2012 Fiscal Year Final Research Report
Investigation for molecular mechanisms underlying the establishment of "pre"-leukemic stem cells aiming for therapy and prevention of leukemia
| Project/Area Number |
22591054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
TSUZUKI Shinobu 愛知県がんセンター(研究所), 遺伝子医療研究部, 室長 (00342965)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 前白血病 / 白血病性幹細胞 |
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| Research Abstract |
"Pre"-leukemic stage is crucial for the establishment of leukemia. Elucidation of mechanisms underlying the pre-leukemic stage would pave the way to the development of therapy and preventive measures of leukemia. We have successfully modeled "pre"-leukemic stage of TEL-AML1 leukemia in mice, and thus identified 4 genes essential for the establishment of "pre"-leukemic cells. The 4 genes are also essential for the maintenance of leukemia, providing the rationale for strategy of targeting the genes for therapy and prevention of leukemia.
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