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2012 Fiscal Year Final Research Report

Identification of novel citrullinated antigen of RA, prospects for the pathogenesis of rheumamtoid arthritis and biomarkers

Research Project

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Project/Area Number 22591086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionTokyo Medical University

Principal Investigator

SAWADA Tetsuji  東京医科大学, 医学部, 准教授 (50235470)

Co-Investigator(Renkei-kenkyūsha) HAYASHI Haeru  東京医科大学, 医学部, 助教 (90424415)
HASHIMOTO Shiori  東京女子医科大学, 医学部, 准教授 (60180824)
Project Period (FY) 2010 – 2012
Keywordsリウマチ学 / 関節リウマチ / シトルリン化ペプチド / 自己抗原 / 自己抗体
Research Abstract

Although anti-citrullinated peptide (ACPA) is specific for rheumatoid arthritis (RA), the pathogenic citrullinated autoantigen relevant for RA remains to be elucidated. In the present study, we have demonstrated the specific presence of citrullinated cellular fibronectin in RA synovial fluids, which could be involved in the pathogenesis of RA thorough formation of immune complexes within the affected joints. Additionally, we demonstrated the correlation of anti-MCV (mutated citrullinated vimentin) antibody with the number of tender/swollen joints, suggesting that anti-MCV antibody might be useful for monitoring RA disease activity.

  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results) Book (3 results)

  • [Journal Article] Detection of autoantibody to citrullinated BiP in rheumatoid arthritis patients and proinflammatory roles of citrullinated BiP in collagen-induced arthritis2011

    • Author(s)
      Shoda H, Fujio K, Shibuya M, Okamura T, Sumitomo S, Okamoto A, Sawada T, Yamamoto K
    • Journal Title

      Arthritis Res Ther

      Volume: 13(6) Pages: R191

    • DOI

      doi:10.1186/ar3520

    • Peer Reviewed
  • [Journal Article] Severe headache complicated by vertical atlantoaxial subluxation in diffuse systemic sclerosis with crowned dens pattern calcification.2011

    • Author(s)
      Shoji A, Tahara K, Hayashi H, Tsuji S, Kimura E, Yamamoto K, Odawara M, Sawada T
    • Journal Title

      Rheumatol Int

      Volume: 31(9) Pages: 1247-50

    • DOI

      doi:10.1007/s00296-010-1703-z

    • Peer Reviewed
  • [Presentation] 関節リウマチ関節液中のシトルリン化 Cellular Fibronectin の同定2013

    • Author(s)
      木村英里、神崎健仁、関 雅之、庄司亜樹、森 浩章、 林 映、大塚麻由、太原恒一郎、山本一彦、沢田哲治
    • Organizer
      第57回日本リウマチ学会総会・学術集会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2013-04-18
  • [Book] 抗 CCP抗体による治療反応性および関節予後の予測 リウマチ科 47(6)2012

    • Author(s)
      大塚麻由、沢田哲治、橋本しをり
    • Total Pages
      587-593
    • Publisher
      科学評論社
  • [Book] 関節リウマチにおけるシトルリン化抗原と歯周病リウマチ科46(3)2011

    • Author(s)
      關雅之、大塚麻由、沢田哲治、橋本しをり
    • Total Pages
      282-287
    • Publisher
      科学評論社
  • [Book] 早期診断のためにどの血液学的マーカーを測定し活用するか Bone Joint Nerve 1(1)2011

    • Author(s)
      沢田哲治
    • Total Pages
      10-15
    • Publisher
      アークメディア社

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Published: 2014-08-29  

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