2012 Fiscal Year Final Research Report
Mechanisms of Interleukin-13 and B1 cells upon prognosis of acute infectious diseases
| Project/Area Number |
22591103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
YAMAMOTO Natsuo 福島県立医科大学, 感染制御医学講座, 講師 (50466562)
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| Project Period (FY) |
2010 – 2012
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| Keywords | IL-13 / 自然抗体 / IgM / M2 マクロファージ |
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| Research Abstract |
IL-13 is Th2 type cytokine as investigated in various physiological functions. Pathogen elimination was impaired in IL-13 deficient (KO) mice when we challenged low dose live S. pneumoniae, or C. albicans via airway route, compared to BALB/c wild type (WT). Serum natural IgM titer was lower in IL-13 KO compared to control WT. IL-13 may affect to amount and quality of natural IgM in the primary acute infection model.
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