2012 Fiscal Year Final Research Report
Application of anti-crytpococcal cell surface protein antibody against latent infection diagnosis and control of severe diseases of cryptococcosis
| Project/Area Number |
22591115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
OHNO Hideaki 国立感染症研究所, 生物活性物質部, 室長 (20325640)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGOE Satoshi 国立感染症研究所, 生物活性物質部, 主任研究官 (00212283)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 日和見感染症 |
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| Research Abstract |
Cell surface and secretory proteins of Cryptococcus neoformans were detected using signal sequence trap (SST) method, and monoclonal antibodies against one of those proteins were obtained. In addition, the possibility of detection of latent infection diagnosis and controlling severe cryptococcal diseases applying with antibodies were also evaluated. Consequently, the protein was confirmed on cell wall and to be secreted outside cell under both aerobic and anaerobic conditions, and it speculated that it was a candidate protein on diagnosis of Cryptococcus latent infection, however, that protein seemed to have no relevance with cell growth.
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[Journal Article] Determination of epidemiology of clinically isolated Cryptococcus neoformans strains in Japan by multilocus sequence typing.2013
Author(s)
Umeyama T, Ohno H, Minamoto F, Takagi T, Tanamachi C, Tanabe K, Kaneko Y, Yamagoe S, Kishi K, Fujii T, Takemura H, Watanabe H, Miyazaki Y
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Journal Title
Jpn J Infect Dis
Volume: 66
Pages: 51-55
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[Journal Article] Multilocus sequence typing of Cryptococcus neoformans in non-HIV associated cryptococcosis in Nagasaki, Japan.2013
Author(s)
Mihara T, Izumikawa K, Kakeya H, Ngamskulrungroj P, Umeyama T, Takazono T, Tashiro M, Nakamura S, Imamura Y, Miyazaki T, Ohno H, Yamamoto Y, Yanagihara K, Miyazaki Y, Kohno S
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Journal Title
Med Mycol
Volume: 51 (3)
Pages: 252-260
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[Journal Article] Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata2011
Author(s)
Nagi M, Nakayama H, Tanabe K, Bard M, Aoyama T, Okano M, Higashi S, Ueno K, Chibana H, Niimi M, Yamagoe S, Umeyama T, Kajiwara S, Ohno H, Miyazaki Y
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Journal Title
Genes Cells
Volume: 16
Pages: 80-89
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