Hypogammaglobulinemia after rituximab administration and phenotypic change of B lymphocytes

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Hokkaido University
• Principal Investigator: NISHIO Mitsusumi 北海道大学, 大学院・医学研究科, 非常勤講師 (10322801)
• Project Period (FY): 2010 – 2012
• Keywords: rituximab / 低免疫グロブリン血症

Research Abstract

We investigated the serum IgG levels in a total 16 of non-treated non-Hodgkin lymphoma before and after R-CHOP therapy. When hypogammaglobulinemia is defined as the levels lower than 800 mg/dl, 11 patients developed hypogammaglobulinemia after median 3 months of R-CHOP. However, the delayed recovery of surface CD20/CD27 positive and IgD negative cells were not seen in the patients who had hypogammglobulinemia. Hypogammaglobulinemia with abnormal B cell recovery is specific for the case underwent stem cell transplantation plus rituximab.

Research Products

• [Journal Article] Epidemiology and treatment outcome of invasive fungal infections in patients with hematologicalmalignancies (2012)
  • Author(s): Kurosawa M, Yonezumi M, Hashino S, Tanaka J, Nishio M, Kaneda M, Ota S, Koda K, Suzuki N, Yoshida M, Hirayama Y, Takimoto R, Torimoto Y,Mori A, Takahashi T, Iizuka S, Ishida T, Kobayashi R, Oda T, Sakai H, Yamamoto S, Takahashi F, Fukuhara T
  • Journal Title: Int J Hematol Volume: 96(6) Pages: 748-57
  • DOI: doi:10.1007/s12185-012-1210-y
  • Peer Reviewed
• [Journal Article] A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens (2012)
  • Author(s): Kashiwazaki H, Matsushita T, Sugita J, Shigematsu A, Kasashi K, Yamazaki Y, Kanehira T, Kondo T, Endo T, Tanaka J, Hashino S, Nishio M, Imamura M,Kitagawa Y, Inoue N.
  • Journal Title: Support Care Cancer Volume: 20(5) Pages: 933-9
  • DOI: doi:10.1007/s00520-011-1164-2
  • Peer Reviewed
• [Journal Article] Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis forGVHD (2012)
  • Author(s): Sugita J, Matsushita T, Kashiwazaki H, Kosugi M, Takahashi S, Wakasa K, Shiratori S, Ibata M, Shono Y, Shigematsu A, Obara M, Fujimoto K, Endo T, Nishio M, Kondo T, Hashino S, Tanaka J, Asaka M,Imamura M
  • Journal Title: Bone Marrow Transplant Volume: 47(2) Pages: 258-64
  • DOI: doi:10.1038/bmt.2011.53
  • Peer Reviewed
• [Journal Article] Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrowtransplantation (2012)
  • Author(s): Kashiwazaki H, Matsushita T, Sugita J, Shigematsu A, Kasashi K, Yamazaki Y, Kanehira T, Yamamoto S, Kondo T, Endo T,Tanaka J, Hashino S, Nishio M, Imamura M, Kitagawa Y, Inoue N
  • Journal Title: Support Care Cancer Volume: 20(2) Pages: 367-73
  • DOI: doi:10.1007/s00520-011-1116-x
  • Peer Reviewed
• [Presentation] The absolute number of lymphocyte/monocyte do not predict survival of patients in DLBCL after PBSCT (2012)
  • Author(s): Nishio M
  • Organizer: 日本血液学会総会
  • Place of Presentation: 京都国際会議場(京都市)
  • Year and Date: 20121019-20121021