2012 Fiscal Year Final Research Report
Identification of novel citrullinated antigen of RA, prospects for the pathogenesis of rheumamtoid arthritis and biomarkers
| Project/Area Number |
22591086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Haeru 東京医科大学, 医学部, 助教 (90424415)
HASHIMOTO Shiori 東京女子医科大学, 医学部, 准教授 (60180824)
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| Project Period (FY) |
2010 – 2012
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| Keywords | リウマチ学 / 関節リウマチ / シトルリン化ペプチド / 自己抗原 / 自己抗体 |
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| Research Abstract |
Although anti-citrullinated peptide (ACPA) is specific for rheumatoid arthritis (RA), the pathogenic citrullinated autoantigen relevant for RA remains to be elucidated. In the present study, we have demonstrated the specific presence of citrullinated cellular fibronectin in RA synovial fluids, which could be involved in the pathogenesis of RA thorough formation of immune complexes within the affected joints. Additionally, we demonstrated the correlation of anti-MCV (mutated citrullinated vimentin) antibody with the number of tender/swollen joints, suggesting that anti-MCV antibody might be useful for monitoring RA disease activity.
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