2012 Fiscal Year Final Research Report
The study for the development of neuroprotective therapy in acute and subacute encephalitis/encephalopathy.
| Project/Area Number |
22591147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
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Principal Investigator |
TANUMA Naoyuki 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 研究員 (00281676)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Masaharu 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 副参事研究員 (00280777)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳炎・脳症 / 酸化ストレス / タウ蛋白 / サイトカイン / 神経保護療法 / 抗神経抗体 / 自己免疫性脳炎 |
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| Research Abstract |
To develop neuroprotective therapy, we investigated the pathogeneisis of acute and subacute encephalitis/encephalopathy by measurements of cerebrospinal fluid (CSF) biomarkers in combination with conventional neuropathological analysis. The results suggest that CSF tau protein and 8-hydroxy-2’deoxyguanosine could be useful in following the clinical course and monitoring the efficacy of therapies. In addition, the use of patient serum for immunohistochemistry is a sensitive screening method for the detection of anti-neuronal autoantibodies in autoimmune encephalitis.
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[Journal Article] Oxidative stress markers and phosphorus magnetic resonance spectroscopy in a patient with GLUT1 deficiency treated with modified Atkins diet2012
Author(s)
Kitamura Y, Okumura A, Hayashi M, Mori H, Takahashi S, Yanagihara K, Miyata R, Tanuma N, Mimaki S, Abe S, Shimizu T
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Journal Title
Brain Dev
Volume: 34
Pages: 372-375
Peer Reviewed
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[Journal Article] Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS)2012
Author(s)
Miyata R, Tanuma N, Hayashi M, Imamura T, Takanashi J, Nagata R, Okumura A, Kashii H, Tomita S, Kumada S, Kubota M
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Journal Title
Brain Dev
Volume: 34
Pages: 124-127
Peer Reviewed
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