2012 Fiscal Year Final Research Report
Mechanisms of impaired neutrophil functions by clinical isolates from bacteremia
| Project/Area Number |
22591116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
ATO Manabu 国立感染症研究所, 免疫部, 室長 (20392318)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNISHI Makoto 国立感染症研究所, 細菌第一部, 部長 (10233214)
IKEBE Tadayoshi 国立感染症研究所, 細菌第一部, 主任研究官 (20333362)
KURODA Makoto 国立感染症研究所, 病原体ゲノム解析研究センター, センター長 (80317411)
TOBIUME Minoru 国立感染症研究所, 感染病理部, 主任研究官 (60370962)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 感染症 / 免疫学 / 細菌 |
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| Research Abstract |
Sepsis and disseminated bacterial infection is caused by various bacteria and affected to not only compromised hosts but healthy people without apparent trauma. In this study, we aim to unveil a novel neutrophil-bacteria interaction which regulates host defense by analysis of modification of neutrophil defense functions by screening using human neutrophils and mouse models. Here we show that clinical isolates from severe invasive streptococcus infection have a license to kill neutrophils by streptolysin O, a pore-forming toxin in a contact-depending manner. We demonstrate that clinical isolates from septic melioidosis could suppress the release of neutrophil extracellular traps (NETs), which kill bacteria extracellularly. We further identified bacterial virulence factors responsible to modification of NETs release. These findings are expected to contribute to understanding pathogenesis of invasive bacteria infections.
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