2012 Fiscal Year Final Research Report
Role of galectin-9 and myeloid derived suppressor cells in patients with lung injury
| Project/Area Number |
22591095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Shinichiro 熊本大学, 医学部附属病院, 特任助教 (20419633)
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| Research Collaborator |
MASUNAGA Aiko 熊本大学, 大学院・生命科学研究部, 大学院生
KOJIMA Keisuke 熊本大学, 医学部附属病院, 特任助教 (80467985)
HORIO Yuko 熊本大学, 大学院・生命科学研究部, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肺障害 / ガレクチン 9 / 骨髄由来免疫抑制性細胞 / 樹状細胞 |
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| Research Abstract |
To examine immunomodulating activity of galectin-9, the inducibility of HLA-DRCD33+myeloid derived suppressor cells (MDSCs) and dendritic cells (DC) in peripheral bloodmononuclear cells (PBMC) by galectin-9 were compared between healthy volunteers group(HV group) and patients with lung diseases group (LD group). Culture of PBMC withgalectin-9 exhibited the induction of MDSCs, there was no difference between those groups.In the absence of galectin-9, percentage of cultured plasmacytoid DC (pDC) and myeloidDC (mDC) in patients with sarcoidosis were lower than those in HV group. In the presencewith galectin-9, suppression of pDC induction and enhancement of mDC induction wereobserved in both groups. These findings indicated that galectin-9 induced differentialresponses in subtypes of DC.
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[Journal Article] Favorable outcomewith hemoperfusion of polymyxinB-immobilized fiber column for rapidlyprogressive interstitial pneumoniaassociated with clinically amyopathicdermatomyositis: report of three cases2013
Author(s)
Ichiyasu H, Horio Y, Tsumura S, HirosakoS, Sakamoto Y, Sakata S, Nakashima K,Komatsu T, Kojima K, Masunaga A, FujiiK, Saita N, Kohrogi H
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Journal Title
Peer Reviewed
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[Journal Article] Fibroproliferative changes onhigh-resolution CT in the acuterespiratory distress syndrome predictmortality and ventilator dependency: aprospective observational cohort study2012
Author(s)
Ichikado K, Muranaka H, Gushima Y,Kotani T, Nader HM, Fujimoto K, JohkohT, Iwamoto N, Kawamura K, Nagano J,Fukuda K, Hirata N, Yoshinaga T,Ichiyasu H, Tsumura S, Kohrogi H,Kawaguchi A, Yoshioka M, Sakuma T, SugaM
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Journal Title
BMJ Open
Volume: 2
Pages: e000545
Peer Reviewed
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[Journal Article] リンパ脈管筋腫症 7 例の臨床像と血清 VEGF-C, -Dおよび VEGF-R3 値の相関2012
Author(s)
岡林比呂子, 増永愛子, 一安秀範, 津村真介, 小嶋圭介, 佐伯祥, 濱本淳二, 藤井一彦, 税田直樹, 興梠博次
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Journal Title
日呼吸誌
Volume: 1
Pages: 89-94
Peer Reviewed
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[Presentation] Effect Of DirectHemoperfusion Using PolymixinB-Immobilized Fiber Column For PatientsWith Rapidly Progressive InterstitialPneumonias2012
Author(s)
Horio Y, Ichiyasu H, Masunaga A,Sakamoto Y, Sakata S, Tsumura S, KojimaK, Saeki S, Hirosako S, Okamoto S, FujiiK, Saita N, Kohrogi H
Organizer
American Thoracic SocietyInternational conference
Place of Presentation
San Francisco, California, USA
Year and Date
20120518-23
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[Presentation] High Prevalenceof Sleep Disordered Breathing In ChronicRespiratory Diseases: Usefullness ofNocturnal Oximetry Screening2012
Author(s)
Tsumura S, Fujii K, Horio Y, Hirosako S,Sakamoto Y, Sakata S, Sato R, MasunagaA, Saeki S, Kojima K, Okamoto S, IchiyasuH, Saita N, Kohrogi H
Organizer
AmericanThoracic Society Internationalconference
Place of Presentation
SanFrancisco, California, USA
Year and Date
20120518-23
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[Presentation] 急性呼吸不全を呈する間質性肺疾患に対する PMX-DHP 療法施行症例の臨床的検討2012
Author(s)
一安秀範, 増永愛子, 小嶋圭介, 堀尾雄甲, 坂本安見子, 坂田晋也, 津村真介,廣佐古進, 岡本真一郎, 藤井一彦, 税田直樹, 興梠博次
Organizer
第52回日本呼吸器学会学術講演会
Place of Presentation
神戸国際会議場(神戸)
Year and Date
20120420-22
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