2012 Fiscal Year Final Research Report
Investigation of integrin inside-out signaling using RIAM deficientplatelets.
| Project/Area Number |
22591070
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 血栓止血 / 血小板 / インテグリン / RIAM |
|---|
| Research Abstract |
To investigate the molecular mechanism of platelet function, wegenerated platelet specific RIAM-deficient mice. However, the fibrinogen binding was notcompletely inhibited by RIAM deletion, the RIAM-deficient platelets showed impairedfibrinogen binding in
|
