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2012 Fiscal Year Final Research Report

Clinical and basic studies on the dynamics of ghrelin in Rett syndrome (RTT) together with a pilot-study on the clinical implication of ghrelin for the treatment of RTT-patients.

Research Project

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Project/Area Number 22591145
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKurume University

Principal Investigator

NISHI Yoshihiro  久留米大学, 医学部, 講師 (20352122)

Co-Investigator(Kenkyū-buntansha) MATSUISHI Toyojiro  久留米大学, 医学部, 教授 (60157237)
KAWAHARA Yukie  久留米大学, 医学部, 講師 (10279135)
MIFUNE Hiroharu  久留米大学, 医学部, 准教授 (70174117)
TANAKA Eiichiro  久留米大学, 医学部, 教授 (80188284)
YAMASHITA Yusihro  久留米大学, 医学部, 准教授 (90211630)
Co-Investigator(Renkei-kenkyūsha) KOJIMA Masayasu  久留米大学, 医学部, 教授 (20202062)
TAKAHASHI Tomoyuki  久留米大学, 医学部, 准教授 (20332687)
Project Period (FY) 2010 – 2012
Keywords発達小児科学 / Rett 症候群 / グレリン / 神経内分泌調節
Research Abstract

In this study, we investigated the dynamics of ghrelin production in patients with Rett syndrome (RTT) together with that in mecp2-null mouse model of RTT (RTT-mouse). We also examined the effectiveness of “ghrelin-injection” on several clinical symptoms of RTT by using this RTT-mouse. Plasma levels of ghrelin were significantly lower in RTT patients with eating disorder or patients with insufficiency in gastro-intestinal movement. Deregulation of ghrelin production was also noted in the RTT-mouse. Daily injection of ghrelin into the RTT-mouse ameliorated the clinical symptom of them including “tremor”, “gait disturbance”, “hindlimb clasping” and “malnutrition” (body weight loss) from 6-9 weeks age. These findings of us support the future implication of “ghrelin-treatment” against several clinical symptoms typically seen in RTT patients.

  • Research Products

    (27 results)

All 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Different A-type Natriuretic Peptide Level in Five Strains of Mice.2012

    • Author(s)
      Mifune H, Nishi Y, Tajiri Y, Yabuki A.
    • Journal Title

      The Journal of VeterinaryMedical Science

      Volume: 74 Pages: 499-50

    • Peer Reviewed
  • [Journal Article] Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic torii rats.2012

    • Author(s)
      Mifune H, Nishi Y, Tajiri Y, Taku M, Hosoda H, Kangawa K and Kojima M.
    • Journal Title

      Metabolism (clinical and experimental)

      Volume: 61 Pages: 491-495

    • Peer Reviewed
  • [Journal Article] A-type natriuretic peptide level in angiotensin II type 1a-receptor knockout mice.2012

    • Author(s)
      Mifune H, Nishi Y, Tajiri Y and Yabuki A.
    • Journal Title

      Experimental Animals

      Volume: 62 Pages: 31-38

    • Peer Reviewed
  • [Journal Article] Disrupted regulation of ghrelin production under anti-hypertensive treatment in spontaneouslyhypertensive rats.2012

    • Author(s)
      Hamada N, Nishi Y, Tajiri Y, Hosoda H, Kangawa K, Kojima M and Mifune H
    • Journal Title

      Circulation Journal

      Volume: 76 Pages: 1423-1429

    • Peer Reviewed
  • [Journal Article] Ghrelin acylation by Ingestion of Medium-Chain Fatty Acids2012

    • Author(s)
      Nishi Y, Mifune H, Kojima M
    • Journal Title

      Methods in Enzymology

      Volume: 514 Pages: 303-315

    • Peer Reviewed
  • [Journal Article] Ghrelin levels are reduced in Rett syndrome with eating difficulties.2011

    • Author(s)
      Hara M, Nishi Y, Yamashita Y, Yoh J, Takahashi S, Nagamitsu S, Kakuma T, Hosoda H, Kangawa K, Kojima M, Matsuishi T.
    • Journal Title

      International Journal of Develop-mental Neuroscience

      Volume: 29 Pages: 899-902

    • Peer Reviewed
  • [Journal Article] Structures and molecular forms of ghrelin family peptides.2011

    • Author(s)
      Nishi Y, Yoh J, Hiejima H and Kojima M.
    • Journal Title

      Peptides (an International Journal)

      Volume: 32 (11) Pages: 2175-2182

    • Peer Reviewed
  • [Journal Article] Identification and characterization of acyl-protein thioesterase-1/lysophos pholipase-1 as a ghrelin deacylation enzyme in fetal bovine serum and conditioned medium.2010

    • Author(s)
      Satou M, Nishi Y, Yoh J, Sugimoto H et.al
    • Journal Title

      Endocrinology

      Volume: 151 (10); Pages: 4765-4775

    • Peer Reviewed
  • [Journal Article] Dihydrotestosterone suppresses foam cells formation and attenuates atherosclerosis development.2010

    • Author(s)
      Qiu Y, Yanase T, Hu H, Tanaka T, Nishi Yet al.
    • Journal Title

      Endocrinology

      Volume: 151 (7); Pages: 3307-3316

    • Peer Reviewed
  • [Journal Article] Dynamics of placental ghrelin production andits receptor expression in a Dahl salt-sensitive rat model of intrauterine growth restriction2010

    • Author(s)
      Nonoshita A, Nishi Y, Takushima S
    • Journal Title

      Placenta

      Volume: 31 (3); Pages: 358-364

    • Peer Reviewed
  • [Presentation] 肥満糖尿病モデルSDTfattyラットにおける過食とグレリン分泌動態2013

    • Author(s)
      田尻祐司,西芳寛,原健人,平田留美子,御船弘治
    • Organizer
      第27回日本糖尿病肥満動物学会
    • Place of Presentation
      東京
    • Year and Date
      20130222-0223
  • [Presentation] レット症候群モデルマウスにおけるグレリンの産生分泌動態とグレリンの治療応用2012

    • Author(s)
      西芳寛,平田留美子,御船弘治,細田洋司,寒川賢治,馬田敏幸,田中永一郎,児島将康,松石豊次郎
    • Organizer
      第39回日本神経内分泌学会学術集会
    • Place of Presentation
      北九州
    • Year and Date
      20120928-0929
  • [Presentation] 血中グレリン切断酵素の精製と分解産物の生理活性2012

    • Author(s)
      佐藤元康,杉本博之,西芳寛
    • Organizer
      第54回日本脂質生化学会
    • Place of Presentation
      福岡
    • Year and Date
      20120607-0608
  • [Presentation] Plasma ghrelin and serum IGF-1 levels in patients with Rett syndrome and its relationship to the head growth.2012

    • Author(s)
      Hara M, Nishi Y, Hirata R, Yoh J, Matsuishi T.
    • Organizer
      12th International Child Neurology Congress.
    • Place of Presentation
      Australia
    • Year and Date
      20120527-0601
  • [Presentation] グレリン補充に よるレット症候群への治療効果の検討、 厚生労働省障害者総合対策事業「レット症候群の早期診断と治療をめざした総合的研 究」・伊藤班2012

    • Author(s)
      松石豊次郎, 西芳寛
    • Organizer
      第2回班会議
    • Place of Presentation
      大阪
    • Year and Date
      2012-12-15
  • [Presentation] 自然発症高血圧ラットにおける血圧調節とグレリン産生分泌調節の相互作用の障害について2012

    • Author(s)
      濱田直和,西芳寛,田尻祐司,細田洋司,寒川賢治,児島将康,御船弘治
    • Organizer
      第12回日本内分泌学会九州地方会
    • Place of Presentation
      久留米
    • Year and Date
      2012-08-25
  • [Presentation] The role of ghrelin in patients with RTT and mecp2-null mouse model of RTT.、Rett Syndrome Symposium in Fukuoka2012

    • Author(s)
      Nishi Y
    • Organizer
      第115回 日本小児科学会学術総会サテライトシンポジウム(
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-22
  • [Presentation] レット症候群の低グレリン血症と臨床症状との関連2011

    • Author(s)
      原宗嗣,西芳寛,山下裕史朗,田中永一郎,児島将康,松石豊次郎
    • Organizer
      第111回九州医師会総会・医学会
    • Place of Presentation
      佐賀
    • Year and Date
      20111119-1120
  • [Presentation] 2型糖尿病モデルspontaneouslydiabeticTorii(SDT)ラットの食行動異常における活性型グレリン産生過剰の関与2011

    • Author(s)
      田尻祐司,御船弘治,西芳寛
    • Organizer
      第19回西日本肥満研究会
    • Place of Presentation
      福岡
    • Year and Date
      20110716-0717
  • [Presentation] Plasma concentrations of ghrelin in patients with Rett syndrome, together with their relationship to clinical manifestations.2011

    • Author(s)
      西 芳寛, 原 宗嗣, 葉 純子, 細田洋司,御船弘治 , 松石豊次郎 ほか
    • Organizer
      第84回 日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      20110421-0423
  • [Presentation] レット症候群の臨床的・基礎的研究、レット症候群シンポジウム2011:レット症候群の基礎・臨床研究から治療へ(2011

    • Author(s)
      西芳寛,原宗嗣,松石豊次郎
    • Organizer
      厚労省科学研究費難治性疾患克服研究事業
    • Place of Presentation
      大阪
    • Year and Date
      2011-12-04
  • [Presentation] Mecp2遺伝子変異をもつレット症候群患者の血漿中グレリン濃度の検討2011

    • Author(s)
      原宗嗣,葉純子,西芳寛,松石豊次郎ほか
    • Organizer
      第53回日本小児神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-05-20
  • [Presentation] Induction of early growth response ghne-1 expression by ligand activated ghrelin receptor with LY294002-dependent but PI3K/AKT -independent manner.2010

    • Author(s)
      Satou M, Sugimoto H, Nishi Y.
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20101207-1210
  • [Presentation] Plasma concentrations of ghrelin in patients with Rett syndrome and its relationship to the clinical manifestations.2010

    • Author(s)
      Hara M, Nishi Y, Yoh J et.al.
    • Organizer
      33rdAnnual Meeting of the Japan Neuroscience Society (Neuro2010) (
    • Place of Presentation
      神戸
    • Year and Date
      20100724-0725
  • [Presentation] レット症候群における血漿中グレリン濃度の検討2010

    • Author(s)
      原宗嗣,葉純子,西芳寛ほか
    • Organizer
      第52回日本小児神経学会総会
    • Place of Presentation
      福岡
    • Year and Date
      20100520-0522
  • [Presentation] 原 宗嗣、レット症候群の臨床研究と生物マーカーの確立、厚生労働省障害者総合対策事業「レット症候群の早期診断と治療をめざした統合的研究2010

    • Author(s)
      松石豊次郎, 角間辰之, 西 芳寛
    • Organizer
      」H24 年度第1回班会議
    • Place of Presentation
      福岡
    • Year and Date
      20100520-0521
  • [Remarks]

    • URL

      http://researchmap.jp/read0212158/http://research.kurume-u.ac.jp/http://profile.kurume-u.ac.jp/

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Published: 2014-08-29   Modified: 2015-01-06  

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