2012 Fiscal Year Final Research Report
Development of novel therapy for thrombotic microangiopathy after hematopoietic stem cell transplantation.
| Project/Area Number |
22591069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMURA Yoshihiro (80118033)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 造血幹細胞移植学 |
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| Research Abstract |
The pathogenesis and optimal treatment of thrombotic microangiopathy (TMA) associated with stem cell transplantation (SCT) have not been established. We analyzed 3 patients with SCT-TMA from before SCT in detail and found increased plasma levels of von Willebrand factor (VWF) antigen without a deficiency of ADAMTS13 activity. VWF multimers analysis showed the existence of unusually large VWF multimers before TMA development and the defect of high molecular weight multimers during TMA bouts. Recombinant thrombomodulin might improve the efficacy of platelet transfusion in patients with SCT-TMA.
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[Journal Article] Ticlopidine -associated ADAMTS13 activity deficient thrombotic thrombo- cytopenic purpura in 22 persons in Japan: A Report from the Southern Network on Adverse Reactions (SONAR)2013
Author(s)
Bennett CL, Jacob S, Dunn BL, Georgantopoulos P, Zheng XL, Kwaan HC, McKoy JM, Magwood JS, Bandarenko N, Winters JL, Raife TJ, Carey PM, Sarode R, Kiss JE, Danielson C, Ortel TL, Clark WF, Ablin R, Rock G, Matsumoto M, Fujimura Y
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Journal Title
Br J Haematol
Volume: (in press)
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[Journal Article] Analysis of genetic and predisposing factors in Japanese patients with atypical hemolytic uremic syndrome2013
Author(s)
Fan X, Yoshida Y, Honda S, Matsumoto M, Sawada Y, Hattori M, Hisanaga S, Hiwa R, Nakamura F, Tomomori M, Miyagawa S, Fujimaru R, Yamada H, Sawai T, Ikeda Y, Iwata N, Uemura O, Matsukuma E, Aizawa Y, Harada H, Wada H, Ishikawa E, Ashida A, Nangaku M, Miyata T, Fujimura Y
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Journal Title
Mol Immunol
Volume: 54
Pages: 238-246
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[Journal Article] Drug-induced thrombotic thrombocytopenic purpura success- fully treated with recombinant human soluble thrombomodulin2013
Author(s)
Nishijima Y, Hirata H, Himeno A, Kida H, Matsumoto M, Takahashi R, Otani Y, Inoue K, Nagatomo I, Takeda Y, Kijima T, Tachibana I, Fujimura Y, Kumanogoh A
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Journal Title
Inter Med
Volume: 52
Pages: 1111-1114
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[Journal Article] ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score2012
Author(s)
Takaya H, Uemura M, Fujimura Y, Matsumoto M, Matsuyama T, Kato S, Morioka C, Ishizashi H, Hori Y, Fujimoto M, Tsujimoto T, Kawaratani H, Toyohara M, Kurumatani N, Fukui H
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Journal Title
Hepatol Res
Volume: 42
Pages: 459-72
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[Journal Article] Identification and Recombinant Analysis of Botrocetin-2, a Snake Venom Cofactor for von Willebrand Factor-Induced Platelet Agglutination2012
Author(s)
Yamamoto-Suzuki Y, Sakurai Y, Fujimura Y, Matsumoto M, Hamako J, Kokubo T, Kitagawa H, Kawsar SM, Fujii Y, Ozeki Y, Matsushita F, Matsui T
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Journal Title
Biochemistry
Volume: 51
Pages: 5329-5338
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[Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus2012
Author(s)
Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y
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Journal Title
Atherosclerosis
Volume: 224
Pages: 511-514
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[Journal Article] Two newborn-onset patients of Upshaw-Schulman syndrome with distinct subsequent clinical courses2012
Author(s)
Tanabe S, Yagi H, Kimura T, Isonishi A, Kato S, Yoshida Y, Hayakawa M, Matsumoto M, Ohtaki S, Takahashi Y, Fujimura Y
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Journal Title
Int J Hematol
Volume: 96
Pages: 789-797
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[Journal Article] 胎児治療を行った重症 RhE 不適合妊娠による新生児溶血性疾患の 1例2010
Author(s)
武山雅博,藤田百合,内田賀子,柴田真里,釜本智之,新居育世,井崎和史,西久保敏也,佐道俊幸,赤坂珠理晃,小林浩,西田幸世,松本雅則,藤村吉博,高橋幸博
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Journal Title
日本産婦人科・新生児血液学会誌
Volume: 19
Pages: 51-55
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[Journal Article] 奈良県立医科大学透析部におけるヘパリン起因性血小板減少症(HIT)症例の検討2010
Author(s)
小西康司,吉田克法,多山幸,切畑屋智史,岩下裕一,横田基次,萱島道徳,米田龍生,石西綾美, 松本雅則, 藤村吉博
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Journal Title
奈透析会誌
Volume: 15
Pages: 59-63
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