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2012 Fiscal Year Final Research Report

An analysis of the effects of the host cell on antibacterial chemotherapy

Research Project

  • PDF
Project/Area Number 22591114
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Infectious disease medicine
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

TAKEMURA Hiromu  聖マリアンナ医科大学, 医学部, 教授 (80301597)

Project Period (FY) 2010 – 2012
Keywords感染症治療学 / 臨床微生物学
Research Abstract

We observed the influence of the host cells, human alveolar epithelial cells, monocytes and macrophages, on the antimicrobial activities of several antibiotics and we found antimicrobial activities of carbapenems (Cps) were decreased in the supernatant of the cells cultured with fetal calf serum (FCS)-free RPMI 1640 medium. The farther studies revealed human cell culture supernatants to decline the antibacterial activities of Cps. We developed a useful screening test for the combination of piperacillin and aminoglycosides for multidrug-resistant Pseudomonas aeruginosa (MDRP) using the disk diffusion based method. We presented the usefulness of this method compared with the Etest based method and the checkerboard method.

  • Research Products

    (3 results)

All 2013 2012 2011

All Presentation (3 results)

  • [Presentation] A549細胞の培養上清はカルバペネム薬の抗菌活性を不活化する2013

    • Author(s)
      竹村弘、他4名
    • Organizer
      第61回日本化学療法学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-06-05
  • [Presentation] A549 Cell Culture Supernatant Inactivates Carbapenem Antibiotics2012

    • Author(s)
      H Takemura、他4名
    • Place of Presentation
      サンフランシスコ(米国)
    • Year and Date
      2012-09-10
  • [Presentation] A Simple Screening Test for Synergy of Piperacillin and Aminoglycosides against Multidrug-resistant Pseudomonas aeruginosa using Disk Diffusion Test2011

    • Author(s)
      H Takemura、他 6 名
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2011-09-18

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Published: 2014-08-29   Modified: 2015-10-20  

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