2012 Fiscal Year Final Research Report
Tropism determined by gene product of Herpes Simplex Virus is a natural barrier in mother-to-infant transmission
| Project/Area Number |
22591104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | University of Toyama |
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Principal Investigator |
DAIKOKU Tohru 富山大学, 大学院・医学薬学研究部(医学), 准教授 (80291409)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 感染症防御学 / 母子感染 / 単純ヘルペスウイルス |
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| Research Abstract |
Mother-to-infant transmission of herpes simplex virus （HSV) is rare but has serious consequences. In two cases of paired HSV isolates from mother and infant, infantile isolates showed significantly better HepG2 hepatoblastoma cell-tropism and temperature adaptation in Vero cells than maternal isolates, and they had a mutation in common, which might have altered the characters of the infantile virus compared to the maternal virus. Generation of a mutation in the HSV infecting infants conferred altered cell tropisms, indicating that tropism acquisition by generation of the mutation for infecting viruses is a natural barrier to protect infants from mother-to-infant transmission of HSV
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[Journal Article] Microemulsion-Based Oxyresveratrol for Topical Treatment of Herpes Simplex Virus (HSV) Infection: Physicochemical Properties and Efficacy in Cutaneous HSV-1 Infection in Mice2012
Author(s)
Sasivimolphan P, Lipipun V, Ritthidej G, Chitphet K, Yoshida Y, Daikoku T, Sritularak B, Likhitwitayawuid K, Pramyothin P, Hattori M, Shiraki K
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Journal Title
AAPS Pharmacological Science Technology
Volume: 13(4)
Pages: 1266-1275
DOI
Peer Reviewed
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[Journal Article] Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo.2012
Author(s)
Himaki T, Masui Y, Chono K, Daikoku T, Takemoto M, Haixia B, Okuda T, Suzuki H, Shiraki K.
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Journal Title
Antiviral Research.
Volume: 93(2)
Pages: 301-304
DOI
Peer Reviewed
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[Journal Article] Polyphenols including catechin from green tea with in vitro antiviral activity exhibited anti-herpes simplex virus activity but not anti-influenza virus.2011
Author(s)
Daikoku T, Horiba K, Miyata K, Takemoto M, Okuda T, Yoshida Y, Sawamura R, Imakita M, Okubo T, Nagaura Y, Kurokawa M, Shiraki K.
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Journal Title
Journal of Traditional Medicines.
Volume: 28 (1) No. 2
Pages: 63-72
Peer Reviewed
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[Journal Article] Widespread circulation of echovirus type 13 demonstrated by increased seroprevalence in Toyama, Japan, between 2000 and 2003.2010
Author(s)
Iwai M, Yoshida H, Obara M, Horimoto E, Nakamura K, Takizawa T, Kurata T, Mizuguchi M, Daikoku T, Shiraki K.
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Journal Title
Clinical Vaccine Immunology
Volume: 17(5)
Pages: 764-770
DOI
Peer Reviewed
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[Journal Article] Antibody to Varicella-Zoster Virus Immediate Early 62 Augments Allodynia in Zoster via Brain-Derived Neurotrophic Factor (BDNF).2010
Author(s)
Hama Y, Shiraki K , Yoshida Y, Maruyama A, Yasuda M, Tsuda M, Honda M, Takahashi M, Higuchi H, Takasaki I, Daikoku T, Tsumoto T.
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Journal Title
Journal of Virology.
Volume: 84(3)
Pages: 1616-1624
DOI
Peer Reviewed
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