2012 Fiscal Year Final Research Report
Study of novel factor, SPACIA1 which is expressed in synovial tissue in rheumatoid arthritis.
| Project/Area Number |
22591088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
FUJII Ryoji 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 (10333535)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Tomoo 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 (30387063)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANO Yoshihisa 聖マリアンナ医科大学, 医学(系)研究科(研究院), 准教授 (80445882)
SATO Tomoo 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 (30387063)
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| Research Collaborator |
KOMATSU Rie 聖マリアンナ医科大学, 医学(系)研究科(研究院), 研究技術員 (80517475)
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| Project Period (FY) |
2010 – 2012
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| Keywords | リウマチ学 |
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| Research Abstract |
Recently we identified a novel factor SPACIA1 associated with synovitis. In this study we identified a core promoter of SPACIA1 gene. We have been trying purification and identification of transcriptional factor that bound the core promoter. We also discovered that SPACIA1 related a G1 phase-cell cycle factor (CDK6) gene expression. Using SPACIA1 transgenic mouse, we showed SPACIA1 is a disease-modifying, but not causal, factor.
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[Journal Article] Analysis of a Core Promoter Context of Synoviocyte Proliferation- Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis.2012
Author(s)
Fujii R, Komatsu R, Sato T, Yagishita N, Aratani S, Araya N, Nishikawa H, Yamano Y, Yudoh K,Beppu M, Nishioka K, Nakajima T
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Journal Title
J St. Marianna Univ.
Volume: 40(2)
Pages: 51-56
Peer Reviewed
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[Journal Article] a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans.2011
Author(s)
Sato T, Fujii R, Konomi K, Yagishita N, Aratani S, Araya N, Aono H, Yudoh K, Suzuki N, Beppu M, Yamano Y, Nishioka K, Nakajima T. Overexpression of SPACIA1/SAAL1
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Journal Title
Arthritis Rheum
Volume: 63(12)
Pages: 3833-42
DOI
Peer Reviewed
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