2012 Fiscal Year Final Research Report
Neurofunctional/neuroanatomical investigation for frontal lobe dysfunction in children with epilepsy
| Project/Area Number |
22591124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KANEMURA Hideaki 山梨大学, 大学院・医学工学総合研究部, 助教 (40359724)
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| Co-Investigator(Kenkyū-buntansha) |
AIHARA Masao 山梨大学, 医学工学総合研究部, 教授 (30242639)
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| Project Period (FY) |
2010 – 2012
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| Keywords | てんかん / 前頭葉 / 前頭前野 / 高次脳機能 / 脳波 / 突発波頻度 / QOL |
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| Research Abstract |
By using 3D-MRI volumetric analyses, we confirmed that seizureand the duration of paroxysmal anomalies may be associated withprefrontal lobe growth abnormalities, which are associated with neuropsychological problems in children with epilepsy. Moreover, we confirmed that a combination of spike rate and extended periods of high frequency of paroxysmal EEG abnormalities may predict the evolution of atypical rolandic epilepsy. The urgent suppression of these seizure and EEG abnormalities may be necessary to prevent the progression of neuropsychological impairments.
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