2012 Fiscal Year Final Research Report
Development of molecular targeted therapy of bone marrow fibrosis with BACH1 transgenic mice
| Project/Area Number |
22591149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Hirosaki University |
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Principal Investigator |
SASAKI Shinya 弘前大学, 医学部附属病院, 助教 (10344590)
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| Co-Investigator(Kenkyū-buntansha) |
TERUI Kiminori 弘前大学, 医学部附属病院, 講師 (00333740)
ITO Etsuro 弘前大学, 医学(系)研究科(研究院), 教授 (20168339)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 児血液学 / 骨髄線維症 / BACH1 |
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| Research Abstract |
We performed this study using BACH1 transgenic mice (model mice for myelofibrosis) to understand the mechanism of myelofibrosis and develop the molecular target therapy, and found the following results
We identified the thromboxane A synthase gene as a BACH1 target in megakaryocytes.
We investigated the anti-myelofibrosis effects of hepatocyte growth factor, which has a function of suppressing fibrosis of various tissues, on BACH1 transgenic mice. However, no significant effects were observed.
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Research Products
(16 results)
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[Journal Article] Frequent somatic mosaicism of NEMO in T cells of patients with X-1 linked anhidrotic ectodermal dysplasia with immunodeficiency2012
Author(s)
Kawai T, Nishikomori R, Izawa K, Murata Y, Tanaka N, Sakai H, Saito M, Yasumi T, Takaoka Y, Nakahata T, Mizukami T, Nunoi H, Kiyohara Y, Yoden A, Murata T, Sasaki S, Ito E, Akutagawa H, Kawai T, Imai C, Okada S, Kobayashi M, Heike T
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Journal Title
Blood
Volume: 119(23)
Pages: 5458-66
DOI
Peer Reviewed
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[Journal Article] Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia2010
Author(s)
Matsuda K, Sakashita K, Taira C, Tanaka-Yanagisawa M, Yanagisawa R, Shiohara M, Kanegane H, Hasegawa D, Kawasaki K, Endo M, Yajima S, Sasaki S, Kato K, Koike K, Kikuchi A, Ogawa A, Watanabe A, Sotomatsu M, Nonoyama S, Koike K.
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Journal Title
Br J Haematol
Volume: 148(4)
Pages: 593-9
DOI
Peer Reviewed
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