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2012 Fiscal Year Final Research Report

Expansion of activated NK cells from cord bloood

Research Project

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Project/Area Number 22591056
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionHokkaido University

Principal Investigator

TANAKA Junji  北海道大学, 大学院・医学研究科, 准教 (50250452)

Project Period (FY) 2010 – 2012
KeywordsNK細胞 / 臍帯血
Research Abstract

We can expand NK cells more than 1,000 fold from cord blood after 3 weeks culture. These expanded NK cells can attack not only K562 leukemic cell line but also patients’ leukemic cells.

  • Research Products

    (31 results)

All 2013 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (18 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Changes in incidence and caus es of non-relapse mortality after al logeneic hematopoietic cell transpla ntation in patients with acute leuke mia/myelodysplastic syndrome2013

    • Author(s)
      Kurosawa S, Tanaka J et al.
    • Journal Title

      Bone M arrow Transplant

      Volume: 48(4) Pages: 529-536

    • Peer Reviewed
  • [Journal Article] Allogeneic hematopoietic stem cell transplantation for intermedia te cytogenetic risk acute myeloid le ukemia in first complete remission.2013

    • Author(s)
      Imahashi N, Tanaka J et al.
    • Journal Title

      Bone Marrow Transplant

      Volume: 48(1) Pages: 56-62

    • Peer Reviewed
  • [Journal Article] Unrelated cord blood transplanta tion vs. related transplantation with HLA 1-antigen mismatch in the gr aft-versus-host direction.2013

    • Author(s)
      Kanda J, Tanaka J et al.
    • Journal Title

      Leukemia

      Volume: 27(2) Pages: 286-294

    • Peer Reviewed
  • [Journal Article] Dasati nib enhances the expansion of CD56+C D3- NK cells from cord blood2012

    • Author(s)
      Tanaka J et al.
    • Journal Title

      Blood1

      Volume: 19 Pages: 6175-6176

    • Peer Reviewed
  • [Journal Article] Expan sion of NK cells from cord blood wit h antileukemic activity using GMP-co mpliant substances without feeder cells2012

    • Author(s)
      Tanaka J et al.
    • Journal Title

      Leukemia

      Volume: 26 Pages: 1149-1152

    • Peer Reviewed
  • [Journal Article] Related transplantation with HLA1-antigen mismatch in the graft-vers us-host direction and HLA 8/8-allele-matched unrelated transplantation:A nationwide retrospective study2012

    • Author(s)
      Kanda J, Tanaka J et al.
    • Journal Title

      Blood

      Volume: 119 Pages: 2409-2416

    • Peer Reviewed
  • [Journal Article] Efficacy of folinic acid in p reventing oral mucositis in allogene ic hematopoietic stem cell transplan t patients receiving MTX as prophylaxis for GVHD2012

    • Author(s)
      Sugita J, Tanaka J et al.
    • Journal Title

      Bone Marrow Transpla nt

      Volume: 47 Pages: 258-264

    • Peer Reviewed
  • [Journal Article] Expansion of CD4+ CD25+ regul atory T cells from cord blood CD4+ cells-chain c ytokines (IL-2 and IL-15) and rapa mycin.2011

    • Author(s)
      Asanuma S, Tanaka J et al.
    • Journal Title

      Ann Hematol

      Volume: 90 Pages: 617-624

    • Peer Reviewed
  • [Journal Article] ZAPS is a potent stimulato r of signaling mediated by the RNA helicase RIG-I during antiviral r esponses2011

    • Author(s)
      Hayakawa S, Tanaka J et al.
    • Journal Title

      Nature Immunol

      Volume: 12 Pages: 37-44

    • Peer Reviewed
  • [Journal Article] p53 transactivation is inv olved in the antiproliferative act ivity of the putative tumor suppre ssor RBM52011

    • Author(s)
      Kobayashi T, Tanaka J et al.
    • Journal Title

      Int J Cancer

      Volume: 128 Pages: 304-318

    • Peer Reviewed
  • [Journal Article] Disease stage stratified ef fects of cell dose in unrelated bo ne marrow transplantation for hema tological malignancies: A report f rom Japan Marrow Donor Program.2011

    • Author(s)
      Inamoto Y, Tanaka J et al.
    • Journal Title

      Bo ne Marrow Transaplant

      Volume: 46 Pages: 1192-1202

    • Peer Reviewed
  • [Journal Article] The 8p11 myeloproliferativ e syndrome due to rare FGFR1OP2-FG FR1 fusion2011

    • Author(s)
      Onozawa M, Tanaka J et al.
    • Journal Title

      Eur J Haematol

      Volume: 86 Pages: 347-349

    • Peer Reviewed
  • [Presentation] Reduced-Intensity Versus Myeloablative Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Patients Aged Over 45 Years with AcuteLymphoblastic Leukemia (ALL) in Remission: A Study From the ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT)2012

    • Author(s)
      Tanaka J, Kanamori H, Nishiwaki S, Ohashi K, Taniguchi S, Eto T, Nakamae H, Katayama Y, Morishima Y, Suzuki R, Kato K, Sakamaki H, Nishimoto N, Masauzi N
    • Organizer
      54th Annual Meeting of American Society of Hematology (ASH)
    • Place of Presentation
      Atlanta, Georgia WorldCongress Center (USA)
    • Year and Date
      20121208-11
  • [Presentation] Unfavorable Outcome of Single-Unit Umbilical Cord Blood Transplantation for Elderly Patients with Myelodysplastic Syndromes.2012

    • Author(s)
      Aoki K, Ishiyama K, Itonaga H, Fukuda T, Taniguchi S, Ueda Y, Doki N, Sugio Y, Morishima Y, Nagamura T, Tanaka J, Atsuta Y, Ishikawa T, Miyazaki Y.
    • Organizer
      54th Annual Meeting of American Society of Hematology (ASH)
    • Place of Presentation
      Atlanta, Georgia World Congress Center (USA)
    • Year and Date
      20121208-11
  • [Presentation] Role of Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia in an HTLV-1Non-Endemic Area of Japan.2012

    • Author(s)
      Shigematsu A, Tanaka J, Kobayashi N, Yasui H, Shindo M, Kakinoki Y, Iyama S, Kuroda H, Tsutsumi Y, Hashino S, Imamura M, Teshima T.
    • Organizer
      54th Annual Meeting of American Society of Hematology (ASH)
    • Place of Presentation
      Atlanta, Georgia World Congress Center (USA)
    • Year and Date
      20121208-11
  • [Presentation] Favorable Outcomes of Autologous Stem Cell Transplantation in Adult Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Remission: On Behalf of the Adult Acute Lymphoblastic Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT).2012

    • Author(s)
      Kato H, Kawase T, Kako S, Mizuta S, Ohashi K, Kurokawa M, Iwato K, Mori T, Suzuki R, Sakamaki H, Morishima Y, Tanaka J.
    • Organizer
      54th Annual Meeting of American Society of Hematology (ASH)
    • Place of Presentation
      Atlanta, Georgia World Congress Center (USA)
    • Year and Date
      20121208-11
  • [Presentation] Impact of ParentalDonor Type On Outcomes AfterHLA-Matched and HLA-MismatchedT-Cell-Replete Hematopoietic Cell Transplantation for Patients with Leukemia: A Retrospective Cohort Study.2012

    • Author(s)
      Ichinohe T, Kanda J, Inagaki J, Inoue M, Koh K, Kikuta A, Yabe H, Tanaka J, Atsuta Y, Kanda Y.
    • Organizer
      54th Annual Meeting of American Society of Hematology (ASH)
    • Place of Presentation
      Atlanta, GeorgiaWorld Congress Center (USA)
    • Year and Date
      20121208-11
  • [Presentation] The effect of dasatinib on the expansion of CD56+CD3- NK cells from cord blood2012

    • Author(s)
      Tanaka J, Sugita J, Shiratori S, Shigematsu A, Imamura M
    • Organizer
      41st Annual Meeting of InternationalSociety of Hematology (ISEH)
    • Place of Presentation
      Amsterdam, Hotel Okura(Netherlands)
    • Year and Date
      20120823-26
  • [Presentation] 抗腫瘍効果におけるNK細胞の役割2012

    • Author(s)
      田中淳司
    • Organizer
      第78回青森血液疾患セミナー
    • Place of Presentation
      青森、ホテル青森(青森県)
    • Year and Date
      2012-09-19
  • [Presentation]2012

    • Author(s)
      田中淳司
    • Organizer
      血液がんの治療つばさ共催フォーラム
    • Place of Presentation
      札幌、北海道大学クラーク会館(北海道)
    • Year and Date
      2012-09-01
  • [Presentation] 成人ALLの移植療法について2012

    • Author(s)
      田中淳司
    • Organizer
      第7回TokaiLeukemiaClub
    • Place of Presentation
      名古屋、ミッドスクエア(愛知県)
    • Year and Date
      2012-03-03
  • [Presentation] 抗腫瘍効果におけるNK細胞の役割2012

    • Author(s)
      田中淳司
    • Organizer
      函館血液疾患セミナー
    • Place of Presentation
      函館、ホテル函 館(北海道)
    • Year and Date
      2012-02-22
  • [Presentation] Fludarabine-Based Reduced Intensity Hematopoietic Stem Cell Transplantation (RIST) for Patients Aged 50-70 Years with Acute Lymphoblastic Leukemia (ALL) in Remission: A Study From the ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT).2011

    • Author(s)
      Kanamori H, Kako S, Kato H, Nishiwaki S, Furukawa T, Saito M, Taniguchi S, Nakamae H, Yujiri T, Naganuma-Inoue T, Morishima Y, Suzuki R, Sakamaki H, Tanaka J.
    • Organizer
      53rdAnnual Meeting of American Society of Hematology (ASH)
    • Place of Presentation
      San Diego, San Diego Convention Center(USA)
    • Year and Date
      20111210-13
  • [Presentation] Prognostic Factors of Reducing Relapse in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation From Related Donor for Acute Myeloid Leukemia: The Japan Society for Hematopoietic Cell Transplantation (JSHCT) AML Working Group.2011

    • Author(s)
      Yano Y, Yokoyama H, Nishimura R, Fukuda T, Ogawa H, Ohashi K, Kanamori H, Tanaka J, Sakamaki H, Atsuta Y, Takami A.
    • Organizer
      53rd Annual Meeting of American Society of Hematology (ASH)
    • Place of Presentation
      San Diego, San Diego ConventionCenter (USA)
    • Year and Date
      20111210-13
  • [Presentation] Chemorefractory Disease At Transplantation, and Umbilical Cord Blood As Donor Source Were Adverse Prognostic Factors for Overall Survival After Allogeneic Stem Cell Transplantation for Follicular Lymphoma: Retrospective Study of the Japan Society of Hematopoietic Stem Cell Transplantation (JSHCT) Lymphoma Working Group2011

    • Author(s)
      Izutsu K, Suzuki R, Kako S, Sakai R, Mori T, Yano S, Kato J, Fukuda T, Taniguchi S, Takanashi M, Morishima Y, Tanaka J, Suzumiya J. Poor Performance Status
    • Organizer
      53rd Annual Meeting of American Society of Hematology (ASH)
    • Place of Presentation
      San Diego, San DiegoConvention Center (USA)
    • Year and Date
      20111210-13
  • [Presentation] The comparative study for expansion of CD4+CD25+FoxP3+ regulatory T cells from cord blood CD4+ cells using IL-15 or IL-2 with rapamycin.2011

    • Author(s)
      Tanaka J, Sugita J, Asanuma S, Shiratori S, Shigematu1 A, Fujimoto K, Nishio M, Kondo T, Imamura M.
    • Organizer
      40th Annual Meeting of International Society of Hematology (ISEH)
    • Place of Presentation
      Vancouver, Westin Bayshore Hotel (Canada)
    • Year and Date
      20110825-28
  • [Presentation] GVHD/GVL制御とNK細胞2011

    • Author(s)
      田中淳司
    • Organizer
      第33回日本造血細胞移植学会総会
    • Place of Presentation
      松山、愛媛県県民文化会館(愛媛県)
    • Year and Date
      20110309-10
  • [Presentation] The Yield of Peripheral Blood (PB) Graft and the Changes of Adhesion Molecules Expression on PB CD34Positive (CD34+) Cells before and during Administration of Granulocyte-colony stimulating factor (G-CSF) American Society for Blood and Marrow Transplantation2011

    • Author(s)
      Masauzi N, Tanaka J, Imamura M.
    • Place of Presentation
      Hawaii, HawaiiConvention Center (USA)
    • Year and Date
      20110217-21
  • [Presentation] Retrospective analysis for 272 patients with mature T-cell neoplasmas in Hokkaido, Japan2010

    • Author(s)
      Shigematsu A, Kobayashi N, Minauchi K, Kobayashi H, Mori A, Masauzi N, Umehara S, Fukuhara T, Kurosawa M, Haseyama M, Hashino S, Nishio M, Kondo T, Tanaka J, Kasai M, Imamura M
    • Organizer
      15st Congres of European Hematology Association
    • Place of Presentation
      Barcelona, Barcelona Convention Center (Spain)
    • Year and Date
      20100610-13
  • [Presentation] 造血細胞移植とNK細胞2010

    • Author(s)
      田中淳司
    • Organizer
      第45回愛媛臨床血液懇話会
    • Place of Presentation
      松山、大和屋本店(愛媛県)
    • Year and Date
      2010-08-07
  • [Patent(Industrial Property Rights)] NK細胞を増幅するための組成物及び方法2011

    • Inventor(s)
      田中淳司
    • Industrial Property Rights Holder
      テラ株式会社
    • Industrial Property Number
      特願 2011-140504
    • Filing Date
      2011-06-24

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Published: 2014-08-29  

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