Steroid-resistant mechanism in smoking asthma

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Wakayama Medical University
• Principal Investigator: MATSUNAGA Kazuto 和歌山県立医科大学, 医学部, 講師 (20347602)
• Project Period (FY): 2010 – 2012
• Keywords: 気管支喘息 / 喫煙 / 気道炎症 / 閉塞性障害 / 気道過敏性 / 酸化ストレス / 窒素化ストレス / ステロイド

Research Abstract

Smoking habit is an important contributor to difficult asthma. Oxidative/nitrative stress induced by smoking is assumed to be a cause of the airway remodeling. This research has demonstrated that the smoking history is an independent risk factor for persistent bronchial inflammation in steroid-treated asthma. Furthermore, our study suggested that peroxynitrite can influence tissue remodeling by promoting matrix metaloproteases release, while theophylline suppresses peroxynitrite-induced tissue remodeling via pathways involving NF-kB and/or HDAC in the fibroblasts.

Research Products

• [Journal Article] 25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells (2012)
  • Author(s): Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Kikuchi T, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
  • Journal Title: Respir Res Volume: 13 Pages: 63
  • Peer Reviewed
• [Journal Article] Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages (2012)
  • Author(s): Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
  • Journal Title: Respirology Volume: 17 Pages: 1018-1025
  • Peer Reviewed
• [Journal Article] Response to treatment in individuals with late-onset asthma (2012)
  • Author(s): Matsunaga K, Akamatsu K, Hirano T, Ichinose M
  • Journal Title: J Am Geriatric Soc Volume: 60 Pages: 1587-1588
  • Peer Reviewed
• [Journal Article] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics (2012)
  • Author(s): Matsunaga K, Yanagisawa S, Hirano T, Ichikawa T, Koarai A, Akamatsu K, Sugiura H, Minakata Y, Matsunaga K, Kawayama T, Ichinose M
  • Journal Title: Clin Exp Allergy Volume: 42(5) Pages: 775-781
  • Peer Reviewed
• [Journal Article] Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease (2012)
  • Author(s): Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Yanagisawa S, Furusawa M, Uno Y, Yamasaki M, Satomi Y, Ichinose M
  • Journal Title: Respirology Volume: 17 Pages: 533-540
  • Peer Reviewed
• [Journal Article] Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts (2012)
  • Author(s): Sugiura H, Kawabata H, Ichikawa T, Koarai A, Yanagisawa S, Kikuchi T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, Akamatsu K, Furukawa K, Ichinose M
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 302(8) Pages: 764-774
  • Peer Reviewed
• [Journal Article] Increase of 27-hydroxycholesterol in the airways of patients with chronic obstructive pulmonary disease: possible role of 27-hydroxycholesterol in tissue fibrosis (2012)
  • Author(s): Kikuchi T, Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, Akamatsu K, Yanagisawa S, Furukawa K, Kawabata H, Ichinose M
  • Journal Title: Chest Volume: 142(2) Pages: 329-337
  • Peer Reviewed
• [Journal Article] Validation of the Triaxial Accelerometer for the Evaluation of Physical Activity in Japanese Patients with COPD (2012)
  • Author(s): Kanda M, Minakata Y, Matsunaga K, Sugiura H, Hirano T, Koarai A, Akamatsu K, Ichikawa T and Ichinose M
  • Journal Title: Intern Med Volume: 51 Pages: 369-375
  • Peer Reviewed
• [Journal Article] Validation of a Compact Motion Sensor for the Measurement of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease (2012)
  • Author(s): Sugino A, Minakata Y, Kanda M, Akamatsu K, Koarai A, Hirano T, Sugiura H, Matsunaga K, Ichinose M
  • Journal Title: Respiration Volume: 83 Pages: 300-307
  • Peer Reviewed
• [Journal Article] 免疫・アレルギー-高齢者喘息と耳鼻咽喉科- (2012)
  • Author(s): 松永和人
  • Journal Title: JOHNS Volume: 28 Pages: 1429-1433
• [Journal Article] 呼吸器疾患と脳神経障害 (2012)
  • Author(s): 松永和人、一ノ瀬正和
  • Journal Title: 日本内科学会雑誌 Volume: 101 Pages: 2219-2225
  • Peer Reviewed
• [Journal Article] 典型的疾患から学ぶ呼吸機能(5)気管支喘息 (2012)
  • Author(s): 松永和人
  • Journal Title: 呼吸 Volume: 31(6) Pages: 532-537
• [Journal Article] 気道炎症モニタリングの現状と展望 (2012)
  • Author(s): 松永和人, 一ノ瀬正和
  • Journal Title: 最新 医学 Volume: 67 Pages: 1236-1242
• [Journal Article] 呼気凝縮液と気道炎症 (2012)
  • Author(s): 松永和人
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57(3) Pages: 288-293
• [Journal Article] 喘息長期管理のための炎症モニタリング (2012)
  • Author(s): 松永和人、一ノ瀬正和
  • Journal Title: 臨牀と研究 Volume: 89(3) Pages: 63-68
• [Journal Article] 成人喘息:呼気ガス・呼気凝縮液による気道炎症評価 (2012)
  • Author(s): 松永和人
  • Journal Title: アレルギー Volume: 61(1) Pages: 1-9
  • Peer Reviewed
• [Journal Article] Improvement of airflow limitation by fluticasone propionate/salmeterol in chronic obstructive pulmonary disease: what is the specific marker? (2011)
  • Author(s): Akamatsu K, Matsunaga K, Sugiura H, Koarai A, Hirano T, Minakata Y and Ichinose M
  • Journal Title: Front Pharmacol Volume: 2 Pages: 36
  • Peer Reviewed
• [Journal Article] Exhaled nitric oxide cutoff values for asthma diagnosis according to rhinitis and smoking status in Japanese subjects (2011)
  • Author(s): Matsunaga K, Hirano T, Akamatsu K, Koarai A, Sugiura H, Minakata Y, Ichinose M
  • Journal Title: Allergol Int Volume: 60 Pages: 331-337
  • Peer Reviewed
• [Journal Article] Increase of nitrosative stress in patients with eosinophilic pneumonia (2011)
  • Author(s): Furukawa K, Sugiura H, Matsunaga K,Ichikawa T, Koarai A, Hirano T, Yanagisawa S, Minakata Y, Akamatsu K, Kanda M, Nishigai M and Ichinose M
  • Journal Title: Respir Res Volume: 12 Pages: 81
  • Peer Reviewed
• [Journal Article] 呼気 NO 濃度測定:喘息補助診断の新しいツール (2011)
  • Author(s): 松永和人、一ノ瀬正和
  • Journal Title: アレルギーの臨床 Volume: 31(4) Pages: 342-346
• [Journal Article] 成人喘息の早期診断における課題と展望 (2011)
  • Author(s): 松永和人、一ノ瀬正和
  • Journal Title: アレルギーの臨床 Volume: 31(11) Pages: 27-31
• [Journal Article] Reference ranges for exhaled nitric oxide fraction in healthy Japanese adult population (2010)
  • Author(s): Matsunaga K, Hirano T, Kawayama T, Tsuburai T, Nagase H, Aizawa H, Akiyama K, Ohta K and Ichinose M
  • Journal Title: Allergol Int Volume: 59 Pages: 363-367
  • Peer Reviewed
• [Journal Article] High COPD prevalence in the patients with liver diseases (2010)
  • Author(s): Minakata Y , Ueda H, Akamatsu K, Kanda M, Yanagisawa S, Ichikawa T, Koarai A, Hirano T, Sugiura H, Matsunaga K, Ichinose M
  • Journal Title: Intern Med Volume: 49 Pages: 2687-2691
  • Peer Reviewed
• [Journal Article] Oxidative Stress Enhances Toll-like Receptor 3 Response to Double-stranded RNA in Airway Epithelial Cells. (2010)
  • Author(s): oarai A, Sugiura H, Yanagisawa S, Ichikawa T, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Ichinose M
  • Journal Title: Am J Respir Cell Mol Biol Volume: 42 Pages: 651-660
  • Peer Reviewed
• [Journal Article] 喘息発作の治療 高齢者喘息への対応 (2010)
  • Author(s): 松永和人
  • Journal Title: Mebio Volume: 27 Pages: 64-71
• [Journal Article] 呼気分析による気道炎症評価 (2010)
  • Author(s): 松永和人
  • Journal Title: 日本臨床生理学会雑誌 Volume: 40 Pages: 15-20
  • Peer Reviewed
• [Journal Article] One airway, one disease の治療戦略 ‐ロイコトリエン受容体拮抗薬‐ (2010)
  • Author(s): 松永和人, 一ノ瀬正和
  • Journal Title: 喘息 Volume: 23 Pages: 44-49
• [Journal Article] 抗コリン薬の位置付け (2010)
  • Author(s): 松永和人, 一ノ瀬正和
  • Journal Title: アレルギーの臨床 Volume: 29(14) Pages: 45-50
• [Presentation] 鼻炎合併喘息: 鼻炎の状態からみた喘息に対する影響 (2012)
  • Author(s): 松永和人, 早田敦志, 南方良章, 一ノ瀬正和
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-12-01
• [Presentation] 高齢発症喘息におけるHFA-fluticasone/salmeterol 配合剤の治療反応性. (2012)
  • Author(s): 松永和人, 早田敦志, 南方良章, 一ノ瀬正和
  • Organizer: 第62回日本アレルギー学会秋季学術大会 (ミニシンポジウム)
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-30
• [Presentation] Budesonide およびBudesonide/Formoterol による喘息指標の経時的な改善過程. (2012)
  • Author(s): 松永和人 , 川端宏樹 , 一ノ瀬正和
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-30
• [Presentation] 重症喘息における閉塞性換気障害の経年的進行パターン (2012)
  • Author(s): 松永和人, 赤松啓一郎, 宮武明彦, 藤田きみる, 一ノ瀬正和
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-29
• [Presentation] Simultaneous analysis of clinical markers for predicting increased lung function fluctability in stable asthma (2012)
  • Author(s): K. Matsunaga, A. Hayata, T. Hirano, M. Ichinose
  • Organizer: 2012 ERS Annual Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2012-09-03
• [Presentation] LATE-BREAKING ABSTRACT: Developing obstructive change over time is dominant in small airways in severe asthma (2012)
  • Author(s): K. Matsunaga, K. Akamatsu, M. Ichinose
  • Organizer: 2012 ERS Annual Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2012-09-02
• [Presentation] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics (2012)
  • Author(s): K. Matsunaga, S. Yanagisawa, T. Hirano, H. Sugiura, Y. Minakata, M. Ichinose
  • Organizer: The 22ndCongress of Interasma Japan/North Asia
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2012-07-06
• [Presentation] 気管支喘息における気道炎症評価の進歩 (2012)
  • Author(s): 松永和人
  • Organizer: 第79回日本呼吸器学会近畿地方会 (教育講演)
  • Place of Presentation: 京都市
  • Year and Date: 2012-06-30
• [Presentation] Thematic Poster Session: Evaluation Of Intensity-Based Physical Activity In Patients With COPD (2012)
  • Author(s): Y. Minakata, A. Sugino, Y. Honda, T. Ichikawa, K. Akamatsu, A. Koarai, T. Hirano, M. Nakanishi, H. Sugiura, K. Matsunaga, M Ichinose
  • Organizer: 2012 ATS International Conference
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 2012-05-23
• [Presentation] Thematic Poster Session: Persistent Exhaled Nitric Oxide Elevation And Augmentation Of Inhaled Corticosteroid Therapy In Asthma (2012)
  • Author(s): T. Hirano, K. Matsunaga, H. Sugiura, Y. Minakata, A. Koarai, K. Akamatsu, T. Ichikawa, K. Furukawa, M. Ichinose
  • Organizer: 2012 ATS International Conference
  • Place of Presentation: San Francisco, California,USA
  • Year and Date: 2012-05-23
• [Presentation] Thematic Poster Session:25-Hydroxycholesterol Enhances Interferon Release After Toll-Like Receptor 3 Stimulation In Human Airway Epithelial Cells (2012)
  • Author(s): A. Koarai, S. Yanagisawa, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Furukawa, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata, M. Ichinose
  • Organizer: 2012 ATS International Conference
  • Place of Presentation: San Francisco, California,USA
  • Year and Date: 2012-05-22
• [Presentation] ndependent Predictors Of Persistent Exhaled Nitric Oxide Elevation In Treated Asthmatics (2012)
  • Author(s): K. Matsunaga, S. Yanagisawa, T. Hirano, K. Akamatsu, A. Koarai, H. Sugiura, Y. Minakata, M. Ichinose
  • Organizer: 2012 ATS International Conference
  • Place of Presentation: San Francisco, California,USA
  • Year and Date: 2012-05-22
• [Presentation] 安定期喘息において遷延する呼気 NO 濃度上昇と関連する背景因子 (2012)
  • Author(s): 松永和人
  • Organizer: 第24回日本アレルギー学会 (ミニシンポジウム)
  • Place of Presentation: 大阪
  • Year and Date: 2012-05-12
• [Presentation] ndependent Predictors of Persistent Exhaled Nitric Oxide Elevation in Treated Asthmatics. (2012)
  • Author(s): K. Matsunaga, T . Hirano, M. Ichinose
  • Organizer: The 52nd Annals of The Japanese Respiratory Society (English symposium)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2012-04-20
• [Presentation] 高齢者喘息と COPD:オーバーラップ症候群 (2011)
  • Author(s): 松永和人
  • Organizer: 第61回日本アレルギー学会秋季学術大会 (教育セミナー)
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] 安定期喘息における PEF 変動率増大を予測する段階的アプローチの提唱 (2011)
  • Author(s): 松永和人, 早田敦司, 平野綱彦, 一ノ瀬正和
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] 呼気 NO 濃度測定の喘息補助診断における有用性と留意点 (2011)
  • Author(s): 松永和人
  • Organizer: 第48回日本小児アレルギー学会・第16回アジア太平洋小児アレルギー呼吸器免疫学会 (シンポジウム)
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-28
• [Presentation] Thematic Poster Session:Increase of 25-hydroxycholesterol in the lungs of chronic obstructive pulmonary disease (2011)
  • Author(s): H. Sugiura, A. Koarai, T . Ichikawa, Y. Minakata, K. Matsunaga, T. Hirano, K. Akamatsu, S. Yanagisawa, M. Furusawa, Y. Uno, M. Yamasaki, M.Ichinose
  • Organizer: 201 1 ERS Annual Congress
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-09-27
• [Presentation] Thematic Poster Session:Validation of a compact accelerometer for the measurement of physical activity in patients with COPD (2011)
  • Author(s): Y. Minakata, A. Sugino, M. Nishigai, M.Kanda, K. Akamatsu, A. Koarai, T. Hirano, H. Sugiura, K. Matsunaga, M. Ichinose
  • Organizer: 2011ERS Annual Congress
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-09-26
• [Presentation] Thematic Poster Session: Increase of nitrosative stress in patients with eosinophilic pneumonia (2011)
  • Author(s): K. Furukawa, H. Sugiura, K. Matsunaga, T. Ichikawa, A. Koarai, T. Hirano, M. Kanda, K. Akamatsu, Y. Minakata, M. Nishigai, M. Ichinose
  • Organizer: 2011 ERS Annual Congress
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-09-25
• [Presentation] OralPresentation Session: Cigarette smoking augments toll-like receptor 3expression and responses in macrophages (2011)
  • Author(s): A. Koarai, S. Yanagisawa, H. Sugiura, T. Ichikawa, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata, and M. Ichinose
  • Organizer: ERS Annual Congress
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-09-25
• [Presentation] Optimization of diagnosis and long-term management in elderly asthmatics (2011)
  • Author(s): K. Matsunaga
  • Organizer: The 21st Congress of Interasma Japan/North Asia
  • Place of Presentation: Gifu, Japan
  • Year and Date: 2011-07-01
• [Presentation] hematic Poster Session: 25-hydroxycholesterol enhances cytokines release and toll-like receptor 3 responses in human airway epithelial cells (2011)
  • Author(s): A. Koarai, S. Yanagisawa, H. Sugiura, T. Ichikawa, H. Kawabata, T. Kikuchi, M. Kanda, K. Furukawa, K. Akamatsu, T. Hirano, K. Matsunaga, Y. Minakata and M.Ichinose
  • Organizer: 2011 ATS International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-17
• [Presentation] Differences In Cutoff Values Of Exhaled Nitric Oxide For Asthma Diagnosis According To Rhinitis And Smoking Status (2011)
  • Author(s): K. Matsunaga, T. Hirano, A. Koarai, K. Akamatsu, H. Sugiura, Y. Minakata and M. Ichinose
  • Organizer: 2011 ATS International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-17
• [Presentation] Thematic poster session: Increased27-hydroxycholesterol Production In The Airways Of Chronic ObstructivePulmonary Disease (2011)
  • Author(s): T. Kikuchi, H. Sugiura, A. Koarai, T. Ichikawa, Y. Minakata, K. Matsunaga, M. Nakanishi, T. Hirano, K. Akamatsu, S. Yanagisawa, K. Furukawa, M. Kanda, H. Kawabata, M. Ichinose
  • Organizer: 2011 ATS International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-16
• [Presentation] Thematic Poster Session: Increase of25-hydroxycholesterol in the lungs of chronic obstructive pulmonary disease (2011)
  • Author(s): H. Sugiura, A. Koarai, T. Ichikawa, Y. Minakata, K. Matsunaga, T. Hirano, K. Akamatsu, S. Yanagisawa, M. Furusawa, Y. Uno, M. Yamasaki, Y.Satomi, M. Ichinose
  • Organizer: 2011 ATS International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-16
• [Presentation] Relationship Between Inflammatory Markers In Exhaled Air And Small Airway Function In Chronic Obstructive Pulmonary Disease(COPD) (2011)
  • Author(s): T. Hirano, K. Matsunaga, Y. Minakata, H. Sugiura, M. Nakanishi, A. Koarai, K. Akamatsu, T. Ichikawa, S. Yanagisawa, M. Furusawa, M. Kanda, T. Kikuchi, H. Kawabata, M. Ichinose
  • Organizer: 2011 ATSInternational Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-15
• [Presentation] 松永和人 (2011)
  • Author(s): 松永和人
  • Organizer: 第23回日本アレルギー学会春季臨床大会 (シンポジウム)
  • Place of Presentation: 千葉
  • Year and Date: 2011-05-14
• [Presentation] Thematic Poster Session: Expression of toll-like receptor 3 in alveolar macrophages from patients with COPD (2010)
  • Author(s): A. Koarai, S. Yanagisawa, H. Sugiura,T . Ichikawa, M. Kanda, K. Furukawa, K. Akamatsu, T . Hirano, K. Matsunaga, Y . Minakata, M. Ichinose
  • Organizer: 2010 ERS Annual Congress 2010.09.18-22
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20100918-22
• [Presentation] 喘息診断に用いる呼気 NO濃度カットオフ値の提唱 (2010)
  • Author(s): 松永和人, 平野綱彦, 川端宏樹, 神田匡兄, 柳澤 悟, 市川朋宏 , 小荒井晃, 赤松啓一郎, 中西正典, 杉浦久敏, 南方良章, 一ノ瀬正和
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells (2010)
  • Author(s): A. Koarai, H. Sugiura, S. Yanagisawa, T. Ichikawa, Y. Minakata, K. Matsunaga, T. Hirano, K. Akamatsu and M. Ichinose
  • Organizer: Tokyo Asia COPD symposium 2010 Tokyo
  • Place of Presentation: Tokyo
  • Year and Date: 2010-07-31
• [Presentation] Peroxynitorite augments fibroblast-mediated tissue remodeling through NF-Kβ activation (2010)
  • Author(s): T. Ichikawa, H. Sugiura, A. Koarai, S. Yanagisawa, M. Kanda, K. Akamatsu, T. Hirano, K. Matsunaga, Y. Minakata, M. Ichinose
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-18
• [Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells (2010)
  • Author(s): A. Koarai, H. Sugiura, S. Yanagisawa, T. Ichikawa, Y. Minakata, K. Matsunaga, T. Hirano, K. Akamatsu and M. Ichinose
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-16
• [Presentation] Oxydative Stress Augments Toll-Like Receptor 8 Mediated Neutrophilic Responses (2010)
  • Author(s): S. Yanagisawa, A. Koarai, H. Sugiura, T. Ichikawa, M. Kanda, K. Akamatsu, T. Hirano, K. Matsunaga, Y. Minakata, M. Ichinose
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-16
• [Presentation] 喫煙喘息における呼気 NO 濃度 (2010)
  • Author(s): 松永和人, 神田匡兄,柳澤悟,市川朋宏,小荒井晃,赤松啓一郎, 平野綱彦,杉浦久敏,南方良章,一ノ瀬正和
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-08
• [Presentation] 喘息診断における呼気 NO 濃度のカットオフ値 (2010)
  • Author(s): 松永和人, 神田匡兄, 柳澤 悟, 市川朋宏, 小荒井晃, 赤松啓一郎, 平野綱彦, 杉浦久敏, 南方良章, 一ノ瀬正和
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-08
• [Presentation] 喫煙喘息における呼気 NO 濃度 (2010)
  • Author(s): 松永和人, 神田匡兄,柳澤 悟,市川朋宏,小荒井晃,赤松啓一郎, 平野綱彦,杉浦久敏,南方良章,一ノ瀬正和
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京 都
  • Year and Date: 2010-04-23
• [Book] 気管支喘息(成人喘息とは), 一般社団法人 日本アレルギー学会 編集 臨床医のためのアレルギー診療ガイドブック (2012)
  • Author(s): 松永和人, 一ノ瀬正和:
  • Total Pages: 47-52
  • Publisher: 診断と治療社
• [Book] 検査・鑑別・重症度(判定), 一般社団法人 日本アレルギー学会 編集 臨床医のためのアレルギー診療ガイドブック (2012)
  • Author(s): 松永和人, 一ノ瀬正和
  • Total Pages: 53-59
  • Publisher: 診断と治療社
• [Book] 難治性喘息. アレルギー・リウマチ膠原病診療 最新ガイドライン. (2012)
  • Author(s): 松永和人, 一ノ瀬正和
  • Total Pages: 6-9
  • Publisher: 総合医学社
• [Book] 気管支喘息. 新呼吸療法テキスト (2012)
  • Author(s): 松永和人, 一ノ瀬正和
  • Total Pages: 252-256
  • Publisher: アトムス
• [Book] 喘息治療管理のモニタリング法の今後の見通しは?EBM アレルギー疾患の治療2010-2011 (2009)
  • Author(s): 松永和人、一ノ瀬正和
  • Total Pages: 69-73
  • Publisher: 中外医学社