Analysis of cell differentiation machinery regulated by ATM

2012 Fiscal Year Final Research Report

• Project/Area Number: 22591121
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: PIAO Jinhua 東京医科歯科大学, 大学院・医歯学総合研究科, メディカルフェロー (70567750)
• Co-Investigator(Kenkyū-buntansha): TAKAGI Masatoshi 東京医科歯科大学, 大学院・, 講師 (10406267) ; SUGIMOTO Masataka 国立長寿医療センター, 研究所, プロジェク トリーダー (50426491)
• Project Period (FY): 2010 – 2012
• Keywords: 小児腫瘍学 / PARP阻害剤 / 急性リンパ性白血病

Research Abstract

Adipocyte differentiation and lymphocyte differentiation is attenuated in Ataxia Telangiectasia. ATM is essential for cellular differentiation machinery. Differentiation disorder is due to histone acetylation deficiency or discordance of genomic repair and cell cycle regulation.

Research Products

• [Journal Article] Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM (2012)
  • Author(s): Isoda T, Takagi M, Piao J, Nakagama S,Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
  • Journal Title: Blood Volume: 120(4) Pages: 789-9
  • DOI: doi:10.1182/blood-2012-02-413195
  • Peer Reviewed
• [Journal Article] 毛細血管拡張性運動失調症Ataxia Telangiectasiaと関連疾患 (2012)
  • Author(s): 高木正稔
  • Journal Title: メディカル・サイエンス・ダイジェスト Volume: 38(1) Pages: 17-20
• [Journal Article] AtaxiaTelangiectasiaにおけるミトコンドリア異常 (2012)
  • Author(s): 金子節子,高木正稔
  • Journal Title: 血液内科 Volume: 65(6) Pages: 825-31
• [Journal Article] Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation (2011)
  • Author(s): Nakamura H,Kawagishi H,Watanabe A, Sugimoto K, Maruyama M, Sugimoto M
  • Journal Title: Mol Cell Biol Pages: 101997-2009
  • DOI: doi:10.1128/MCB.01424-10.413195
  • Peer Reviewed
• [Presentation] ATM欠損T細胞分化のDN期におけるTリンパ球減少の原因と染色体転座の関係 (2012)
  • Author(s): 磯田健志,高木正稔,朴今花,増田喬子,伊川友活,東みゆき,森尾友宏,河本宏,水谷修紀
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20120420-22
• [Presentation] Derivation of neural stem cell via iPS cell from ataxia telangiectasia (2012)
  • Author(s): Kaneko S, Takagi M, Fukawatase Y, Umezawa A, Mizutani S
  • Organizer: 14th International workshop on Ataxia Telangiectasia
  • Place of Presentation: Delhi, India
  • Year and Date: 20120207-11
• [Presentation] Visualization of chromosomal translocation and early T-cell development failure in ATM deficiency (2012)
  • Author(s): Isoda T, Takagi, M, Piao J, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
  • Organizer: 14th International workshop on AtaxiaTelangiectasia
  • Place of Presentation: Delhi, India
  • Year and Date: 20120207-11
• [Presentation] T-Cell Development Failure At β-Selection Checkpoint and TCRα/δ Locus Break Formation Associated with Chromosome 14Translocation in Ataxia-Telangiectagia Mutated Deficient Mice (2011)
  • Author(s): Isoda T, Takagi M, Piao J, Nakagama S, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
  • Organizer: 53^<rd> American society of hematology, annual meeting
  • Place of Presentation: San Diego
  • Year and Date: 20111210-13
• [Presentation] 毛細血管運動失調症の Double Negative 期におけるT リンパ球分化異常と発がんメカニズムの関係 (2011)
  • Author(s): 磯田健志,高木正稔,朴今花,増田喬子,井川友活,東みゆき,森尾友宏,河本宏,水谷修紀
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 20111125-27
• [Presentation] DN3 T-cell development failurein Ataxia telangiectagia (AT) (2011)
  • Author(s): Isoda T, Takagi M, Piao J, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 20111014-16
• [Presentation] 毛細血管拡張性小脳失調症(AtaxiaTelangiectagia)におけるT細胞分化異常の解析 (2011)
  • Author(s): 磯田健志,高木正稔,森尾友宏,水谷修紀
  • Organizer: 日本臨床免疫学会会誌
  • Year and Date: 20110000