2012 Fiscal Year Final Research Report
Clinical and basic studies on the dynamics of ghrelin in Rett syndrome (RTT) together with a pilot-study on the clinical implication of ghrelin for the treatment of RTT-patients.
| Project/Area Number |
22591145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUISHI Toyojiro 久留米大学, 医学部, 教授 (60157237)
KAWAHARA Yukie 久留米大学, 医学部, 講師 (10279135)
MIFUNE Hiroharu 久留米大学, 医学部, 准教授 (70174117)
TANAKA Eiichiro 久留米大学, 医学部, 教授 (80188284)
YAMASHITA Yusihro 久留米大学, 医学部, 准教授 (90211630)
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Masayasu 久留米大学, 医学部, 教授 (20202062)
TAKAHASHI Tomoyuki 久留米大学, 医学部, 准教授 (20332687)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 発達小児科学 / Rett 症候群 / グレリン / 神経内分泌調節 |
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| Research Abstract |
In this study, we investigated the dynamics of ghrelin production in patients with Rett syndrome (RTT) together with that in mecp2-null mouse model of RTT (RTT-mouse). We also examined the effectiveness of “ghrelin-injection” on several clinical symptoms of RTT by using this RTT-mouse. Plasma levels of ghrelin were significantly lower in RTT patients with eating disorder or patients with insufficiency in gastro-intestinal movement. Deregulation of ghrelin production was also noted in the RTT-mouse. Daily injection of ghrelin into the RTT-mouse ameliorated the clinical symptom of them including “tremor”, “gait disturbance”, “hindlimb clasping” and “malnutrition” (body weight loss) from 6-9 weeks age. These findings of us support the future implication of “ghrelin-treatment” against several clinical symptoms typically seen in RTT patients.
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[Journal Article] Ghrelin levels are reduced in Rett syndrome with eating difficulties.2011
Author(s)
Hara M, Nishi Y, Yamashita Y, Yoh J, Takahashi S, Nagamitsu S, Kakuma T, Hosoda H, Kangawa K, Kojima M, Matsuishi T.
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Journal Title
International Journal of Develop-mental Neuroscience
Volume: 29
Pages: 899-902
Peer Reviewed
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