Elucidation of the molecular basis of the permeation of norovirus in an area

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591117
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Toyama Institute of Health
• Principal Investigator: TAKIZAWA Takenori 富山県衛生研究所, ウイルス部, 部長 (40192158)
• Co-Investigator(Renkei-kenkyūsha): ITAMOCI Masae (IWAI Masae) 富山県衛生研究所, ウイルス部, 主任研究員 (70393080) ; NAGOYA Mayumi (OBARA Mayumi) 富山県衛生研究所, ウイルス部, ウイルス部 (80393081)
• Project Period (FY): 2010 – 2012
• Keywords: ノロウイルス / 疫学 / 感染性胃腸炎 / 遺伝子変異

Research Abstract

There are many genotypes in norovirus (NoV), and NoV causes outbreak repeatedly with high frequency of mutation. In this research, NoV genes detected from patients and sewer influents were compared to understand the molecular basis of the outbreak in an area. While genotype GI.4 was mainly detected from sewer influents for long period with less frequency of mutation, different recombinant variants or subtypes of GII.2, 3, or 4, respectively appeared rise and fall in outbreaks for every season. It was suggested that the genotypes causing an apparent interaction with a host show higher genetic variations.

Research Products

• [Journal Article] ウイルス性胃腸炎の集団発生事例及び散発例について(2011 年度) (2012)
  • Author(s): 名古屋(小原)真弓、森岡誠二、堀元栄詞、板持(岩井)雅恵、小渕正次、滝澤剛則
  • Journal Title: 富山県衛生研究所年報 Volume: 35巻 Pages: 74-79
• [Journal Article] Endemic transmission of echovirus 30 in Toyama, 2010 verified by environmental surveillance (2011)
  • Author(s): Masae Iwai, Eiji Horimoto, Mayumi Obara, Masatsugu Obuchi, Takeshi Kurata, Kumiko Kawagoshi, Sumika Nakamura, Hiroyuki Shimizu, Hiromu Yoshida, and Takenori Takizawa
  • Journal Title: Japanese Journal of Infectious Diseases Volume: Vol.64 Pages: 163-167
  • Peer Reviewed
• [Journal Article] ウイルス性胃腸炎の集団発生事例及び散発例について(2010年度) (2011)
  • Author(s): 小原真弓、森岡誠二、小渕正次、岩井雅恵、堀元栄詞、滝澤剛則
  • Journal Title: 富山県衛生研究所年報 Volume: 34巻 Pages: 74-79
• [Journal Article] Frequent Detection of Noroviruses and Sapoviruses in Swine Population and High Genetic Diversity of Porcine Sapovirus in Japan, during fiscal year 2008 (2010)
  • Author(s): Nakamura K, Saga Y, Iwai M, Obara M, Horimoto E, Hasegawa S, Kurata T, Okumura H, Nagoshi M and Takizawa T
  • Journal Title: Journal of Clinical Microbiology Volume: Vol. 48 Pages: 1215-1222
  • Peer Reviewed
• [Journal Article] High prevalence of echovirus type 13 in Toyama, Japan in 2002 confirmed by seroepidemiological study (2010)
  • Author(s): Masae Iwai, Eiji Horimoto, Mayumi Obara, Masatsugu Obuchi, Takeshi Kurata, Kumiko Kawagoshi, Sumika Nakamura, Hiroyuki Shimizu, Hiromu Yoshida, and Takenori Takizawa
  • Journal Title: Clinical and Vaccine Immunology Volume: Vol. 17 Pages: 764-770
  • Peer Reviewed
• [Journal Article] Divergent Evolution of Norovirus GII/4 by Genome Recombination from May 2006 to February 2009 in Japan (2010)
  • Author(s): Kazushi Motomura, Masaru Yokoyama, Hirotaka Ode, Hiromi Nakamura, Hiromi Mori, Tadahito Kanda, Tomoichiro Oka, Kazuhiko Katayama, Mamoru Noda, Tomoyuki Tanaka, Naokazu Takeda, Hironori Sato, and the Norovirus Surveillance Group of Japan (Takenori Takizawa)
  • Journal Title: Journal of Virology Volume: Vol.84 Pages: 8085-8097
  • Peer Reviewed
• [Journal Article] 当院における小児ウイルス性下痢症の臨床的及びウイルス学的検討(2002年～2008年) (2010)
  • Author(s): 宗玄俊一、小原真弓、長谷川澄代、岩井雅恵、滝澤剛則
  • Journal Title: 小児感染免疫 Volume: 22巻 Pages: 23-28
  • Peer Reviewed
• [Journal Article] ウイルス性胃腸炎の集団発生事例及び散発例について(2009年度) (2010)
  • Author(s): 小原真弓、長谷川澄代、森岡誠二、中村一哉、岩井雅恵、堀元栄詞、倉田毅、滝澤剛則
  • Journal Title: 富山県衛生研究所年報 Volume: 33巻 Pages: 97-102
• [Presentation] 富山県における集団発生事例からのノロウイルス検出状況(平成22年度) (2013)
  • Author(s): 滝澤剛則,小原真弓
  • Organizer: 平成22年度地方衛生研究所全国協議会東海北陸支部微生物部会
  • Place of Presentation: 福井市
  • Year and Date: 20130303-04
• [Presentation] 富山県における2011/2012シーズンのウイルス性胃腸炎発生状況 (2013)
  • Author(s): 稲崎倫子、名古屋(小原)真弓、堀元栄詞、嶋一世、小渕正次、佐多徹太郎、滝澤剛則
  • Organizer: 第47回富山県公衆衛生学会
  • Place of Presentation: 富山市
  • Year and Date: 2013-02-07
• [Presentation] ノロウイルスにおけるキメラウイルスが感染性胃腸炎の流行に与える影響 (2012)
  • Author(s): 名古屋(小原)真弓,板持(岩井)雅恵,稲崎倫子,堀元栄詞,小渕正次,佐多徹太郎,滝澤剛則
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 20121114-15
• [Presentation] 富山県における胃腸炎ウイルス検出状況 (2012)
  • Author(s): 名古屋(小原)真弓
  • Organizer: 平成23年度地方衛生研究所全国協議会東海北陸支部微生物部会
  • Place of Presentation: 岐阜市
  • Year and Date: 20120301-02
• [Presentation] ノロウイルス組換え株が感染性胃腸炎の流行に与える影響 (2012)
  • Author(s): 佐多徹太郎,名古屋(小原)真弓,滝澤剛則
  • Organizer: 平成24年度北陸腸内細菌研究会研究発表会
  • Place of Presentation: 金沢市
  • Year and Date: 2012-07-14
• [Presentation] 富山県における過去3年間のウイルス性胃腸炎発生状況 (2012)
  • Author(s): 名古屋(小原)真弓、板持(岩井)雅恵、堀元栄詞、小渕正次、佐多徹太郎、滝澤剛則
  • Organizer: 第46回富山県公衆衛生学会
  • Place of Presentation: 富山市
  • Year and Date: 2012-02-09
• [Presentation] Recombinant noroviruses of GII.3 prevalent from 2003 to 2010 in Toyama prefecture, Japan (2011)
  • Author(s): Mayumi Obara, Masae Iwai, Masatsugu Obuchi, Eiji Horimoto, Takeshi Kurata, Takenori Takizawa
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: Sapporo City
  • Year and Date: 20110911-16