012)
  • Author(s): Sripayap, P.
  • Organizer: 第74回日本血液学会学術集会
  • Year and Date: 20120000
• [Presentation] Cloning of5-azacitidine-resistant acute myeloidleukemia cell lines, THP-1/AR andHL60/AR. (2011)
  • Author(s): Uesawa, M
  • Organizer: The 2ndJSH InternationalSymposium
  • Place of Presentation: Nagasaki
  • Year and Date: 20110000
• [Presentation] Cloning and characterizationof 5-azacitidine-resistant human AML celllines, THP-1/AR and HL60/A. (2011)
  • Author(s): Sripayap, P
  • Organizer: 第73回日本血液学会学術集会
  • Year and Date: 20110000
• [Presentation] Extraordinary expression ofRCAN1 - Crucial to leukemia progression. (2010)
  • Author(s): Fujiwara, S.
  • Organizer: 第72回日本血液学会学術集会
  • Year and Date: 20100000
• [Presentation] Crucial role of RCAN1 inleukemia progression (2010)
  • Author(s): Fujiwara, S
  • Organizer: 第69回日本癌学会学術総会
  • Year and Date: 20100000