2012 Fiscal Year Final Research Report
A mechanism of platelet phagocytosis in dengue virus infection
| Project/Area Number |
22591106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | National Institute of Infectious Diseases (2012)
Osaka University (2010-2011) |
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Principal Investigator |
OISHI Kazunori 国立感染症研究所, 感染症情報センター, センター長 (80160414)
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| Co-Investigator(Kenkyū-buntansha) |
KUROSU Takeshi 大阪大学, 微生物病研究所, 助教 (70432432)
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| Project Period (FY) |
2010 – 2012
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| Keywords | デングウイルス / 血小板減少 / 血小板アポトーシス |
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| Research Abstract |
Dengue illness has become a major public health concern particularly in tropical countries and the mechanism of thrombocytopenia remains uncertain. We previously reported from the clinical study in the Philippines a significant association between thrombocytopenia and an increased phagocytosis of platelets in an ex vivo setting during acute phase of secondary dengue virus infection (Honda S, et al. Am J Trop Med Hyg, 2009). We report here an increased phagocytosis of DV-induced apoptotic platelets by macrophages via a phosphatidylserine-recognizing pathway in secondary DV infection during the acute phase. Accelerated platelet clearance was overcome by thrombopietin-induced enhanced thrombopoiesis in these patients (Alonzo T, et al. J infect Dis, 2012).
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Research Products
(6 results)
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[Journal Article] Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection.2013
Author(s)
Sasaki T, Setthapramote C, Kurosu T, Nishimura M, Asai A, Omokoko MD, Pipattanaboon C, Pitaksajjakul P, Limkittikul K, Subchareon A, Chaichana P, Okabayashi T, Hirai I, Leaungwutiwong P, Misaki R, Fujiyama K, Ono K, Okuno Y, Ramasoota P, Ikuta K
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Journal Title
Antiviral Res
Volume: 98(3)
Pages: 423-31
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[Journal Article] Platelet apoptosis and apoptotic platelet clearance by macrophages in secondary dengue virus infections.2012
Author(s)
Alonzo MTG, Lacuesta TLV, Dimaano EM, Kurosu T, Suarez LC, Mapua CA, Akeda Y, Matias RR, Kuter DJ, Nagata S, Natividad FF, Oishi K
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Journal Title
J Infect Dis
Volume: 205(8)
Pages: 1321-9
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[Journal Article] Limited cross-reactivity of mouse monoclonal antibodies against Dengue virus capsid protein among four serotypes.2012
Author(s)
Noda M, Masrinoul P, Punkum C, Pipattanaboon C, Ramasoota P, Setthapramote C, Sasaki T, Sasayama M, Yamashita A, Kurosu T, Ikuta K, Okabayashi T
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Journal Title
Biologics
Volume: 6
Pages: 409-16
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