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2013 Fiscal Year Final Research Report

Mechanism and therapy of neutrophilic allergic airway inflammation in severe asthma

Research Project

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Project/Area Number 22591092
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionOkayama University

Principal Investigator

KANEHIRO ARIHIKO  岡山大学, 医歯(薬)学総合研究科, 准教授 (20243503)

Co-Investigator(Kenkyū-buntansha) MIYAHARA Nobuaki  岡山大学, 大学病院, 講師 (70335610)
Project Period (FY) 2010-04-01 – 2014-03-31
Keywords重症喘息 / アレルギー / 好中球性炎症 / 気道炎症 / 好中球エラスターゼ / 好中球エラスターゼ阻害薬 / ロイコトリエン受容体拮抗薬 / IL-17
Research Abstract

Severe asthma is often associated with neutrophilic allergic inflammation in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-induced airway responses is not well defined. We have investigated the impact of neutrophil elastase inhibition on the development of allergic airway inflammation and airway hyperresponsiveness (AHR) in previously sensitized and challenged mice. We indicate that neutrophil elastase plays an important role in the development of the neutrophilic and eosinophilic airway inflammation and hyperresponsiveness.
Furthermore, we demonstrate that treatment with cysteinyl leukotriene receptor antagonist significantly suppressed the AHR, static compliance, and eosinophilic and neutrophilic airway inflammation in OVA sensitization and challenge asthma model with porcine pancreatic elastase (PPE) instillation.

  • Research Products

    (34 results)

All 2014 2013 2012 2011 2010

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (7 results) Book (3 results)

  • [Journal Article] Effect of a Cysteinyl Leukotriene Receptor Antagonist on Experimental Emphysema and Asthma Combined with Emphysema2014

    • Author(s)
      Ikeda G, Kanehiro A, et al
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 50 Pages: 18-29

    • DOI

      10.1165/rcmb.2012-0418OC

    • Peer Reviewed
  • [Journal Article] IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice2013

    • Author(s)
      Kurimoto E, Kanehiro A, et al
    • Journal Title

      Respir Res

      Volume: 14 Pages: 5

    • DOI

      10.1186/1465-9921-14-5

    • Peer Reviewed
  • [Journal Article] Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge : neutrophil elastase inhibition attenuates allergic airway responses2013

    • Author(s)
      Koga H, Kanehiro A, et al
    • Journal Title

      Respir Res

      Volume: 14 Pages: 8

    • DOI

      10.1186/1465-9921-14-8

    • Peer Reviewed
  • [Journal Article] Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma2013

    • Author(s)
      Ueno-Iio T, Kanehiro A, et al
    • Journal Title

      Life Sci

      Volume: 92 Pages: 1015-1023

    • DOI

      10.1016/j.lfs.2013.03.022

    • Peer Reviewed
  • [Journal Article] A definite case of (L)-carbocisteine-induced pneumonia with CATCH22 syndrome2013

    • Author(s)
      Kudo K, Miyahara N, et al
    • Journal Title

      Intern Med

      Volume: 52 Pages: 97-100

    • Peer Reviewed
  • [Journal Article] 縱隔リンパ節転移のみで術後再発した腎細胞癌にEBUS-TBNAが有効であった1例2013

    • Author(s)
      後藤田裕子、金廣有彦,他
    • Journal Title

      気管支学

      Volume: 35 Pages: 525-529

    • Peer Reviewed
  • [Journal Article] 大学職員における受動喫煙の認識と尿中コチニン濃度を指標とした受動喫煙に関する調査2013

    • Author(s)
      古賀光、金廣有彦,他
    • Journal Title

      日本呼吸器学会誌

      Volume: 2 Pages: 175-181

    • Peer Reviewed
  • [Journal Article] 呼吸器疾患の診断と治療(II)薬剤誘起性肺炎2013

    • Author(s)
      金廣有彦
    • Journal Title

      医学と薬学

      Volume: 69 Pages: 249-255

    • Peer Reviewed
  • [Journal Article] Evaluation of the usefulness of objective clinical tests for diagnosis of mild asthma in the early stage2012

    • Author(s)
      Sagara H, Kanehiro A, et al
    • Journal Title

      Allergol Immmunol

      Volume: 19 Pages: 1310-1321

    • Peer Reviewed
  • [Journal Article] Survey on the instructions (action plans) prescribed by asthma experts in Japan2012

    • Author(s)
      Kanehiro A, Atsuta R, et al
    • Journal Title

      Allergol Immmunol

      Volume: 19 Pages: 1310-1321

    • Peer Reviewed
  • [Journal Article] Allergic rhinitis and comorbid asthma–Management (Medications)-2012

    • Author(s)
      Kanehiro A
    • Journal Title

      Allergy in Practice

      Volume: 32 Pages: 32-37

    • Peer Reviewed
  • [Journal Article] 客観的検査指標による発症早期の軽症喘息診断治療の有用性の検2012

    • Author(s)
      金廣有彦,他
    • Journal Title

      Allergy and Immunology

      Volume: 19 Pages: 124-135

    • Peer Reviewed
  • [Journal Article] IAA研究会.喘息治療の専門医の治療指示実態調査2012

    • Author(s)
      金廣有彦,他
    • Journal Title

      Allergy and Immunology

      Volume: 19 Pages: 96-106

    • Peer Reviewed
  • [Journal Article] アレルギー性鼻炎と喘息の合併—治療—2012

    • Author(s)
      金廣有彦
    • Journal Title

      アレルギーの臨床

      Volume: 32 Pages: 32-37

    • Peer Reviewed
  • [Journal Article] Churg-Strauss syndrome with necrosis of the toe tips2011

    • Author(s)
      Waseda K, Kanehiro A, et al
    • Journal Title

      Acta Med Okayama

      Volume: 65 Pages: 215-218

    • Peer Reviewed
  • [Journal Article] Blocking the leukotriene B4 receptor1 inhibits late asthmatic responses in establish disease2011

    • Author(s)
      Waseda K, Kanehiro A, et al
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 45 Pages: 851-857

    • DOI

      10.1165/rcmb.2010-0455OC

    • Peer Reviewed
  • [Journal Article] Requirement for CCR5 in the development of allergen-induced airway hyperresponsiveness and inflammation2011

    • Author(s)
      Fuchimoto Y, Kanehiro A, et al
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 45 Pages: 1248-1255

    • DOI

      10.1165/rcmb.2010-0465OC

    • Peer Reviewed
  • [Journal Article] Successful Extracorporeal Life Support for Life-threatening Hypercapnia with Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation2011

    • Author(s)
      Waseda K, Kanehiro A, et al
    • Journal Title

      Acta Med Okayama

      Volume: 65 Pages: 403-406

    • Peer Reviewed
  • [Journal Article] Measurement of early-phase, late-phase, and nonspecific nasal responses in allergic rhinitis mouse by whole body plethysmography2011

    • Author(s)
      Miyahara S, Miyahara N, et al
    • Journal Title

      Nihon Yakurigaku Zasshi

      Volume: 137 Pages: 141-145

    • Peer Reviewed
  • [Journal Article] Experimental pulmonary granuloma mimicking sarcoidosis induced by Propionibacterium acnes in mice2010

    • Author(s)
      Iio K, Kanehiro A, et al
    • Journal Title

      Acta Med Okayama

      Volume: 64 Pages: 75-83

    • Peer Reviewed
  • [Journal Article] Interstitial lung disease during trimethoprim/sulfamethoxazole administration2010

    • Author(s)
      Yuzurio S, et al
    • Journal Title

      Acta Med Okayama

      Volume: 64 Pages: 181-187

    • Peer Reviewed
  • [Journal Article] Effects of combination therapy with montelukast and carbocysteine in allergen-induced airway hyperresponsiveness and airway inflammation2010

    • Author(s)
      Takeda K, Miyahara N, et al
    • Journal Title

      Br J Pharmacol

      Volume: 160 Pages: 1399-407

    • DOI

      10.1111/j.1476-5381.2010.00797.x

    • Peer Reviewed
  • [Journal Article] Plasticity of invariant NKT cell regulation of allergic airway disease is dependent on IFN-gamma production2010

    • Author(s)
      Matsuda H, Miyahara N, et al
    • Journal Title

      J Immunol

      Volume: 185 Pages: 253-262

    • DOI

      10.4049/jimmunol.0902301

    • Peer Reviewed
  • [Journal Article] Diffuse alveolar hemorrhage with chronic thyroiditis in an advanced-age adult2010

    • Author(s)
      Fujii M, Kanehiro A, et al
    • Journal Title

      Respiratory Medicine CME

      Volume: 3 Pages: 90-92

    • Peer Reviewed
  • [Presentation] The effect of trehalose for the allergen-induced airway hyperresponsiveness and airway inflammation in mice2013

    • Author(s)
      Kurimoro E, Kanehiro A, et al
    • Organizer
      23^<th > European Respiratory Society Annual Congress
    • Place of Presentation
      バルセロナ
    • Year and Date
      20130000
  • [Presentation] Requirement for the receptor for advanced glycation end-products (RAGE) in allergen-induced airway inflammation2013

    • Author(s)
      Taniguchi Y, Kanehiro A, et al
    • Organizer
      108^<th> Annual International Conference of the American Thoracic Society International Conference
    • Place of Presentation
      フィラデルフィア
    • Year and Date
      20130000
  • [Presentation] IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice2013

    • Author(s)
      Kurimoro E, Kanehiro A, et al
    • Organizer
      108^<th> Annual International Conference of the American Thoracic Society International Conference
    • Place of Presentation
      フィラデルフィア
    • Year and Date
      20130000
  • [Presentation] Contrasting roles for the receptor for advanced glycation end-products (RAGE) in allergic airway inflammation versus airway hyperresponsiveness2012

    • Author(s)
      Taniguchi Y, Kanehiro A, et al
    • Organizer
      107^<th> Annual International Conference of the American Thoracic Society International Conference
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      20120000
  • [Presentation] Trehalose alleviates allergen-induced airway hyperresponsiveness in mice2012

    • Author(s)
      Kurimoro E, Kanehiro A, et al
    • Organizer
      107 ^<th> Annual International Conference of the American Thoracic Society International Conference
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      20120000
  • [Presentation] Importance of the receptor for advanced glycation end products (RAGE) to the development of elastase-induced pulmonary inflammation and emphysema in mice2011

    • Author(s)
      Waseda K, Kanehiro A, et al
    • Organizer
      106^<th> Annual International Conference of the American Thoracic Society International Conference
    • Place of Presentation
      デンバー
    • Year and Date
      20110000
  • [Presentation] Effect of Cysteinyl Leukotriene Receptor Antagonist on airway hyperresponsiveness, airway inflammation, and the development of emphysematous change in a murine model of COPD combined with bronchial asthma2010

    • Author(s)
      Ikeda G, Kanehiro A, et al
    • Organizer
      105^<th> Annual International Conference of the American Thoracic Society International Conference
    • Place of Presentation
      サンディエゴ
    • Year and Date
      20100000
  • [Book] 呼吸療法・呼吸管理における5years文献レビュー2009-20132014

    • Author(s)
      金廣有彦, (共著)
    • Total Pages
      240(91-104)
    • Publisher
      克誠出版株式会社, (東京)
  • [Book] アレルギー性肺疾患運動誘発喘息別冊・医学のあゆみ呼吸器疾患ver.6 -state of arts2013

    • Author(s)
      金廣有彦, (共著)
    • Total Pages
      504(230-232)
    • Publisher
      医歯薬出版株式会社, (東京)
  • [Book] 4.喘息死防止に残された課題The 32^<nd> ROKKO CONFERENCE喘息治療に残された課題2013

    • Author(s)
      金廣有彦, (共著)
    • Total Pages
      122(66-71)
    • Publisher
      ライフサイエンス出版株式会社, (東京)

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Published: 2015-07-16  

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